Karl Lothard SCHALLER  Head of group CV  Members of the group

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Prof. Karl Schaller
HUG / Dpt NEUCLID
Service neurochirurgie
Rue Gabrielle-Perret-Gentil 4
1211 Genève 14
Suisse

Karl.Schaller@hcuge.ch

Tel.: +41 22 372 82 02
Fax: +41 22 372 82 20




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Pages updated the 17.11.2015
Reseach's subject | Group's publications | Research's domains

GINEVRA

Ph. Bijlenga, Y. Gasche, KH Krause, F. Perren, I. Radovanovic, D. Rüfenacht, C. Schaller, B. Schalto, R. da Silva, R. Sztjazel and L. Vutskits

The Geneva Integrative NEuroVascular Research Association integrates members of basic and clinical medical sciences and focuses on in-vivo, in-vitro and in-silico research in the field of neurovascular diseases. The organ systems concerned are both the nervous and the cardiovascular system. Consequently, the specific aim of the group is to develop research that will consider both. Biological aspects are studied in animal models only where no current other method allows to perform the research aimed for.

1) Cerebro-vascular biomechanics and biology (flow related wall degeneration: role of endothelial cells and NOX family of NADPH oxidases and redox-dependent processes in vascular biology)

2) Regulation of blood-flow and metabolism (microcirculation and metabolism)
Blood flow produces biomechanical forces that expose the endothelium to shear. The two factors most prominently contributing to shear stress are local hemodynamics and vessel lumen geometry. Areas of high shear, low mean shear and high oscillatory (changing) shear expose blood and vessel wall to variable stress conditions. These variable stress conditions are perceived by the vessel wall and translated into specific cellular responses that depend on each individual´s biological constitution. Endothelial cells, lining on the vessel lumen are the first cells to sense these biomechanical (flow) parameters and to translate into biological reactions. GINEVRA is focusing on the understanding of this interface.

At the interface between tissue perfusion and tissue metabolism is the vessel wall of the microcirculation (blood brain barrier). Acute and chronic changes in perfusion impact the vessel wall of the microcirculation and the brain tissue involved. The governing factor at brain tissue level may well be low oxygen values that may produce a series of metabolic and hormonal changes leading to the cascade of tissue damage typically found in acute ischemia. In chronic ischemia, low oxygen values may translate into biological changes of small vessel walls as seen in veins of the white matter. GINEVRA is focusing on the understanding of the interface of circulation and brain tissue under acute and chronic low oxygen conditions




Group's publications

Nitrite does not provide additional protection to thrombolysis in a rat model of stroke with delayed reperfusion.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM : OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF CEREBRAL BLOOD FLOW AND METABOLISM
2008 vol. 28(3) pp. 482-489
SCHATLO B, HENNING EC, PLUTA RM, LATOUR LL, GOLPAYEGANI N, MERRILL MJ, LEWIN N, CHEN Y, OLDFIELD EH

Norepinephrine and cerebral blood flow regulation in patients with arteriovenous malformations.
NEUROSURGERY
2008 vol. 62(6) pp. 1254-1260
STÜER C, IKEDA T, STOFFEL M, LUIPPOLD G, SAKOWITZ O, SCHALLER K, MEYER B

Effects of an aging vascular model on healthy and diseased hearts.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY
2007 vol. 293(3) pp. 1334-1343
JEGGER D, DA SILVA RF, LARTAUD I, GAILLARD V, JEANRENAUD X, NASRATULLAH M, VON SEGESSER LK, ATKINSON J, SEGERS P, TEVAEARAI H, STERGIOPULOS N

Transcriptional and post-transcriptional regulation of preproendothelin-1 by plaque-prone hemodynamics
ATHEROSCLEROSIS
2007 vol. 194(2) pp. 383-390
DA SILVA RF, CHAMBAZ C, STERGIOPULOS N, HAYOZ D, SILACCI P

Thrombin-induced ischemic tolerance is prevented by inhibiting c-jun N-terminal kinase.
BRAIN RESEARCH
2007 vol. 1148 pp. 217-225
GRANZIERA C, THEVENET J, PRICE M, WIEGLER K, MAGISTRETTI PJ, BADAUT J, HIRT L

Oscillatory shear stress and reduced compliance impair vascular functions.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2007 vol. 37(1-2) pp. 121-130
THACHER T, GAMBILLARA V, DA SILVA R, MONTORZI G, STERGIOPULOS N, SILACCI P

PSA-NCAM in postnatally generated immature neurons of the olfactory bulb: a crucial role in regulating p75 expression and cell survival
DEVELOPMENT
2007 vol. 134 pp. 1181-1190
GASCON E, VUTSKITS L, JENNY B, DURBECK P, KISS J

