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Autotransplantations cellulaires en chirurgie orthopédique

Le but de notre projet est de développer des méthodes d'auto-transplantations cellulaires visant à favoriser la guérison des lésions musculaires fréquemment rencontrées dans la pratique orthopédique. Le principe consiste à utiliser les cellules qui contribuent à la reconstitution du tissu lésé (myoblastes) en partant des propres cellules du patient prélevées juste après l'accident. Ces cellules pourraient, de plus, être modifiées génétiquement afin de produire des facteurs favorisant leur prolifération et/ou leur résistance à l'inflammation.
Les hypothèses que nous voulons tester sont:
1. en augmentant le nombre de cellules réparatrices, on devrait favoriser une réparation plus rapide et de meilleure qualité des tissus lésés;
2. en modifiant génétiquement les cellules transplantées on devrait encore améliorer la régénération musculaire et diminuer la fibrose cicatricielle.

Pour réaliser les expériences permettant de tester ces hypothèses, il est nécessaire de mettre au point des méthodes de purification cellulaire puis de marquages cellulaires fiables afin de pouvoir suivre dans le tissu les cellules après transplantation. Il faut faire de même pour les méthodes permettant de modifier les cellules afin qu'elles sécrètent transitoirement des facteurs trophiques ou autres substances. Nous avons opté pour le développement d'un modèle animal proche de l'homme (le porc) afin de tester les hypothèses énoncées ci-dessus. ?

Spécifiquement:
(1) Rappelons que la dissociation d'une biopsie musculaire amène à une suspension cellulaire composée d'un mélange de myoblastes et de fibroblastes. La modification de notre protocole de dissociation a permis un gain de 9x dans le nombre de cellules satellites (CS) isolées (cellules précurseur des myoblastes) à partir d'un échantillon de muscle [669±84 CS/mg par rapport à 76±10 CS/mg].
(2)Une fois isolées, les cellules sont amplifiées en culture durant 1 semaine, ce qui permet l'obtention en moyenne de 10 millions de myoblastes pour 200'000 CS mise en culture. La caractérisation fonctionnelle (index de fusion) et immunohistologique (desmin, CD56) de ces cellules nous a permis de vérifier que plus de 80% des cellules transplantées sont des cellules myogènes, c'est-à-dire de la lignée des cellules capables de générer du muscle.
(3) L'étude de la transplantation de cellules satellites chez l'animal ne peut se faire sans un modèle standardisé. Nous avons développé un modèle de lacération par section directe et transverse du muscle tibialis anterior de la jambe du porc qui s'avère reproductible et fiable.
(4)De part la taille de l'animal, les spécimens histologiques à analyser sont très volumineux et ne peuvent être traités par les techniques histologiques standards. Nous avons développé un protocole d'enrobage en paraffine et de révélation de la galactosidase (LacZ) qui permet l'analyse de la survie et le suivi des cellules transplantées.

Pour suivre les myoblastes dans le muscle de porc après transplantation, il faut pouvoir disposer d'un marqueur qui résiste à la dilution par les divisions cellulaires et qui nous permette de reconnaître les cellules transplantées des cellules de l'hôte. Dans ce but, nous avons construit un rétrovirus capable de transférer dans les myoblastes le gène lacZ. Ce gène (qui ne sera présent que dans les cellules transplantées) permettra par simple coloration histologique de reconnaître les cellules transplantées. Cependant, la révélation du gène LacZ sur les volumineux spécimens du porc n'est pas toujours aisée. Nous avons donc construit un rétrovirus contenant le gène codant pour une GFP (protéine fluorescente) à localisation nucléaire et étudions lequel de ces marqueurs est le plus efficace pour évaluer la survie des cellules transplantées dans notre modèle expérimental.

