DATABASE-RESEARCH | GROUP OF CLINICAL PATIENT RESEARCH | ||||||
S. HARBARTH | Head of group CV | Research subject | Members of the group |
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Prof. Stephan HARBARTH HUG Direction Médicale Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Stephan.Harbarth@hcuge.ch Tel.: 022 372 33 57 Comments Pages updated the 17.11.2015 |
Reseach's subject
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Group's publications
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Research's domains
MRSA
Since the last third of 1999, Geneva University Hospitals (HUG) have experienced resurgence of the previously controlled MRSA epidemic. In 2000, the incidence of MRSA (infected and colonized
patients) has markedly increased over its peak value before control measures were implemented in 1994. The grave consequences of the epidemic, both for hospitalized patients and the institution have been
extensively described. Briefly, hyperendemicity has led to a 4-fold increase in rate of MRSA bloodstream infection in 2000-2001, compared with annual rates during 1996-1998.
New cases are essentially the result of cross-transmission. These cases could have been prevented with adequate hand hygiene and contact isolation. A major obstacle to prompt isolation is the large unrecognized MRSA reservoir circulating among healthcare facilities. Ample evidence suggests that the early detection of occult MRSA carriers admitted in the hospital is a crucial step in controlling nosocomial transmission infection. It is probable that by defining a specific risk-profile for admission-carriage of MRSA, a significantly lower percentage of admissions could be screened to detect the potential reservoir admitted at HUG. A targeted screening of high-risk patients (combined with a rapid detection technique) would facilitate planning for timely isolation while minimizing disruption in patient care. We therefore conduct different studies to evaluate the high-risk profile for on-admission carriage of MRSA and improve patient safety by early isolation. Group's publications Quasiexperimental study of the effects of antibiotic use, gastric acid-suppressive agents, and infection control practices on the incidence of Clostridium difficile-associated diarrhea in hospitalized patients. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2009 vol. 53(5) pp. 2082-2088 ALDEYAB MA, HARBARTH S, VERNAZ N, KEARNEY MP, SCOTT MG, FUNSTON C, SAVAGE K, KELLY D, ALDIAB MA, MCELNAY JC Adequacy of antimicrobial treatment and outcome of Staphylococcus aureus bacteremia in 9 Western European countries. CLINICAL INFECTIOUS DISEASES 2009 vol. 49(7) pp. 997-1005 AMMERLAAN HS AND AL. Gram-Negative Bacteremia upon Hospital Admission: When Should Pseudomonas aeruginosa Be Suspected? CLINICAL INFECTIOUS DISEASES 2009 vol. 48(5) pp. 580-586 SCHECHNER V. AND AL. Navigating the Web in Search of Resources on Antimicrobial Stewardship in Health Care Institutions CLINICAL INFECTIOUS DISEASES 2009 vol. 48(5) pp. 626-632 PAGANI L, GYSSENS IC, HUTTNER B, NATHWANI D, HARBARTH S Community-associated methicillin-resistant Staphylococcus aureus: risk factors for infection, and long-term follow-up. CLINICAL MICROBIOLOGY AND INFECTION 2009 vol. 15(6) pp. 552-559 LONGTIN Y, SUDRE P, FRANCOIS P, SCHRENZEL J, ARAMBURU C, PASTOR R, GERVAIX A, RENZI G, PITTET D, HARBARTH S Management of