The effect of a myocardial infarction on the normalized time-varying elastance curve.
JOURNAL OF APPLIED PHYSIOLOGY
2007 vol. 102(3) pp. 1123-1129
JEGGER D, MALLIK AS, NASRATULLAH M, JEANRENAUD X, DA SILVA R, TEVAEARAI H, VON SEGESSER LK, STERGIOPULOS N

Aquaporins in the brain: from aqueduct to "multi-duct".
METABOLIC BRAIN DISEASE
2007 vol. 22(3-4) pp. 251-263
BADAUT J, BRUNET JF, REGLI L

Validation of dynamic contrast-enhanced magnetic resonance imaging-derived vascular permeability measurements using quantitative autoradiography in the RG2 rat brain tumor model.
NEOPLASIA
2007 vol. 9(7) pp. 546-555
FERRIER MC, SARIN H, FUNG SH, SCHATLO B, PLUTA RM, GUPTA SN, CHOYKE PL, OLDFIELD EH, THOMASSON D, BUTMAN JA

Subtracted vortex centers path line method with cinematic angiography for measurement of flow speed in cerebral aneurysms
NEUROLOGICAL RESEARCH
2007 vol. pp. 0-0
OHTA M, FUJIMURA N, AUGSBURGER L, BARATH K, YILMAZ H, ABDO G, LOVBLAD KO, RUFENACHT DA

Albumin reduces blood-brain barrier permeability but does not alter infarct size in a rat model of neonatal stroke.
PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION
2007 vol. 62(3) pp. 261-266
WANG R, ASHWAL S, TONE B, TIAN HR, BADAUT J, RASMUSSEN A, OBENAUS A

Temporal and regional evolution of aquaporin-4 expression and magnetic resonance imaging in a rat pup model of neonatal stroke.
PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION
2007 vol. 62(3) pp. 248-254
BADAUT J, ASHWAL S, TONE B, REGLI L, TIAN HR, OBENAUS A

Anomalous intracranial drainage of the nasal mucosa: A vein of the foramen caecum?
AMERICAN JOURNAL OF NEURORADIOLOGY
2006 vol. 27 pp. 129-131
RUIZ DSM, GAILLOUD P, RUFENACHT DA, YILMAZ H, FASEL JHD

Embolization of experimental wide-necked aneurysms with iodine-containing polyvinyl alcohol solubilized in a low-angiotoxicity solvent
AMERICAN JOURNAL OF NEURORADIOLOGY
2006 vol. 27 pp. 1849-1855
DUDECK O, JORDAN O, HOFFMANN KT, OKUDUCU AF, HUSMANN I, KREUZER-NAGY T, TESMER K, PODRABSKY P, BRUHN H, HILBORN J, RUFENACHT DA, DOELKER E, FELIX R

Organic solvents as vehicles for precipitating liquid embolics: A comparative angiotoxicity study with superselective injections of swine rete mirabile
AMERICAN JOURNAL OF NEURORADIOLOGY
2006 vol. 27 pp. 1900-1906
DUDECK O, JORDAN O, HOFFMANN KT, OKUDUCU AF, TESMER K, KREUZER-NAGY T, RUFENACHT DA, DOELKER E, FELIX R

Ventricular-arterial coupling in a rat model of reduced arterial compliance provoked by hypervitaminosis D and nicotine.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY
2006 vol. 291(4) pp. 1942-1951
JEGGER D, DA SILVA R, JEANRENAUD X, NASRATULLAH M, TEVAEARAI H, VON SEGESSER LK, SEGERS P, GAILLARD V, ATKINSON J, LARTAUD I, STERGIOPULO N

Thrombin in ischemic neuronal death.
EXPERIMENTAL NEUROLOGY
2006 vol. 198(1) pp. 199-203
DE CASTRO RIBEIRO M, BADAUT J, PRICE M, MEINS M, BOGOUSSLAVSKY J, MONARD D, HIRT L

Abnormalities in the pattern of AQP4 immunoreactivity.
FASEB JOURNAL
2006 vol. 20(13) pp. 2423-2424
BADAUT J

Method to quantify flow reduction in aneurysmal cavities of lateral wall aneurysms produced by stent implants used for flow diversion
INTERVENTIONAL NEURORADIOLOGY
2006 vol. 12 pp. 197-200
FUJIMURA N, OHTA M, ABDO G, YLMAZ H, LOVBLAD KO, RUFENACHT DA

Thee petrosquamosal sinus in humans
JOURNAL OF ANATOMY
2006 vol. 209(6) pp. 711-720
SAN MILLAN RUIZ DIEGO, GAILLOUD PHILIPPE, YILMAZ HASAN, PERREN FABIENNE, RATHGEB JEAN-PAUL, RÜFENACHT DANIEL A., FASEL JEAN H.D.