Publications du groupe

Proximal row carpectomy in emergency.
CHIRURGIE DE LA MAIN
2010 vol. 29(4) pp. 224-230
DELLA SANTA D, SENNWALD G, MATHYS L, GLAUSER T, FUSETTI C, BEAULIEU JY

Cost-effectiveness of universal MRSA screening on admission to surgery.
CLINICAL MICROBIOLOGY AND INFECTION
2010 vol. 16(12) pp. 1747-1753
MURTHY A, DE ANGELIS G, PITTET D, SCHRENZEL J, UCKAY I, HARBARTH S

Early serum IGF-I response to oral protein supplements in elderly women with a recent hip fracture.
CLINICAL NUTRITION
2010 vol. 29(1) pp. 78-83
CHEVALLEY T, HOFFMEYER P, BONJOUR JP, RIZZOLI R

Risk factors for treatment failure in orthopedic device-related methicillin-resistant Staphylococcus aureus infection.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
2010 vol. 29(2) pp. 171-180
FERRY T, UCKAY I, VAUDAUX P, FRANCOIS P, SCHRENZEL J, HARBARTH S, LAURENT F, BERNARD L, VANDENESCH F, ETIENNE J, HOFFMEYER P, LEW D

An exercise intervention to improve diabetic patients' gait in a real-life environment.
GAIT & POSTURE
2010 vol. 32(2) pp. 185-190
ALLET L, ARMAND S, AMINIAN K, PATAKY Z, GOLAY A, DE BIE RA, DE BRUIN ED

Two consecutive deep sinus tract cultures predict the pathogen of osteomyelitis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
2010 vol. 14(5) pp. 390-393
BERNARD L, UCKAY I, VUAGNAT A, ASSAL M, STERN R, ROHNER P, HOFFMEYER P

Influence of obesity on femoral osteolysis five and ten years following total hip arthroplasty.
JOURNAL OF BONE AND JOINT SURGERY. AMERICAN VOLUME
2010 vol. 92(10) pp. 1964-1972
LUBBEKE A, GARAVAGLIA G, BAREA C, ROUSSOS C, STERN R, HOFFMEYER P

Realignment and extended fusion with use of a medial column screw for midfoot deformities secondary to diabetic neuropathy. Surgical technique.
JOURNAL OF BONE AND JOINT SURGERY. AMERICAN VOLUME
2010 vol. 92 pp. 20-31
ASSAL M, RAY A, STERN R

Late repair of abductor avulsion after the transgluteal approach for hip arthroplasty.
THE JOURNAL OF ARTHROPLASTY
2010 vol. 25(3) pp. 450-457
MIOZZARI HH, DORA C, CLARK JM, NÖTZLI HP

Six weeks of antibiotic treatment is sufficient following surgery for septic arthroplasty.
THE JOURNAL OF INFECTION
2010 vol. 61(2) pp. 125-132
BERNARD L, LEGOUT L, ZÜRCHER-PFUND L, STERN R, ROHNER P, PETER R, ASSAL M, LEW D, HOFFMEYER P, UCKAY I

Foreign body infections due to Staphylococcus epidermidis.
ANNALS OF MEDICINE
2009 vol. 41(2) pp. 109-119
UCKAY I, PITTET D, VAUDAUX P, SAX H, LEW D, WALDVOGEL FA

Biofeedback Training for Partial Weight Bearing in Patients After Total Hip Arthroplasty
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
2009 vol. 90(8) pp. 1435-1438
PATAKY Z, RODRIGUEZ DD, GOLAY A, ASSAL M, ASSAL JP, HAUERT C-A

Influence of preoperative patient education on the risk of dislocation after primary total hip arthroplasty.
ARTHRITIS AND RHEUMATISM --
2009 vol. 61(4) pp. 552-558
LUBBEKE A, SUVA D, PERNEGER T, HOFFMEYER P

Identification of Cancer Stem Cells in Ewing's Sarcoma
CANCER RESEARCH
2009 vol. 69(5) pp. 1776-1781
SUVA ML AND AL.

Investigation of standing balance in diabetic patients with and without peripheral neuropathy using accelerometers
CLINICAL BIOMECHANICS
2009 vol. 24(9) pp. 716-721
TURCOT K, ALLET L, GOLAY A, HOFFMEYER P, ARMAND S

Clinical factors associated with gait alterations in diabetic patients
DIABETIC MEDICINE
2009 vol. 26(10) pp. 1003-1009
ALLET L, ARMAND S, DE BIE RA, GOLAY A, PATAKY Z, AMINIAN K, DE BRUIN ED