methicillin-resistant Staphylococcus aureus infections. CLINICAL MICROBIOLOGY AND INFECTION 2009 vol. 15(2) pp. 125-136 GARAU J, BOUZA E, CHASTRE J, GUDIOL F, HARBARTH S When once is not enough--further evidence of procalcitonin-guided antibiotic stewardship. CRITICAL CARE 2009 vol. 13(4) pp. 165-165 HARBARTH S, ALBRICH WC, MULLER B Methicillin-resistant Staphylococcus aureus decolonization: "yes, we can," but will it help? INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2009 vol. 30(7) pp. 633-635 KLUYTMANS J, HARBARTH S Impact of a Short Period of Pre-Enrichment on Detection and Bacterial Loads of Methicillin-Resistant Staphylococcus aureus from Screening Specimens JOURNAL OF CLINICAL MICROBIOLOGY 2009 vol. 47(10) pp. 3326-3328 VAN HEIRSTRAETEN L, CORTIÑAS ABRAHANTES J, LAMMENS C, LEE A, HARBARTH S, MOLENBERGHS G, AERTS M, GOOSSENS H, MALHOTRA-KUMAR S Poor utility of MRSA screening to predict staphylococcal species in orthopaedic implant infections JOURNAL OF HOSPITAL INFECTION 2009 vol. 73(1) pp. 89-91 UCKAY I, TETERYCZ D, FERRY T, HARBARTH S, LUBBEKE A, EMONET STEPHANE, CHILCOTT M, HOFFMEYER P, BERNARD L "Antibiotics are not automatic anymore"--the French national campaign to cut antibiotic overuse. PLOS MEDICINE 2009 vol. 6(6) pp. 1000080-1000080 HUTTNER B, HARBARTH S Surveillance of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in a Swiss Tertiary Care Hospital. SWISS MEDICAL WEEKLY 2009 vol. 139(51-52) pp. 747-751 FANKHAUSER C, ZINGG W, FRANCOIS P, DHARAN S, SCHRENZEL J, PITTET D, HARBARTH S Activity and impact on antibiotic use and costs of a dedicated infectious diseases consultant on a septic orthopaedic unit. THE JOURNAL OF INFECTION 2009 vol. 58(3) pp. 205-212 UCKAY I, VERNAZ-HEGI N, HARBARTH S, STERN R, LEGOUT L, VAUTHEY L, FERRY T, LUBBEKE A, ASSAL M, LEW D, HOFFMEYER P, BERNARD L Re: help or hindrance? Is current infection control advice applicable in low- and middle-income countries? A review of the literature. AMERICAN JOURNAL OF INFECTION CONTROL 2008 vol. 36(7) pp. 499-501 STORR J, PITTET D Use of procalcitonin to shorten antibiotic treatment duration in septic patients: a randomized trial. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2008 vol. 177(5) pp. 498-505 NOBRE V, HARBARTH S, GRAF JEAN-DANIEL, ROHNER P, PUGIN J Novel microarray design strategy to study complex bacterial communities. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2008 vol. 74(6) pp. 1876-1885 HUYGHE ANTOINE, FRANCOIS P, CHARBONNIER YVAN, BENTO M, BONETTI EJ, PASTER BJ, BOLIVAR I, BARATTI-MAYER D, PITTET D, SCHRENZEL J Ventilator-associated pneumonia as a quality indicator for patient safety? CLINICAL INFECTIOUS DISEASES 2008 vol. 46(4) pp. 557-563 UCKAY ILKER, AHMED QA, SAX H, PITTET D Healthcare-associated infections: think globally, act locally. CLINICAL MICROBIOLOGY AND INFECTION 2008 vol. 14(10) pp. 895-907 MARCEL JP AND AL. Healthcare-associated infections in neonates. CURRENT OPINION IN INFECTIOUS DISEASES 2008 vol. 21(3) pp. 228-234 ZINGG W, POSFAY-BARBE KLARA, PITTET D Methicillin-resistant Staphylococcus aureus control in the 21st century: beyond the acute care hospital. CURRENT OPINION IN INFECTIOUS DISEASES 2008 vol. 21(4) pp. 372-379 NAVARRO M, HUTTNER B, HARBARTH S Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993-2005. EMERGING INFECTIOUS DISEASES (PRINT) 2008 vol. 14(2) pp. 304-307 FRANCOIS P, HARBARTH S, HUYGHE ANTOINE, RENZI G, BENTO M, GERVAIX A, PITTET D, SCHRENZEL J Commentary: hand hygiene: it's all about when and how. