Welcome in the research database

Chronic kidney disease.

Chronic kidney disease (CKD) is a frequent and currently non reversible disease. It has become a major health problem. Progression of CKD is correlated better to tubulointerstitial than glomerular lesions. Progression of CKD is due to interstitial fibrosis and inflammation progression in the kidney. Dr Sophie de seigneux's SNF project aims at understanding the role of tubular cells in kidney disease progression to define new therapeutic targets in order to slow the disease. Tubular cells indeed produce ROS, inflammatory factors and may be one of the main actor in kidney hypoxia given their high metabolic activity. NADPH oxidase 4 is specifically studied, as well as the role of proteinuria on tubular cells and CKD progression.

Group's publications

Acute Interstitial Nephritis After Treatment With Liraglutide.
AMERICAN JOURNAL OF KIDNEY DISEASES : THE OFFICIAL JOURNAL OF THE NATIONAL KIDNEY FOUNDATION
2013 vol. 6386(13) pp. 1459-
GARIANI K, DE SEIGNEUX S, MOLL S

Albuminuria induces a proinflammatory and profibrotic response in cortical collecting ducts via the 24p3 receptor.
AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY
2013 vol. 305(7) pp. 1053-1063
DIZIN E, HASLER U, NLANDU KHODO S, FILA M, ROTH I, ERNANDEZ T, DOUCET A, MARTIN PY, FERAILLE E, DE SEIGNEUX S

N-acetylcysteine does not prevent contrast nephropathy in patients with renal impairment undergoing emergency CT: a randomized study.
BMC NEPHROLOGY [COMPUTER FILE]
2013 vol. 14(1) pp. 119-119
POLETTI PA, PLATON A, DE SEIGNEUX S, DUPUIS LOZERON E, SARASIN FP, BECKER CD, PERNEGER T, SAUDAN P, MARTIN PY

Sodium Transport Is Modulated by p38 Kinase-Dependent Cross-Talk between ENaC and Na,K-ATPase in Collecting Duct Principal Cells.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2013 vol. pp. 0-
WANG Y, LEROY V, MAUNSBACH AB, DOUCET A, HASLER U, DIZIN E, ERNANDEZ T, DE SEIGNEUX S, MARTIN PY, FERAILLE E

Carbimazole-induced, ANCA-associated, crescentic glomerulonephritis: case report and literature review.
RENAL FAILURE
2013 vol. 35(3) pp. 414-417
MAVRAKANAS T, BOUATOU Y, SAMER CF, DE SEIGNEUX S, MEYER P

Determination of the best method to estimate glomerular filtration rate from serum creatinine in adult patients with sickle cell disease: a prospective observational cohort study.
BMC NEPHROLOGY [COMPUTER FILE]
2012 vol. 13 pp. 83-83
ARLET JB, RIBEIL JA, CHATELLIER G, ELADARI D, DE SEIGNEUX S, SOUBERBIELLE JC, FRIEDLANDER G, DE MONTALEMBERT M, POUCHOT J, PRIÉ D, COURBEBAISSE M

Epoetin administrated after cardiac surgery: effects on renal function and inflammation in a randomized controlled study.
BMC NEPHROLOGY [COMPUTER FILE]
2012 vol. 13 pp. 132-132
DE SEIGNEUX S, PONTE B, WEISS L, PUGIN J, ROMAND J, MARTIN PY, SAUDAN P

Oxalate nephropathy induced by octreotide treatment for acromegaly: a case report.
JOURNAL OF MEDICAL CASE REPORTS
2012 vol. 6(1) pp. 615-615
GARIANI K, DE SEIGNEUX S, COURBEBAISSE M, LEVY M, MOLL S, MARTIN PY

NADPH-oxidase 4 protects against kidney fibrosis during chronic renal injury.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2012 vol. 23(12) pp. 1967-1976
NLANDU KHODO S, DIZIN E, SOSSAUER G, SZANTO I, MARTIN PY, FERAILLE E, KRAUSE KH, DE SEIGNEUX S

Evidence of follicular T-cell implication in a case of IgG4-related systemic disease with interstitial nephritis.
NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION
2011 vol. 26(6) pp. 2047-2050
ZAIDAN M, CERVERA-PIEROT P, DE SEIGNEUX S, DAHAN K, FABIANI B, CALLARD P, RONCO P, AUCOUTURIER P

Rituximab treatment for membranous nephropathy: a French clinical and serological retrospective study of 28 patients.
NEPHRON EXTRA
2011 vol. 1(1) pp. 251-261
MICHEL PA AND AL.