Cockroaches (Ectobius vittiventris) in an intensive care unit, Switzerland.
EMERGING INFECTIOUS DISEASES (PRINT)
2009 vol. 15(3) pp. 496-497
UCKAY I, SAX H, LONGET-DI PIETRO S, BAUR H, BOULC'H MF, AKAKPO C, CHEVROLET JC, PITTET D

Clinical and radiological outcome of anterior-posterior fusion versus transforaminal lumbar interbody fusion for symptomatic disc degeneration: a retrospective comparative study of 133 patients
EUROPEAN SPINE JOURNAL
2009 vol. 18 pp. 203-211
FAUNDEZ AA, SCHWENDER JD, SAFRIEL Y, GILBERT TJ, MEHBOD AA, DENIS F, TRANSFELDT EE, WROBLEWSKI JM

Gait alterations of diabetic patients while walking on different surfaces
GAIT & POSTURE
2009 vol. 29(3) pp. 488-493
ALLET L, ARMAND S, DE BIE RA, PATAKY Z, AMINIAN K, HERRMANN FR, DE BRUIN ED

Use of serum antistreptolysin O titers in the microbial diagnosis of orthopedic infections.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
2009 vol. 13(4) pp. 421-424
UCKAY I, FERRY T, STERN R, AMBROSIONI J, GAMULIN A, ANDREY D, DJORDJEVIC M, BERNARD L, HOFFMEYER P, LEW D

MRI-based assessment of hip joint translations
JOURNAL OF BIOMECHANICS
2009 vol. 42(9) pp. 1201-1205
GILLES B, CHRISTOPHE FK, MAGNENAT-THALMANN N, BECKER CD, DUC SR, MENETREY J, HOFFMEYER P

Realignment and extended fusion with use of a medial column screw for midfoot deformities secondary to diabetic neuropathy.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
2009 vol. 91(4) pp. 812-820
ASSAL M, STERN R

Chronic diabetic ulcers under the first metatarsal head treated by staged tendon balancing: a prospective cohort study.
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
2009 vol. 91(4) pp. 487-493
DAYER R, ASSAL M

Partial atlE sequencing of Staphylococcus epidermidis strains from prosthetic joint infections.
JOURNAL OF CLINICAL MICROBIOLOGY
2009 vol. 47(7) pp. 2321-2324
SIVADON V AND AL.

Long-Term Outcomes of Closed Reduction and Percutaneous Pinning for the Treatment of Distal Radius Fractures
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
2009 vol. 34(5) pp. 963-963
VAN AAKEN J, BEAULIEU JY, FUSETTI C

Poor utility of MRSA screening to predict staphylococcal species in orthopaedic implant infections
JOURNAL OF HOSPITAL INFECTION
2009 vol. 73(1) pp. 89-91
UCKAY I, TETERYCZ D, FERRY T, HARBARTH S, LUBBEKE A, EMONET STEPHANE, CHILCOTT M, HOFFMEYER P, BERNARD L

Fatty infiltration of the supraspinatus: a reliability study.
JOURNAL OF SHOULDER AND ELBOW SURGERY / AMERICAN SHOULDER AND ELBOW SURGEONS ... [ET AL.]
2009 vol. 18(4) pp. 581-587
WILLIAMS MD, LADERMANN A, MELIS B, BARTHELEMY R, WALCH G

Objective evaluation of lengthening in reverse shoulder arthroplasty.
JOURNAL OF SHOULDER AND ELBOW SURGERY / AMERICAN SHOULDER AND ELBOW SURGEONS ... [ET AL.]
2009 vol. 18(4) pp. 588-595
LADERMANN A, WILLIAMS MD, MELIS B, HOFFMEYER P, WALCH G

Morbidity associated with isolated iliac wing fractures.
JOURNAL OF TRAUMA
2009 vol. 66(1) pp. 200-203
ABRASSART SOPHIE, STERN R, PETER R

BMI and severity of clinical and radiographic signs of hip osteoarthritis.
OBESITY (SILVER SPRING, MD.)
2009 vol. 17(7) pp. 1414-1419
LUBBEKE A, DUC S, GARAVAGLIA G, FINCKH A, HOFFMEYER P

Dyskinesia-induced postural instability in Parkinson's disease.
PARKINSONISM & RELATED DISORDERS
2009 vol. 15(5) pp. 359-364
ARMAND S, LANDIS T, SZTAJZEL R, BURKHARD PR