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 2008 vol. 29(10) pp. 957-959 PITTET D Trial of alcohol-based hand gel in critical care units. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 2008 vol. 29(6) pp. 577-579 MERMEL LA, BOYCE JM, VOSS A, ALLEGRANZI B, PITTET D Effect of screening for methicillin-resistant Staphylococcus aureus carriage by polymerase chain reaction on the duration of unnecessary preemptive contact isolation. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2008 vol. 29(11) pp. 1077-1079 UCKAY ILKER, SAX H, ITEN A, CAMUS V, RENZI G, SCHRENZEL J, PERRIER A, PITTET D Risk factors for methicillin-resistant Staphylococcus aureus surgical site infection. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2008 vol. 29(9) pp. 890-893 HARBARTH S, HUTTNER B, GERVAZ P, FANKHAUSER C, CHRAITI MARIE-NOELLE, SCHRENZEL J, LICKER M, PITTET D Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA 2008 vol. 299(10) pp. 1149-1157 HARBARTH S, FANKHAUSER C, SCHRENZEL J, CHRISTENSON JAN, GERVAZ P, BANDIERA-CLERC C, RENZI G, VERNAZ N, SAX H, PITTET D Antibiotic prophylaxis before invasive dental procedures in patients with arthroplasties of the hip and knee. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME 2008 vol. 90(7) pp. 833-838 UCKAY ILKER, PITTET D, BERNARD L, LEW D, PERRIER A, PETER R Infection control as a major World Health Organization priority for developing countries. JOURNAL OF HOSPITAL INFECTION 2008 vol. ;68(4) pp. 285-292 PITTET D, ALLEGRANZI B, STORR J, BAGHERI NEJAD S, DZIEKAN G, LEOTSAKOS A, DONALDSON L Multi-resistant infections in repatriated patients after natural disasters: lessons learned from the 2004 tsunami for hospital infection control. JOURNAL OF HOSPITAL INFECTION 2008 vol. 68(1) pp. 1-8 UCKAY ILKER, SAX H, HARBARTH S, BERNARD L, PITTET D Rapid and high-throughput genotyping of Staphylococcus epidermidis isolates by automated multilocus variable-number of tandem repeats: a tool for real-time epidemiology. JOURNAL OF MICROBIOLOGICAL METHODS 2008 vol. 72(3) pp. 296-305 FRANCOIS P, HOCHMANN A, HUYGHE ANTOINE, BONETTI EJ, RENZI G, HARBARTH S, KLINGENBERG C, PITTET D, SCHRENZEL J A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 2008 vol. 207(5) pp. 683-689 HARBARTH S, SAX H, UCKAY I, FANKHAUSER C, AGOSTINHO A, CHRISTENSON JT, RENZI G, SCHRENZEL J, PITTET D Rapid identification of hospitalized patients at high risk for MRSA carriage. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION : JAMIA 2008 vol. 15(4) pp. 506-512 EVANS RS AND AL. Community-acquired methicillin-resistant Staphylococcus aureus infections in two scuba divers returning from the Philippines. JOURNAL OF TRAVEL MEDICINE : OFFICIAL PUBLICATION OF THE INTERNATIONAL SOCIETY OF TRAVEL MEDICINE AND THE ASIA PACIFIC TRAVEL HEALTH ASSOCIATION 2008 vol. 15(5) pp. 378-381 BOCHET M, FRANCOIS P, LONGTIN Y, GAIDE O, RENZI G, HARBARTH S Preventing infections acquired during health-care delivery. LANCET 2008 vol. 372(9651) pp. 1719-1720 PITTET D, ALLEGRANZI B Alcohol-based rubs for hand antisepsis. LANCET INFECTIOUS DISEASES 2008 vol. 8(10) pp. 585-586 PITTET D, DHARAN S Infection control in paediatrics. LANCET INFECTIOUS DISEASES 2008 vol. ;8(1) pp. 19-31 POSFAY-BARBE, ZERR DM, PITTET D Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study. SPINE 2008 vol. 33(18) pp. 1919-1924 PETIGNAT C AND AL. Comment on: Control of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae using a computer-assisted management program to restrict third-generation cephalosporin use. THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2008 vol. 62(5) pp. 1165-1165 HUTTNER B, PITTET D, HARBARTH S Interventions to control MRSA: high time for time-series analysis? THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2008 vol. 62(3) pp. 431-433 HARBARTH S, SAMORE MH Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile. THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2008 vol. 62(3) pp. 601-607 VERNAZ N, SAX H, PITTET D, BONNABRY P, SCHRENZEL J, HARBARTH S Procalcitonin guided antibiotic therapy and hospitalization in patients with lower respiratory tract infections: a prospective, multicenter, randomized controlled trial BMC HEALTH SERVICES RESEARCH 2007 vol. 7 pp. 102- SCHUETZ P, CHRIST-CRAIN M, WOLBERS M, SCHILD U, THOMANN R, FALCONNIER C, WIDMER I, NEIDERT S, BLUM CA, SCHÖNENBERGER R, HENZEN C, BREGENZER T, HOESS C, KRAUSE M, BUCHER HC, ZIMMERLI W, MÜLLER B, PROHOSP STUDY GROUP Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia BMC INFECTIOUS DISEASES 2007 vol. 7 pp. 0-0 MULLER, B, HARBARTH STEPHAN, STOLZ, D, BINGISSER, R, MUELLER, C, LEUPPI, J, NUSBAUMER, C, TAMM, M, CHRIST-CRAIN, M Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia BMC INFECTIOUS DISEASES 2007 vol. 2 pp. 7-10 MULLER B, HARBARTH S, STOLZ D, BINGISSER R, MUELLER C, LEUPPI J, NUSBAUMER C, TAMM M, CHRIST-CRAIN M Does antibiotic selection impact patient outcome? CLINICAL INFECTIOUS DISEASES 2007 vol. 44 pp. 87-93 HARBARTH S, NOBRE V, PITTET D Paediatricians' perception of antibiotic use in children in two large Swiss cities INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2007 vol. 30 pp. 281-283 GERVAIX A, EGGER M, LACROIX L, HARBARTH S Prevention of primary bacteraemia INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2007 vol. 30 pp. 80-87 JUAN-TORRES, A, HARBARTH, S Evaluation of three molecular assays for rapid identification of methicillin-resistant Staphylococcus aureus JOURNAL OF CLINICAL MICROBIOLOGY 2007 vol. 45 pp. 2011-2013 FRANCOIS P, BENTO M, RENZI G, HARBARTH S, PITTET D, SCHRENZEL J Evaluation of three molecular assays for rapid identification of methicillin-resistant Staphylococcus aureus JOURNAL OF CLINICAL MICROBIOLOGY 2007 vol. 45(6) pp. 2011-2013 Is throat screening necessary to detect methicillin-resistant Staphylococcus aureus colonization in patients upon admission to an intensive care unit? JOURNAL OF CLINICAL MICROBIOLOGY 2007 vol. 45 pp. 1072-1073 HARBARTH S, SCHRENZEL J, RENZI G, AKAKPO C, RICOU B Management of a large healthcare-associated outbreak of Panton-Valentine leucocidin-positive meticillin-resistant Staphylococcus aureus in Germany JOURNAL OF HOSPITAL INFECTION 2007 vol. 67(2) pp. 114-120 WAGENLEHNER FM, NABER KG, BAMBL E, RAAB U, WAGENLEHNER C, KAHLAU D, HÖLLER C, WITTE W, WEIDNER W, LEHN N, HARBARTH S, LINDE HJ A simulation-based evaluation of methods to estimate the impact of an adverse event on hospital length of stay MEDICAL CARE 2007 vol. 45 pp. 108-115 SAMORE, MH, SHEN, S, GREENE, T, STODDARD, G, SAUER, B, SHINOGLE, J, NEBEKER, J, HARBARTH, S Skin reactions related to hand hygiene and selection of hand