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Imaging-assisted neurorehabilitation.

Neurological and cognitive deficits are frequent and highly disabling. Intensive training and rehabilitation can lead to improvement, but the selection of efficient treatment strategies for the individual patient is often difficult because of insufficient knowledge about how the human brain can recover lost functions. We make use of recent advances in neuroimaging techniques to non-invasively assess brain organization and to support the rehabilitation of patients with brain lesions.

In particular, we aim to:

1) characterize the changes in brain organization induced by focal lesions or diffuse degeneration;
2) visualize the mechanisms underlying functional recovery;
3) identify prognostic factors;
4) assess the effect of novel treatment approaches that might improve recovery, such as transcranial stimulation, neuro-feedback, and others.

Group's publications

Variability of behavioural responses to transcranial magnetic stimulation: Origins and predictors.
NEUROPSYCHOLOGIA
2015 vol. pp. 40-48
NICOLO P, PTAK R, GUGGISBERG A

Neurofeedback training of alpha-band coherence enhances motor performance.
CLINICAL NEUROPHYSIOLOGY
2014 vol. pp. 0-
MOTTAZ A, SOLCA M, MAGNIN C, CORBET T, SCHNIDER A, GUGGISBERG A

Adaptive reorganization of cortical networks in Alzheimer's disease.
CLINICAL NEUROPHYSIOLOGY
2013 vol. 124(1) pp. 35-43
DUBOVIK S, WAHLEN A, NAHUM L, GOLD G, SCHNIDER A, GUGGISBERG A

Network mechanisms of responsiveness to continuous theta-burst stimulation.
EUROPEAN JOURNAL OF NEUROSCIENCE
2013 vol. 38(8) pp. 3230-3238
RIZK S, PTAK R, NYFFELER T, SCHNIDER A, GUGGISBERG A

Resting state ż-band functional connectivity and recovery after stroke.
EXPERIMENTAL NEUROLOGY
2012 vol. 237(1) pp. 160-169
WESTLAKE KP, HINKLEY LB, BUCCI M, GUGGISBERG A, BYL N, FINDLAY AM, HENRY RG, NAGARAJAN SS

The behavioral significance of coherent resting-state oscillations after stroke.
NEUROIMAGE
2012 vol. 61(1) pp. 249-257
DUBOVIK S AND AL.

Resting functional connectivity in patients with brain tumors in eloquent areas.
ANNALS OF NEUROLOGY
2011 vol. 69(3) pp. 521-532
MARTINO J, HONMA SM, FINDLAY AM, GUGGISBERG A, KIRSCH HE, BERGER MS, NAGARAJAN SS

MEG/EEG source reconstruction, statistical evaluation, and visualization with NUTMEG.
COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE
2011 vol. 2011 pp. 758973-758973
DALAL SS, ZUMER JM, GUGGISBERG A, TRUMPIS M, WONG DD, SEKIHARA K, NAGARAJAN SS

The neural basis of event-time introspection.
CONSCIOUSNESS AND COGNITION
2011 vol. 20(4) pp. 1899-1915
GUGGISBERG A, DALAL SS, SCHNIDER A, NAGARAJAN SS

Localization of cortico-peripheral coherence with electroencephalography.
NEUROIMAGE
2011 vol. 57(4) pp. 1348-1357
GUGGISBERG A, DALAL SS, ZUMER JM, WONG DD, DUBOVIK S, MICHEL CM, SCHNIDER A

Mapping functional connectivity in patients with brain lesions.
ANNALS OF NEUROLOGY
2008 vol. 63(2) pp. 193-203
GUGGISBERG A, HONMA SM, FINDLAY AM, DALAL SS, KIRSCH HE, BERGER MS, NAGARAJAN SS

Fast oscillations associated with interictal spikes localize the epileptogenic zone in patients with partial epilepsy.
NEUROIMAGE
2008 vol. 39(2) pp. 661-668
GUGGISBERG A, KIRSCH HE, MANTLE MM, BARBARO NM, NAGARAJAN SS

Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity.
NEUROIMAGE
2008 vol. 40(4) pp. 1686-1700
DALAL SS AND AL.

The functional relationship between yawning and vigilance.
BEHAVIOURAL BRAIN RESEARCH
2007 vol. 179(1) pp. 159-166
GUGGISBERG A, MATHIS J, HERRMANN US, HESS CW

The significance of the sympathetic nervous system in the pathophysiology of periodic leg movements in sleep.
SLEEP
2007 vol. 30(6) pp. 755-766
GUGGISBERG A, HESS CW, MATHIS J