Assessment of patients' tendency to give a positive or negative rating to healthcare
QUALITY & SAFETY IN HEALTH CARE
2009 vol. 18(5) pp. 374-379
AGORITSAS T, LUBBEKE A, SCHIESARI L, PERNEGER T

Activity and impact on antibiotic use and costs of a dedicated infectious diseases consultant on a septic orthopaedic unit.
THE JOURNAL OF INFECTION
2009 vol. 58(3) pp. 205-212
UCKAY I, VERNAZ-HEGI N, HARBARTH S, STERN R, LEGOUT L, VAUTHEY L, FERRY T, LUBBEKE A, ASSAL M, LEW D, HOFFMEYER P, BERNARD L

Low incidence of haematogenous seeding to total hip and knee prostheses in patients with remote infections
THE JOURNAL OF INFECTION
2009 vol. 59(5) pp. 337-345
UCKAY I, LUBBEKE A, EMONET STEPHANE, TOVMIRZAEVA L, STERN R, FERRY T, ASSAL M, LEW D, HOFFMEYER P, BERNARD L, LEW D, HOFFMEYER P

Screw impingement on the extensor tendons in distal radius fractures treated by volar plating: sonographic appearance.
AMERICAN JOURNAL OF ROENTGENOLOGY
2008 vol. 191(5) pp. 199-203
BIANCHI S, VAN AAKEN J, GLAUSER T, MARTINOLI C, BEAULIEU JY, DELLA SANTA D

Sonography of masses of the wrist and hand.
AMERICAN JOURNAL OF ROENTGENOLOGY
2008 vol. 191(6) pp. 1767-1775
BIANCHI S, DELLA SANTA D, GLAUSER T, BEAULIEU JY, VAN AAKEN J

Acute, exertional medial compartment syndrome of the foot in a high-level athlete: a case report.
AMERICAN JOURNAL OF SPORTS MEDICINE
2008 vol. 36(5) pp. 983-986
MIOZZARI HH, GERARD R, STERN R, TOMAN JAROSLAVA, ASSAL M

Outcomes of obese and nonobese patients undergoing revision total hip arthroplasty.
ARTHRITIS AND RHEUMATISM --
2008 vol. 59(5) pp. 738-745
LUBBEKE A, MOONS KG, GARAVAGLIA G, HOFFMEYER P

Ventilator-associated pneumonia as a quality indicator for patient safety?
CLINICAL INFECTIOUS DISEASES
2008 vol. 46(4) pp. 557-563
UCKAY ILKER, AHMED QA, SAX H, PITTET D

Gait characteristics of diabetic patients: a systematic review.
DIABETES/METABOLISM RESEARCH AND REVIEWS
2008 vol. 24(3) pp. 173-191
ALLET L, ARMAND S, GOLAY A, MONNIN D, DE BIE RA, DE BRUIN ED

Reliability of diabetic patients' gait parameters in a challenging environment.
GAIT & POSTURE
2008 vol. 28(4) pp. 680-686
ALLET L, ARMAND S, DE BIE RA, GOLAY A, MONNIN D, AMINIAN K, DE BRUIN ED

Effect of screening for methicillin-resistant Staphylococcus aureus carriage by polymerase chain reaction on the duration of unnecessary preemptive contact isolation.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA
2008 vol. 29(11) pp. 1077-1079
UCKAY ILKER, SAX H, ITEN A, CAMUS V, RENZI G, SCHRENZEL J, PERRIER A, PITTET D

Antibiotic prophylaxis before invasive dental procedures in patients with arthroplasties of the hip and knee.
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
2008 vol. 90(7) pp. 833-838
UCKAY ILKER, PITTET D, BERNARD L, LEW D, PERRIER A, PETER R

In vitro activated human T lymphocytes very efficiently attach to allogenic multipotent mesenchymal stromal cells and transmigrate under them.
JOURNAL OF CELLULAR PHYSIOLOGY
2008 vol. 214(3) pp. 588-594
SUVA D, PASSWEG J., ARNAUDEAU S, HOFFMEYER P, KINDLER V