Immunoglobulin deposition disease with a membranous pattern and a circulating monoclonal immunoglobulin G with charge-dependent aggregation properties.
AMERICAN JOURNAL OF KIDNEY DISEASES : THE OFFICIAL JOURNAL OF THE NATIONAL KIDNEY FOUNDATION
2010 vol. 56(1) pp. 117-121
DE SEIGNEUX S, BINDI P, DEBIEC H, ALYANAKIAN M, AYMARD B, CALLARD P, RONCO P, AUCOUTURIER P

Aldosterone Activates NF-kappa B in the Collecting Duct
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2009 vol. 20(1) pp. 131-144
LEROY V, DE SEIGNEUX S, AGASSIZ V, HASLER U, RAFESTIN-OBLIN ME, VINCIGUERRA M, MARTIN PY, FERAILLE E

Rapid and segmental specific dysregulation of AQP2, S256-pAQP2 and renal sodium transporters in rats with LPS-induced endotoxaemia.
NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION
2009 vol. 24(8) pp. 2338-2349
OLESEN ET, DE SEIGNEUX S, WANG G, LÜTKEN SC, FRØKIAER J, KWON TH, NIELSEN S

Management of patients with nephrotic syndrome.
SWISS MEDICAL WEEKLY
2009 vol. 139(29-30) pp. 416-422
DE SEIGNEUX S, MARTIN PY

NF-kappaB inhibits sodium transport via down-regulation of SGK1 in renal collecting duct principal cells.
JOURNAL OF BIOLOGICAL CHEMISTRY
2008 vol. 283(37) pp. 25671-25681
DE SEIGNEUX S, LEROY V, GHZILI H, ROUSSELOT M, NIELSEN S, ROSSIER BC, MARTIN PY, FERAILLE E

Calcium-sensing receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2008 vol. 19(1) pp. 109-116
BUSTAMANTE M, HASLER U, LEROY V, DE SEIGNEUX S, DIMITROV M, MORDASINI D, ROUSSELOT M, MARTIN PY, FERAILLE E

Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney.
AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY
2007 vol. 293(1) pp. 87-99
DE SEIGNEUX S, NIELSEN J, OLESEN ET, DIMKE H, KWON TH, FRØKIAER J, NIELSEN

Renal compensation to chronic hypoxic hypercapnia: downregulation of pendrin and adaptation of the proximal tubule.
AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY
2007 vol. 292(4) pp. 1256-1266
DE SEIGNEUX S, MALTE H, DIMKE H, FRØKIAER J, NIELSEN S, FRISCHE S

Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats.
AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY
2006 vol. 290(3) pp. 674-687
KIM SW, DE SEIGNEUX S, SASSEN MC, LEE J, KIM J, KNEPPER MA, FRØKIAER J, NIELSEN S

Increased expression but not targeting of ENaC in adrenalectomized rats with PAN-induced nephrotic syndrome.
AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY
2006 vol. 291(1) pp. 208-217
DE SEIGNEUX S, KIM SW, HEMMINGSEN SC, FRØKIAER J, NIELSEN S

Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure
KIDNEY INTERNATIONAL
2006 vol. 70(7) pp. 1312-1317
SAUDAN P, NIEDERBERGER M, DE SEIGNEUX S, ROMAND J, PUGIN J, PERNEGER T, MARTIN PY