Intrinsically radiopaque iodine-containing polyvinyl alcohol as a liquid embolic agent: evaluation in experimental wide-necked aneurysms
JOURNAL OF NEUROSURGERY
2006 vol. 104 pp. 290-297
DUDECK O, JORDAN O, HOFFMANN KT, TESMER K, KREUZER-NAGY T, PODRABSKY P, HEISE M, MEYER R, OKUDUCU AF, BRUHN H, HILBORN J, RUFENACHT DA, DOELKER E, FELIX R

A lattice Boltzmann simulation of clotting in stented aneursysms and comparison with velocity or shear rate reductions
MATHEMATICS AND COMPUTERS IN SIMULATION
2006 vol. 72 pp. 108-112
CHOPARD B, OUARED R, RUFENACHT DA

Numerical analysis of the flow pattern in stented aneurysms and its relation to velocity reduction and stent efficiency
MATHEMATICS AND COMPUTERS IN SIMULATION
2006 vol. 72 pp. 128-133
HIRABAYASHI M, OHTA M, BARATH K, RUFENACHT DA, CHOPARD B

Combined IV-intra-arterial thrombolysis: A color-coded duplex pilot study
NEUROLOGY
2006 vol. 67 pp. 324-326
PERREN F, LOULIDI J, GRAVES R, YILMAZ H, RUEFENACHT D, LANDIS T, SZTAJZEL R

Absorption and scattering coefficient dependence of laser-Doppler flowmetry models for large tissue volumes
PHYSICS IN MEDICINE AND BIOLOGY
2006 vol. 51 pp. 311-333
BINZONI T, LEUNG TS, RUFENACHT D, DELPY DT

Comment on 'The use of the Henyey - Greenstein phase function in Monte Carlo simulations in biomedical optics'
PHYSICS IN MEDICINE AND BIOLOGY
2006 vol. 51 pp. 39-41
BINZONI T, LEUNG TS, GANDJBAKHCHE AH, RUFENACHT D, DELPY DT

The use of the Henyey-Greenstein phase function in Monte Carlo simulations in biomedical optics
PHYSICS IN MEDICINE AND BIOLOGY
2006 vol. 51 pp. 313-322
BINZONI T, LEUNG TS, GANDJBAKHCHE AH, RUEFENACHT D, DELPY DT

Inhibition of LINE-1 expression in the heart decreases ischemic damage by activation of Akt/PKB signaling.
PHYSIOLOGICAL GENOMICS
2006 vol. 25(2) pp. 314-324
LUCCHINETTI E, FENG J, DA SILVA R, TOLSTONOG GV, SCHAUB MC, SCHUMANN GG, ZAUGG M

Truncated prion protein and Doppel are myelinotoxic in the absence of oligodendrocytic PrPC
JOURNAL OF NEUROSCIENCE
2005 vol. 25(19) pp. 4879-4888
RADOVANOVIC I, BRAUN N, GIGER OT, MERTZ K, MIELE G, PRINZ M, NAVARRO B, AGUZZI A

An essential function for NBS1 in the prevention of ataxia and cerebellar defects
NATURE MEDICINE
2005 vol. 11(5) pp. 538-544
FRAPPART PO, TONG WM, DEMUTH I, RADOVANOVIC I, HERCEG Z, AGUZZI A, DIGWEED M, WANG ZQ

Codeine intoxication associated with ultrarapid CYP2D6 metabolism
NEW ENGLAND JOURNAL OF MEDICINE
2004 vol. 351 pp. 2827-2831
GASCHE Y, DAALI Y, FATHI M, CHIAPPE A, COTTINI S, DAYER P, DESMEULES J

Patterns of cortical oxygen saturation changes during CO2 reactivity testing in the vicinity of cerebral arteriovenous malformations.
STROKE
2003 vol. 34(4) pp. 938-944
SCHALLER K, SCHRAMM J, HAUN D, MEYER B

T-type alpha 1H Ca2+ channels are involved in Ca2+ signaling during terminal differentiation (fusion) of human myoblasts.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
2000 vol. 97 pp. 7627-7632
BIJLENGA P,, LIU JH, ESPINOS E, HAENGGELI CA, FISCHER-LOUGHEED J, BADER CR, BERNHEIM L

Electron currents generated by the human phagocyte NADPH oxidase
NATURE
1998 vol. 392 pp. 734-737
SCHRENZEL J, SERRANDER L, BANFI B, NÜSSE O, FOUYOUZI R, LEW DP, DEMAUREX N, KRAUSE KH


Research's domains