In vivo detection of clonally derived methicillin-resistant/methicillin-susceptible Staphylococcus aureus strains is not a rare event.
JOURNAL OF CLINICAL MICROBIOLOGY
2008 vol. 46(5) pp. 1890-1891
FRANCOIS P, UCKAY ILKER, ITEN A, RENZI G, DAHRAN S, CAMUS V, SAX H, SCHRENZEL J

Multi-resistant infections in repatriated patients after natural disasters: lessons learned from the 2004 tsunami for hospital infection control.
JOURNAL OF HOSPITAL INFECTION
2008 vol. 68(1) pp. 1-8
UCKAY ILKER, SAX H, HARBARTH S, BERNARD L, PITTET D

Biomechanical comparison of anterior lumbar interbody fusion and transforaminal lumbar interbody fusion.
JOURNAL OF SPINAL DISORDERS & TECHNIQUES
2008 vol. 21(2) pp. 120-125
PLOUMIS A, WU C, FISCHER G, MEHBOD AA, WU W, FAUNDEZ A, TRANSFELDT EE

Position of interbody spacer in transforaminal lumbar interbody fusion: effect on 3-dimensional stability and sagittal lumbar contour.
JOURNAL OF SPINAL DISORDERS & TECHNIQUES
2008 vol. 21(3) pp. 175-180
FAUNDEZ AA, MEHBOD AA, WU C, WU W, PLOUMIS A, TRANSFELDT EE

A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
2008 vol. 207(5) pp. 683-689
HARBARTH S, SAX H, UCKAY I, FANKHAUSER C, AGOSTINHO A, CHRISTENSON JT, RENZI G, SCHRENZEL J, PITTET D

Fixed-bearing versus mobile-bearing total knee arthroplasty: a prospective randomised, clinical and radiological study with mid-term results at 7 years.
KNEE
2008 vol. 15(3) pp. 206-210
LADERMANN A, LUBBEKE A, STERN R, RIAND N, FRITSCHY D

"Biological failure" of the anterior cruciate ligament graft.
KNEE SURGERY, SPORTS TRAUMATOLOGY, ARTHROSCOPY
2008 vol. 16(3) pp. 224-231
MENETREY J, DUTHON VB, LAUMONIER THOMAS, FRITSCHY D

Lentivirus mediated HO-1 gene transfer enhances myogenic precursor cell survival after autologous transplantation in pig.
MOLECULAR THERAPY
2008 vol. 16(2) pp. 404-410
LAUMONIER THOMAS, YANG SHENG, KONIG S, CHAUVEAU C, ANEGON I, HOFFMEYER P, MENETREY J

Delayed posttraumatic pseudoaneurysm of the anterior tibial artery mimicking a malignant tumor.
ORTHOPEDICS
2008 vol. 31(5) pp. 500-
LADERMANN A, STERN R, BETTSCHART V, RIAND N

The modified Lapidus procedure.
ORTHOPEDICS
2008 vol. 31(3) pp. 230-236
GERARD R, STERN R, ASSAL M

Unusual radiologic presentation of monostotic fibrous dysplasia.
ORTHOPEDICS
2008 vol. 31(3) pp. 282-
LADERMANN A, STERN R, CERONI D, DE COULON G, TAYLOR S, KAELIN A

Reversal of the hip fracture secular trend is related to a decrease in the incidence in institution-dwelling elderly women.
OSTEOPOROSIS INTERNATIONAL
2008 vol. 19(12) pp. 1741-1747
GUILLEY E, CHEVALLEY T, HERRMANN F, BACCINO D, HOFFMEYER P, RAPIN CH, RIZZOLI R

Vancomycin-induced DRESS syndrome in a female patient.
PHARMACOLOGY
2008 vol. 82(2) pp. 138-141
VAUTHEY L, UCKAY ILKER, ABRASSART SOPHIE, BERNARD L, ASSAL M, FERRY T, DJORDJEVIC M, ROUSSOS C, VAUDAUX P

Fixed-bearing versus mobile-bearing total knee arthroplasty: a prospective randomized clinical and radiological study
REVUE DE CHIRURGIE ORTHOPEDIQUE ET REPARATRICE DE L'APPAREIL MOTEUR
2008 vol. 94(3) pp. 247-251
LADERMANN A, SAUDAN M, RIAND N, FRITSCHY D