Research's domains

OXYDATIVE STRESS
PROTEINURIA
KIDNEY FIBROSIS
CHRONIC KIDNEY DISEASE
TUBULAR CELLS




DATABASE-RESEARCH	GROUP OF CLINICAL BIOLOGY RESEARCH

Dr Sophie de Seigneux	Head of group CV	Research subject	Members of the group


	Links about the group Dr Sophie de Seigneux HUG/Spécialités de médecine Service de néphrologie Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Sophie.deSeigneux@hcuge.ch Tel.: +41 79 55 33 220 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Chronic kidney disease. Chronic kidney disease (CKD) is a frequent and currently non reversible disease. It has become a major health problem. Progression of CKD is correlated better to tubulointerstitial than glomerular lesions. Progression of CKD is due to interstitial fibrosis and inflammation progression in the kidney. Dr Sophie de seigneux's SNF project aims at understanding the role of tubular cells in kidney disease progression to define new therapeutic targets in order to slow the disease. Tubular cells indeed produce ROS, inflammatory factors and may be one of the main actor in kidney hypoxia given their high metabolic activity. NADPH oxidase 4 is specifically studied, as well as the role of proteinuria on tubular cells and CKD progression. Group's publications Acute Interstitial Nephritis After Treatment With Liraglutide. AMERICAN JOURNAL OF KIDNEY DISEASES : THE OFFICIAL JOURNAL OF THE NATIONAL KIDNEY FOUNDATION 2013 vol. 6386(13) pp. 1459- GARIANI K, DE SEIGNEUX S, MOLL S Albuminuria induces a proinflammatory and profibrotic response in cortical collecting ducts via the 24p3 receptor. AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY 2013 vol. 305(7) pp. 1053-1063 DIZIN E, HASLER U, NLANDU KHODO S, FILA M, ROTH I, ERNANDEZ T, DOUCET A, MARTIN PY, FERAILLE E, DE SEIGNEUX S N-acetylcysteine does not prevent contrast nephropathy in patients with renal impairment undergoing emergency CT: a randomized study. BMC NEPHROLOGY [COMPUTER FILE] 2013 vol. 14(1) pp. 119-119 POLETTI PA, PLATON A, DE SEIGNEUX S, DUPUIS LOZERON E, SARASIN FP, BECKER CD, PERNEGER T, SAUDAN P, MARTIN PY Sodium Transport Is Modulated by p38 Kinase-Dependent Cross-Talk between ENaC and Na,K-ATPase in Collecting Duct Principal Cells. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2013 vol. pp. 0- WANG Y, LEROY V, MAUNSBACH AB, DOUCET A, HASLER U, DIZIN E, ERNANDEZ T, DE SEIGNEUX S, MARTIN PY, FERAILLE E Carbimazole-induced, ANCA-associated, crescentic glomerulonephritis: case report and literature review. RENAL FAILURE 2013 vol. 35(3) pp. 414-417 MAVRAKANAS T, BOUATOU Y, SAMER CF, DE SEIGNEUX S, MEYER P Determination of the best method to estimate glomerular filtration rate from serum creatinine in adult patients with sickle cell disease: a prospective observational cohort study. BMC NEPHROLOGY [COMPUTER FILE] 2012 vol. 13 pp. 83-83 ARLET JB, RIBEIL JA, CHATELLIER G, ELADARI D, DE SEIGNEUX S, SOUBERBIELLE JC, FRIEDLANDER G, DE MONTALEMBERT M, POUCHOT J, PRIÉ D, COURBEBAISSE M Epoetin administrated after cardiac surgery: effects on renal function and inflammation in a randomized controlled study. BMC NEPHROLOGY [COMPUTER FILE] 2012 vol. 13 pp. 132-132 DE SEIGNEUX S, PONTE B, WEISS L, PUGIN J, ROMAND J, MARTIN PY, SAUDAN P Oxalate nephropathy induced by octreotide treatment for acromegaly: a case report. JOURNAL OF MEDICAL CASE REPORTS 2012 vol. 6(1) pp. 615-615 GARIANI K, DE SEIGNEUX S, COURBEBAISSE M, LEVY M, MOLL S, MARTIN PY NADPH-oxidase 4 protects against kidney fibrosis during chronic renal injury. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2012 vol. 23(12) pp. 1967-1976 NLANDU KHODO S, DIZIN E, SOSSAUER G, SZANTO I, MARTIN PY, FERAILLE E, KRAUSE KH, DE SEIGNEUX S Evidence of follicular T-cell implication in a case of IgG4-related systemic disease with interstitial nephritis. NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION 2011 vol. 26(6) pp. 2047-2050 ZAIDAN M, CERVERA-PIEROT P, DE SEIGNEUX S, DAHAN K, FABIANI B, CALLARD P, RONCO P, AUCOUTURIER P Rituximab treatment for membranous nephropathy: a French clinical and serological retrospective study of 28 patients. NEPHRON EXTRA 2011 vol. 1(1) pp. 251-261 MICHEL PA AND AL. Immunoglobulin deposition disease with a membranous pattern and a circulating monoclonal immunoglobulin G with charge-dependent aggregation properties. AMERICAN JOURNAL OF KIDNEY DISEASES : THE OFFICIAL JOURNAL OF THE NATIONAL KIDNEY FOUNDATION 2010 vol. 56(1) pp. 117-121 DE SEIGNEUX S, BINDI P, DEBIEC H, ALYANAKIAN M, AYMARD B, CALLARD P, RONCO P, AUCOUTURIER P Aldosterone Activates NF-kappa B in the Collecting Duct JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2009 vol. 20(1) pp. 131-144 LEROY V, DE SEIGNEUX S, AGASSIZ V, HASLER U, RAFESTIN-OBLIN ME, VINCIGUERRA M, MARTIN PY, FERAILLE E Rapid and segmental specific dysregulation of AQP2, S256-pAQP2 and renal sodium transporters in rats with LPS-induced endotoxaemia. NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION 2009 vol. 24(8) pp. 2338-2349 OLESEN ET, DE SEIGNEUX S, WANG G, LÜTKEN SC, FRØKIAER J, KWON TH, NIELSEN S Management of patients with nephrotic syndrome. SWISS MEDICAL WEEKLY 2009 vol. 139(29-30) pp. 416-422 DE SEIGNEUX S, MARTIN PY NF-kappaB inhibits sodium transport via down-regulation of SGK1 in renal collecting duct principal cells. JOURNAL OF BIOLOGICAL CHEMISTRY 2008 vol. 283(37) pp. 25671-25681 DE SEIGNEUX S, LEROY V, GHZILI H, ROUSSELOT M, NIELSEN S, ROSSIER BC, MARTIN PY, FERAILLE E Calcium-sensing receptor attenuates AVP-induced aquaporin-2 expression via a calmodulin-dependent mechanism. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 2008 vol. 19(1) pp. 109-116 BUSTAMANTE M, HASLER U, LEROY V, DE SEIGNEUX S, DIMITROV M, MORDASINI D, ROUSSELOT M, MARTIN PY, FERAILLE E Long-term aldosterone treatment induces decreased apical but increased basolateral expression of AQP2 in CCD of rat kidney. AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY 2007 vol. 293(1) pp. 87-99 DE SEIGNEUX S, NIELSEN J, OLESEN ET, DIMKE H, KWON TH, FRØKIAER J, NIELSEN Renal compensation to chronic hypoxic hypercapnia: downregulation of pendrin and adaptation of the proximal tubule. AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY 2007 vol. 292(4) pp. 1256-1266 DE SEIGNEUX S, MALTE H, DIMKE H, FRØKIAER J, NIELSEN S, FRISCHE S Increased apical targeting of renal ENaC subunits and decreased expression of 11betaHSD2 in HgCl2-induced nephrotic syndrome in rats. AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY 2006 vol. 290(3) pp. 674-687 KIM SW, DE SEIGNEUX S, SASSEN MC, LEE J, KIM J, KNEPPER MA, FRØKIAER J, NIELSEN S Increased expression but not targeting of ENaC in adrenalectomized rats with PAN-induced nephrotic syndrome. AMERICAN JOURNAL OF PHYSIOLOGY. RENAL PHYSIOLOGY 2006 vol. 291(1) pp. 208-217 DE SEIGNEUX S, KIM SW, HEMMINGSEN SC, FRØKIAER J, NIELSEN S Adding a dialysis dose to continuous hemofiltration increases survival in patients with acute renal failure KIDNEY INTERNATIONAL 2006 vol. 70(7) pp. 1312-1317 SAUDAN P, NIEDERBERGER M, DE SEIGNEUX S, ROMAND J, PUGIN J, PERNEGER T, MARTIN PY Research's domains OXYDATIVE STRESS PROTEINURIA KIDNEY FIBROSIS CHRONIC KIDNEY DISEASE TUBULAR CELLS