Research's domains

NEURO IMAGING




DATABASE-RESEARCH	GROUP OF CLINICAL PATIENT RESEARCH

Guggisberg Adrian	Head of group CV	Research subject	Members of the group


	Links about the group Guggisberg A. Beau-Séjour /Dpt NEUCLID Serv. de Neurorééducation Avenue de Beau-Séjour 26 1211 Genève 14 Suisse Adrian.Guggisberg@hcuge.ch Tel.: +41 22 382 3521 Fax: +41 22 382 3644 Comments Pages updated the 17.11.2015		Reseach's subject \| Group's publications \| Research's domains Imaging-assisted neurorehabilitation. Neurological and cognitive deficits are frequent and highly disabling. Intensive training and rehabilitation can lead to improvement, but the selection of efficient treatment strategies for the individual patient is often difficult because of insufficient knowledge about how the human brain can recover lost functions. We make use of recent advances in neuroimaging techniques to non-invasively assess brain organization and to support the rehabilitation of patients with brain lesions. In particular, we aim to: 1) characterize the changes in brain organization induced by focal lesions or diffuse degeneration; 2) visualize the mechanisms underlying functional recovery; 3) identify prognostic factors; 4) assess the effect of novel treatment approaches that might improve recovery, such as transcranial stimulation, neuro-feedback, and others. Group's publications Variability of behavioural responses to transcranial magnetic stimulation: Origins and predictors. NEUROPSYCHOLOGIA 2015 vol. pp. 40-48 NICOLO P, PTAK R, GUGGISBERG A Neurofeedback training of alpha-band coherence enhances motor performance. CLINICAL NEUROPHYSIOLOGY 2014 vol. pp. 0- MOTTAZ A, SOLCA M, MAGNIN C, CORBET T, SCHNIDER A, GUGGISBERG A Adaptive reorganization of cortical networks in Alzheimer's disease. CLINICAL NEUROPHYSIOLOGY 2013 vol. 124(1) pp. 35-43 DUBOVIK S, WAHLEN A, NAHUM L, GOLD G, SCHNIDER A, GUGGISBERG A Network mechanisms of responsiveness to continuous theta-burst stimulation. EUROPEAN JOURNAL OF NEUROSCIENCE 2013 vol. 38(8) pp. 3230-3238 RIZK S, PTAK R, NYFFELER T, SCHNIDER A, GUGGISBERG A Resting state ż-band functional connectivity and recovery after stroke. EXPERIMENTAL NEUROLOGY 2012 vol. 237(1) pp. 160-169 WESTLAKE KP, HINKLEY LB, BUCCI M, GUGGISBERG A, BYL N, FINDLAY AM, HENRY RG, NAGARAJAN SS The behavioral significance of coherent resting-state oscillations after stroke. NEUROIMAGE 2012 vol. 61(1) pp. 249-257 DUBOVIK S AND AL. Resting functional connectivity in patients with brain tumors in eloquent areas. ANNALS OF NEUROLOGY 2011 vol. 69(3) pp. 521-532 MARTINO J, HONMA SM, FINDLAY AM, GUGGISBERG A, KIRSCH HE, BERGER MS, NAGARAJAN SS MEG/EEG source reconstruction, statistical evaluation, and visualization with NUTMEG. COMPUTATIONAL INTELLIGENCE AND NEUROSCIENCE 2011 vol. 2011 pp. 758973-758973 DALAL SS, ZUMER JM, GUGGISBERG A, TRUMPIS M, WONG DD, SEKIHARA K, NAGARAJAN SS The neural basis of event-time introspection. CONSCIOUSNESS AND COGNITION 2011 vol. 20(4) pp. 1899-1915 GUGGISBERG A, DALAL SS, SCHNIDER A, NAGARAJAN SS Localization of cortico-peripheral coherence with electroencephalography. NEUROIMAGE 2011 vol. 57(4) pp. 1348-1357 GUGGISBERG A, DALAL SS, ZUMER JM, WONG DD, DUBOVIK S, MICHEL CM, SCHNIDER A Mapping functional connectivity in patients with brain lesions. ANNALS OF NEUROLOGY 2008 vol. 63(2) pp. 193-203 GUGGISBERG A, HONMA SM, FINDLAY AM, DALAL SS, KIRSCH HE, BERGER MS, NAGARAJAN SS Fast oscillations associated with interictal spikes localize the epileptogenic zone in patients with partial epilepsy. NEUROIMAGE 2008 vol. 39(2) pp. 661-668 GUGGISBERG A, KIRSCH HE, MANTLE MM, BARBARO NM, NAGARAJAN SS Five-dimensional neuroimaging: localization of the time-frequency dynamics of cortical activity. NEUROIMAGE 2008 vol. 40(4) pp. 1686-1700 DALAL SS AND AL. The functional relationship between yawning and vigilance. BEHAVIOURAL BRAIN RESEARCH 2007 vol. 179(1) pp. 159-166 GUGGISBERG A, MATHIS J, HERRMANN US, HESS CW The significance of the sympathetic nervous system in the pathophysiology of periodic leg movements in sleep. SLEEP 2007 vol. 30(6) pp. 755-766 GUGGISBERG A, HESS CW, MATHIS J Research's domains NEURO IMAGING