Articular nodular fasciitis in the glenohumeral joint.
SKELETAL RADIOLOGY
2008 vol. 37(7) pp. 663-666
LADERMANN A, KINDYNIS P, TAYLOR S, CERONI D, HOFFMEYER P, SORAVIA C, HERRMANN FR

Results of surgical repair of abductor avulsion after primary total hip arthroplasty.
THE JOURNAL OF ARTHROPLASTY
2008 vol. 23(5) pp. 694-698
LUBBEKE A, KAMPFEN S, STERN R, HOFFMEYER P

It's elemental
AMERICAN JOURNAL OF MEDICINE
2007 vol. 120 pp. 233-235
PETEK, D, BURKHARDT, K, LEGOUT, L

Accuracy of stress radiography techniques in grading isolated and combined posterior knee injuries
AMERICAN JOURNAL OF SPORTS MEDICINE
2007 vol. 35(12) pp. 2051-2056
GARAVAGLIA G, LUBBEKE A, DUBOIS-FERRIERE V, SUVA D, FRITSCHY D, MENETREY J

Differences in outcomes of obese women and men undergoing primary total hip arthroplasty
ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH
2007 vol. 57(2) pp. 327-334
LUBBEKE A, STERN R, GARAVAGLIA G, ZURCHER L, HOFFMEYER P

Incidence of hip fracture over a 10-year period (1991-2000): Reversal of a secular trend
BONE
2007 vol. 40 pp. 1284-1289
CHEVALLEY, T, GUILLEY, E, HERRMANN, FR, HOFFINEYER, P, RAPIN, CH, RIZZOLI, R

An unusual cause of hand cellulitis
CIRCULATION
2007 vol. 115 pp. 65-66
RIGHINI M, GUEDDI S, TAYLOR S, OTT V, DELLA SANTA D, BEAULIEU JY, BOUNAMEAUX H

Management of Gram-positive bacteraemia
CURRENT OPINION IN INFECTIOUS DISEASES
2007 vol. 20 pp. 561-567
UCKAY I, HARBARTH S, PITTET D

Streptococcus sinensis endocarditis outside Hong Kong
EMERGING INFECTIOUS DISEASES (PRINT)
2007 vol. 13(8) pp. 1250-1252
UCKAY I, ROHNER P, BOLIVAR I, NINET B, DJORDJEVIC M, NOBRE V, GARZONI C, SCHRENZEL J

Inactivation of a subpopulation of human neutrophils by exposure to ultrahigh-molecular-weight polyethylene wear debris
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
2007 vol. 49(3) pp. 425-432
BERNARD L., VAUDAUX P., HUGGLER E., FRÉHEL C., STERN R., FRANÇOIS P., LEW D., HOFFMEYER P.

Linking clinical measurements and kinematic gait patterns of toe-walking using fuzzy decision trees
GAIT & POSTURE
2007 vol. 25 pp. 475-484
ARMAND, S, WATELAIN, E, ROUX, E, MERCIER, M, LEPOUTRE, FX

Age limit does not replace serologic testing for determination of immune status for measles
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
2007 vol. 28 pp. 1117-1120
UCKAY I, HUGONNET S, KAISER L, SAX HG, PITTET D

Determinants of good adherence to hand hygiene among healthcare workers who have extensive exposure to hand hygiene campaigns
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA
2007 vol. 28(11) pp. 1267-1274
SAX H, UÇKAY I, RICHET H, ALLEGRANZI B, PITTET D

Are there advances in the treatment of extracapsular hip fractures in the elderly?
INJURY
2007 vol. 38 Suppl 3 pp. 77-87
STERN RICHARD

The risk of injury to neurovascular structures from distal locking screws of the Unreamed Humeral Nail (UHN): a cadaveric study
INJURY
2007 vol. 38(8) pp. 954-957
NOGER M, BERLI MC, FASEL JHD, HOFFMEYER PJ

Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement - A prospective randomised trial
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
2007 vol. 89 pp. 155-159
SAUDAN, M, SAUDAN, P, PERNEGER, T, RIAND, N, KELLER, A, HOFFMEYER, P

