DATABASE-RESEARCH | GROUP OF CLINICAL PATIENT RESEARCH | ||||||
Karl Lothard SCHALLER | Head of group CV | Research subject | Members of the group |
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Prof. Karl Schaller HUG / Dpt NEUCLID Service neurochirurgie Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Karl.Schaller@hcuge.ch Tel.: +41 22 372 82 02 Fax: +41 22 372 82 20 Comments Pages updated the 17.11.2015 |
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GINEVRA
Ph. Bijlenga, Y. Gasche, KH Krause, F. Perren, I. Radovanovic, D. Rüfenacht, C. Schaller, B. Schalto, R. da Silva, R. Sztjazel and L. Vutskits
The Geneva Integrative NEuroVascular Research Association integrates members of basic and clinical medical sciences and focuses on in-vivo, in-vitro and in-silico research in the field of neurovascular diseases. The organ systems concerned are both the nervous and the cardiovascular system. Consequently, the specific aim of the group is to develop research that will consider both. Biological aspects are studied in animal models only where no current other method allows to perform the research aimed for. 1) Cerebro-vascular biomechanics and biology (flow related wall degeneration: role of endothelial cells and NOX family of NADPH oxidases and redox-dependent processes in vascular biology) 2) Regulation of blood-flow and metabolism (microcirculation and metabolism) Blood flow produces biomechanical forces that expose the endothelium to shear. The two factors most prominently contributing to shear stress are local hemodynamics and vessel lumen geometry. Areas of high shear, low mean shear and high oscillatory (changing) shear expose blood and vessel wall to variable stress conditions. These variable stress conditions are perceived by the vessel wall and translated into specific cellular responses that depend on each individual´s biological constitution. Endothelial cells, lining on the vessel lumen are the first cells to sense these biomechanical (flow) parameters and to translate into biological reactions. GINEVRA is focusing on the understanding of this interface. At the interface between tissue perfusion and tissue metabolism is the vessel wall of the microcirculation (blood brain barrier). Acute and chronic changes in perfusion impact the vessel wall of the microcirculation and the brain tissue involved. The governing factor at brain tissue level may well be low oxygen values that may produce a series of metabolic and hormonal changes leading to the cascade of tissue damage typically found in acute ischemia. In chronic ischemia, low oxygen values may translate into biological changes of small vessel walls as seen in veins of the white matter. GINEVRA is focusing on the understanding of the interface of circulation and brain tissue under acute and chronic low oxygen conditions Group's publications Nitrite does not provide additional protection to thrombolysis in a rat model of stroke with delayed reperfusion. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF CEREBRAL BLOOD FLOW AND METABOLISM 2008 vol. 28(3) pp. 482-489 SCHATLO B, HENNING EC, PLUTA RM, LATOUR LL, GOLPAYEGANI N, MERRILL MJ, LEWIN N, CHEN Y, OLDFIELD EH Norepinephrine and cerebral blood flow regulation in patients with arteriovenous malformations. NEUROSURGERY 2008 vol. 62(6) pp. 1254-1260 STÜER C, IKEDA T, STOFFEL M, LUIPPOLD G, SAKOWITZ O, SCHALLER K, MEYER B Effects of an aging vascular model on healthy and diseased hearts. AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY 2007 vol. 293(3) pp. 1334-1343 JEGGER D, DA SILVA RF, LARTAUD I, GAILLARD V, JEANRENAUD X, NASRATULLAH M, VON SEGESSER LK, ATKINSON J, SEGERS P, TEVAEARAI H, STERGIOPULOS N Transcriptional and post-transcriptional regulation of preproendothelin-1 by plaque-prone hemodynamics ATHEROSCLEROSIS 2007 vol. 194(2) pp. 383-390 DA SILVA RF, CHAMBAZ C, STERGIOPULOS N, HAYOZ D, SILACCI P Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase. BRAIN RESEARCH 2007 vol. 1148 pp. 217-225 GRANZIERA C, THEVENET J, PRICE M, WIEGLER K, MAGISTRETTI PJ, BADAUT J, HIRT L Oscillatory shear stress and reduced compliance impair vascular functions. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 2007 vol. 37(1-2) pp. 121-130 THACHER T, GAMBILLARA V, DA SILVA R, MONTORZI G, STERGIOPULOS N, SILACCI P PSA-NCAM in postnatally generated immature neurons of the olfactory bulb: a crucial role in regulating p75 expression and cell survival DEVELOPMENT 2007 vol. 134 pp. 1181-1190 GASCON E, VUTSKITS L, JENNY B, DURBECK P, KISS J The effect of a myocardial infarction on the normalized time-varying elastance curve. JOURNAL OF APPLIED PHYSIOLOGY 2007 vol. 102(3) pp. 1123-1129 JEGGER D, MALLIK AS, NASRATULLAH M, JEANRENAUD X, DA SILVA R, TEVAEARAI H, VON SEGESSER LK, STERGIOPULOS N Aquaporins in the brain: from aqueduct to "multi-duct". METABOLIC BRAIN DISEASE 2007 vol. 22(3-4) pp. 251-263 BADAUT J, BRUNET JF, REGLI L Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model. NEOPLASIA 2007 vol. 9(7) pp. 546-555 FERRIER MC, SARIN H, FUNG SH, SCHATLO B, PLUTA RM, GUPTA SN, CHOYKE PL, OLDFIELD EH, THOMASSON D, BUTMAN JA Subtracted vortex centers path line method with cinematic angiography for measurement of flow speed in cerebral aneurysms NEUROLOGICAL RESEARCH 2007 vol. pp. 0-0 OHTA M, FUJIMURA N, AUGSBURGER L, BARATH K, YILMAZ H, ABDO G, LOVBLAD KO, RUFENACHT DA Albumin reduces blood-brain barrier permeability but does not alter infarct size in a rat model of neonatal stroke. PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2007 vol. 62(3) pp. 261-266 WANG R, ASHWAL S, TONE B, TIAN HR, BADAUT J, RASMUSSEN A, OBENAUS A Temporal and regional evolution of aquaporin-4 expression and magnetic resonance imaging in a rat pup model of neonatal stroke. PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2007 vol. 62(3) pp. 248-254 BADAUT J, ASHWAL S, TONE B, REGLI L, TIAN HR, OBENAUS A Anomalous intracranial drainage of the nasal mucosa: A vein of the foramen caecum? AMERICAN JOURNAL OF NEURORADIOLOGY 2006 vol. 27 pp. 129-131 RUIZ DSM, GAILLOUD P, RUFENACHT DA, YILMAZ H, FASEL JHD Embolization of experimental wide-necked aneurysms with iodine-containing polyvinyl alcohol solubilized in a low-angiotoxicity solvent AMERICAN JOURNAL OF NEURORADIOLOGY 2006 vol. 27 pp. 1849-1855 DUDECK O, JORDAN O, HOFFMANN KT, OKUDUCU AF, HUSMANN I, KREUZER-NAGY T, TESMER K, PODRABSKY P, BRUHN H, HILBORN J, RUFENACHT DA, DOELKER E, FELIX R Organic solvents as vehicles for precipitating liquid embolics: A comparative angiotoxicity study with superselective injections of swine rete mirabile AMERICAN JOURNAL OF NEURORADIOLOGY 2006 vol. 27 pp. 1900-1906 DUDECK O, JORDAN O, HOFFMANN KT, OKUDUCU AF, TESMER K, KREUZER-NAGY T, RUFENACHT DA, DOELKER E, FELIX R Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine. AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY 2006 vol. 291(4) pp. 1942-1951 JEGGER D, DA SILVA R, JEANRENAUD X, NASRATULLAH M, TEVAEARAI H, VON SEGESSER LK, SEGERS P, GAILLARD V, ATKINSON J, LARTAUD I, STERGIOPULO N Thrombin in ischemic neuronal death. EXPERIMENTAL NEUROLOGY 2006 vol. 198(1) pp. 199-203 DE CASTRO RIBEIRO M, BADAUT J, PRICE M, MEINS M, BOGOUSSLAVSKY J, MONARD D, HIRT L Abnormalities in the pattern of AQP4 immunoreactivity. FASEB JOURNAL 2006 vol. 