Defective implant osseointegration under protein undernutrition: Prevention by PTH or pamidronate
JOURNAL OF BONE AND MINERAL RESEARCH
2007 vol. 22 pp. 1526-1533
DAYER R, BADOUD I, RIZZOLI R, AMMANN P

Strontium ranelate treatment improves trabecular and cortical intrinsic bone tissue quality, a determinant of bone strength
JOURNAL OF BONE AND MINERAL RESEARCH
2007 vol. 22 pp. 1419-1425
AMMANN P, BADOUD I, BARRAUD S, DAYER R, RIZZOLI R

My five moments for hand hygiene': a user-centred design approach to understand, train, monitor and report hand hygiene
JOURNAL OF HOSPITAL INFECTION
2007 vol. 67 pp. 9-21
SAX H, ALLEGRANZI B, UCKAY I, LARSON E, BOYCE J, PITTET D

The extensile approach for the operative treatment of high-energy pilon fractures: Surgical technique and soft-tissue healing
JOURNAL OF ORTHOPAEDIC TRAUMA
2007 vol. 21 pp. 198-206
ASSAL, M, RAY, A, STERN, R

Tibial aplasia-hypoplasia and ectrodactyly in monozygotic twins with a discordant phenotype
JOURNAL OF PEDIATRIC ORTHOPAEDICS
2007 vol. 27 pp. 266-269
DAYER R, CERONI D, BOTTANI A, KAELIN A

Primary and revision hip arthroplasty: 5-year outcomes and influence of age and comorbidity
JOURNAL OF RHEUMATOLOGY.
2007 vol. 34(2) pp. 394-400
LÜBBEKE ANNE, KATZ JEFFREY N., PERNEGER THOMAS V., HOFFMEYER PIERRE

Definition, classification, rationale and treatment for PCl deficient knee
REVUE DE CHIRURGIE ORTHOPEDIQUE ET REPARATRICE DE L APPAREIL MOTEUR
2007 vol. 93 pp. 70-73
MENETREY J, GARAVAGLIA G, FRITSCHY D

Walking activity in prosthesis-bearing lower-limb amputees
REVUE DE CHIRURGIE ORTHOPEDIQUE ET REPARATRICE DE L APPAREIL MOTEUR
2007 vol. 93 pp. 109-115
CARMONA, GA, LACRAZ, A, ASSAL, M

Granulome éosinophile ischiatique et histiocytose pulmonaire d'évolution régressive
REVUE DE CHIRURGIE ORTHOPEDIQUE ET REPARATRICE DE L'APPAREIL MOTEUR
2007 vol. 93(5) pp. 505-505
GERARD R., KELLER A., TAYLOR S., HOFFMEYER P., PETER R.

Heat shock pretreatment enhances porcine myoblasts survival after autotransplantation in intact skeletal muscle
SCIENCE IN CHINA SERIES C-LIFE SCIENCES
2007 vol. 50 pp. 438-446
YANG, S, LAUMONIER, T, MENETREY, J

Myogenic precursor cell transplantation in pigs: a step towards a clinical use for muscle regeneration?
SWISS MEDICAL WEEKLY
2007 vol. 137 Suppl 155 pp. 44-48
LAUMONIER THOMAS, HOLZER NICOLAS, BERNHEIM LAURENT, HOFFMEYER PIERRE, BADER CHARLES R., MENETREY JACQUES

Partial sensory and motor deficit of ipsilateral lower limb after continuous interscalene brachial plexus block
ANESTHESIA AND ANALGESIA
2006 vol. 102(1) pp. 288-290
FAUST A, FOURNIER R, HAGON O, HOFFMEYER P, GAMULIN Z

The new IL-1 family member IL-1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes
ARTHRITIS RESEARCH & THERAPY
2006 vol. 8 pp. 0-0
MAGNE D, PALMER G, BARTON JL, MEZIN F, TALABOT-AYER D, BAS S, DUFFY T, NOGER M, GUERNE PA, NICKLIN MJH, GABAY C

Reduction of urinary tract infection and antibiotic use after surgery: A controlled, prospective, befor after intervention study
CLINICAL INFECTIOUS DISEASES
2006 vol. 42 pp. 1544-1551
STEPHAN F, SAX H, WACHSMUTH M, HOFFMEYER P, CLERGUE F, PITTET D

Treatment of bone and joint infections caused by Gram-negative bacilli with a cefepime-fluoroquinolone combination
CLINICAL MICROBIOLOGY AND INFECTION
2006 vol. 12 pp. 1030-1033
LEGOUT L, SENNEVILLE E, STERN R, YAZDANPANAH Y, SAVAGE C, ROUSSEL-DELVALEZ M, ROSELE B, MIGAUD H, MOUTON Y

Instrumented fusion of thoracolumbar fracture with type I mineralized collagen matrix combined with autogenous bone marrow as a bone graft substitute: a four-case report
EUROPEAN SPINE JOURNAL
2006 vol. 15(Supplement 17) pp. 630-635
FAUNDEZ AA, TAYLOR S, KAELIN A

Hip pain from impingement and dysplasia in patients aged 20-50 years. Workup and role for reconstruction
JOINT BONE SPINE
2006 vol. 73(6) pp. 614-623
LANGLAIS FRANTZ ET AL.

Recurrent osteomyelitis caused by infection with different bacterial strains without obvious source of reinfection
JOURNAL OF CLINICAL MICROBIOLOGY
2006 vol. 44(3) pp. 1194-1196
UÇKAY ILKER, ASSAL MATHIEU, LEGOUT LAURENCE, ROHNER PETER, STERN RICHARD, LEW DANIEL, HOFFMEYER PIERRE, BERNARD LOUIS

Arterial supply of the glenoid: an anatomic study
JOURNAL OF SHOULDER AND ELBOW SURGERY / AMERICAN SHOULDER AND ELBOW SURGEONS ... [ET AL.]
2006 vol. 15(2) pp. 232-238
ABRASSART SOPHIE, STERN RICHARD, HOFFMEYER PIERRE

Successful treatment of Candida parapsilosis (fluconazole-resistant) osteomyelitis with caspofungin in a HIV patient
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
2006 vol. 38 pp. 728-730
LEGOUT L, ASSAL M, ROHNER P, LEW D, BERNARD L, HOFFMEYER P

Suction drainage culture as a guide to effectively treat musculoskeletal infection
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
2006 vol. 38 pp. 341-345
LEGOUT L, STERN R, ASSAL M, ROHNER P, MERLE C, HOFFMEYER P, BERNARD L

"Re: Ames CP, Acosta FL Jr, Chi J, et al. Biomechanical comparison of posterior lumbar interbody fusion and transforaminal lumbar interbody fusion performed at 1 and 2 levels. Spine 2005; 30 : E562 -6."
SPINE
2006 vol. 31 pp. 504-504
FAUNDEZ AA

Haematopoietic stem cells and mesenchymal stem cells as tools for present and future cellular therapies
SWISS MEDICAL WEEKLY
2006 vol. 136 pp. 333-337
KINDLER V, SUVA D, SOULAS C, CHAPUIS B

Diagnosis of occult scaphoid fracture with high-spatial-resolution sonography : a prospective blind study
JOURNAL OF TRAUMA
2005 vol. 59 pp. 677-681
FUSETTI CESARE, POLETTI PIERRE-ALEXANDRE, PRADEL PHILIPPE, GARAVAGLIA GUIDO, PLATON ALEXANDRA, DELLA SANTA DOMINIQUE, BIANCHI STEFANO

Autologous transplantation of porcine myogenic precursor cells in skeletal muscle
NEUROMUSCULAR DISORDERS
2005 vol. 15(3)1 pp. 237-244
HOLZER NICOLAS, HOOGENDORN SIMONE, ZURCHER LINE, YANG SHENG, KONIG STEPHANE, LAUMONIER THOMAS, MENETREY JACQUES

Möglichkeiten der computergestutzten Navigation bei kniegelenknahen Osteotomien
DER ORTHOPADE
2004 vol. 33 pp. 224-228
MENETREY JACQUES, PAUL MATTHIAS

Domaines de recherche




BASE DE DONNÉES-RECHERCHE	GROUPE DE RECHERCHE CLINIQUE ORIENTEE PATIENTS

J MENETREY et P HOFFMEYER	CV du Chef de Groupe	Sujet de Recherche	Composition du Groupe