20(13) pp. 2423-2424 BADAUT J Method to quantify flow reduction in aneurysmal cavities of lateral wall aneurysms produced by stent implants used for flow diversion INTERVENTIONAL NEURORADIOLOGY 2006 vol. 12 pp. 197-200 FUJIMURA N, OHTA M, ABDO G, YLMAZ H, LOVBLAD KO, RUFENACHT DA Thee petrosquamosal sinus in humans JOURNAL OF ANATOMY 2006 vol. 209(6) pp. 711-720 SAN MILLAN RUIZ DIEGO, GAILLOUD PHILIPPE, YILMAZ HASAN, PERREN FABIENNE, RATHGEB JEAN-PAUL, RÜFENACHT DANIEL A., FASEL JEAN H.D. Intrinsically radiopaque iodine-containing polyvinyl alcohol as a liquid embolic agent: evaluation in experimental wide-necked aneurysms JOURNAL OF NEUROSURGERY 2006 vol. 104 pp. 290-297 DUDECK O, JORDAN O, HOFFMANN KT, TESMER K, KREUZER-NAGY T, PODRABSKY P, HEISE M, MEYER R, OKUDUCU AF, BRUHN H, HILBORN J, RUFENACHT DA, DOELKER E, FELIX R A lattice Boltzmann simulation of clotting in stented aneursysms and comparison with velocity or shear rate reductions MATHEMATICS AND COMPUTERS IN SIMULATION 2006 vol. 72 pp. 108-112 CHOPARD B, OUARED R, RUFENACHT DA Numerical analysis of the flow pattern in stented aneurysms and its relation to velocity reduction and stent efficiency MATHEMATICS AND COMPUTERS IN SIMULATION 2006 vol. 72 pp. 128-133 HIRABAYASHI M, OHTA M, BARATH K, RUFENACHT DA, CHOPARD B Combined IV-intra-arterial thrombolysis: A color-coded duplex pilot study NEUROLOGY 2006 vol. 67 pp. 324-326 PERREN F, LOULIDI J, GRAVES R, YILMAZ H, RUEFENACHT D, LANDIS T, SZTAJZEL R Absorption and scattering coefficient dependence of laser-Doppler flowmetry models for large tissue volumes PHYSICS IN MEDICINE AND BIOLOGY 2006 vol. 51 pp. 311-333 BINZONI T, LEUNG TS, RUFENACHT D, DELPY DT Comment on 'The use of the Henyey - Greenstein phase function in Monte Carlo simulations in biomedical optics' PHYSICS IN MEDICINE AND BIOLOGY 2006 vol. 51 pp. 39-41 BINZONI T, LEUNG TS, GANDJBAKHCHE AH, RUFENACHT D, DELPY DT The use of the Henyey-Greenstein phase function in Monte Carlo simulations in biomedical optics PHYSICS IN MEDICINE AND BIOLOGY 2006 vol. 51 pp. 313-322 BINZONI T, LEUNG TS, GANDJBAKHCHE AH, RUEFENACHT D, DELPY DT Inhibition of LINE-1 expression in the heart decreases ischemic damage by activation of Akt/PKB signaling. PHYSIOLOGICAL GENOMICS 2006 vol. 25(2) pp. 314-324 LUCCHINETTI E, FENG J, DA SILVA R, TOLSTONOG GV, SCHAUB MC, SCHUMANN GG, ZAUGG M Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC JOURNAL OF NEUROSCIENCE 2005 vol. 25(19) pp. 4879-4888 RADOVANOVIC I, BRAUN N, GIGER OT, MERTZ K, MIELE G, PRINZ M, NAVARRO B, AGUZZI A An essential function for NBS1 in the prevention of ataxia and cerebellar defects NATURE MEDICINE 2005 vol. 11(5) pp. 538-544 FRAPPART PO, TONG WM, DEMUTH I, RADOVANOVIC I, HERCEG Z, AGUZZI A, DIGWEED M, WANG ZQ Codeine intoxication associated with ultrarapid CYP2D6 metabolism NEW ENGLAND JOURNAL OF MEDICINE 2004 vol. 351 pp. 2827-2831 GASCHE Y, DAALI Y, FATHI M, CHIAPPE A, COTTINI S, DAYER P, DESMEULES J Patterns of cortical oxygen saturation changes during CO2 reactivity testing in the vicinity of cerebral arteriovenous malformations. STROKE 2003 vol. 34(4) pp. 938-944 SCHALLER K, SCHRAMM J, HAUN D, MEYER B T-type alpha 1H Ca2+ channels are involved in Ca2+ signaling during terminal differentiation (fusion) of human myoblasts. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2000 vol. 97 pp. 7627-7632 BIJLENGA P,, LIU JH, ESPINOS E, HAENGGELI CA, FISCHER-LOUGHEED J, BADER CR, BERNHEIM L Electron currents generated by the human phagocyte NADPH oxidase NATURE 1998 vol. 392 pp. 734-737 SCHRENZEL J, SERRANDER L, BANFI B, NÜSSE O, FOUYOUZI R, LEW DP, DEMAUREX N, KRAUSE KH Research's domains |