hygiene products AMERICAN JOURNAL OF INFECTION CONTROL 2006 vol. 34 pp. 627-635 LARSON E, GIRARD R, PESSOA-SILVA CL, BOYCE J, DONALDSON L, PITTET D Evaluating the probability of previously unknown carriage of MRSA at hospital admission AMERICAN JOURNAL OF MEDICINE 2006 vol. 119(3) pp. 275-275 HARBARTH S, SAX H, FANKHAUSER-RODRIGUEZ C, SCHRENZEL J, AGOSTINHO A, PITTET D A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006 vol. 173 pp. 91-97 KOLLEF M, PITTET D, GARCIA MS, CHASTRE J, FAGON JY, BONTEN M, HYZY R, FLEMING TR, FUCHS H, BELLM L, MERCAT A, MANEZ R, MARTINEZ A, EGGIMANN P, DAGUERRE M, LUYT CE Procalcitonin Guidance of Antibiotic Therapy in Community-acquired Pneumonia: A Randomized Trial AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006 vol. 174(1) pp. 84-93 CHRIST-CRAIN MIRJAM ET AL. Procalcitonin guidance of antibiotic therapy in community-acquired pneumonia: a randomized trial AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006 vol. 174(1) pp. 84-93 CHRIST-CRAIN M, STOLZ D, BINGISSER R, MULLER CHRISTIAN, MIEDINGER D, HUBER PR, ZIMMERLI W, HARBARTH S, TAMM M, MÜLLER B Navigating the world wide web in search of resources on antimicrobial resistance CLINICAL INFECTIOUS DISEASES 2006 vol. 43 pp. 72-78 HARBARTH S, EMONET S Reduction of urinary tract infection and antibiotic use after surgery: A controlled, prospective, befor after intervention study CLINICAL INFECTIOUS DISEASES 2006 vol. 42 pp. 1544-1551 STEPHAN F, SAX H, WACHSMUTH M, HOFFMEYER P, CLERGUE F, PITTET D Control of endemic methicillin-resistant Staphylococcus aureus - recent advances and future challenges CLINICAL MICROBIOLOGY AND INFECTION 2006 vol. 12 pp. 1154-1162 HARBARTH S Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study CRITICAL CARE 2006 vol. 10 pp. 0-0 HARBARTH S, MASUET-AUMATELL C, SCHRENZEL J, FRANCOIS P, AKAKPO C, RENZI G, PUGIN J, RICOU B, PITTET D Primary invasive aspergillosis of the digestive tract: report of two cases and review of the literature INFECTION 2006 vol. 34(6) pp. 333-338 EGGIMANN PHILIPPE, CHEVROLET JEAN-CLAUDE, STAROBINSKI M, MAJNO PIETRO, TOTSCH MARTIN, CHAPUIS BERNARD, PITTET DIDIER Outbreak of endophthalmitis after cataract surgery: the importance of the quality of the surgical wound INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2006 vol. 27(11) pp. 1246-1248 HUGONNET STEPHANE, DOSSO ANDRE, DHARAN SASI, MARTIN YVES, HERRERO MARIA-LUISA, REGNIER CAROLE, PITTET DIDIER Challenging the world: patient safety and health care-associated infection INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE 2006 vol. 18 pp. 4-8 PITTET D, DONALDSON L Clean care is safer care': the Global Patient Safety Challenge 2005-2006 INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2006 vol. 10 pp. 419-424 PITTET D, ALLEGRANZI B, STORR J, DONALDSON L Muslim health-care workers and alcohol-based handrubs LANCET 2006 vol. 367 pp. 1025-1027 AHMED QA, MEMISH ZA, ALLEGRANZI B, PITTET D Evidence-based model for hand transmission during patient care and the role of improved practices LANCET INFECTIOUS DISEASES 2006 vol. 6(10) pp. 641-652 PITTET D, ALLEGRANZI B, SAX H, DHARAN S, PESSOA-SILVA CL, DONALDSON L, BOYCE JM Postoperative fungal infections SURGICAL INFECTIONS 2006 vol. 7 Suppl 2 pp. 53-56 EGGIMANN PHILIPPE, PITTET DIDIER Treatment options of invasive fungal infections in adults SWISS MEDICAL WEEKLY 2006 vol. 136 pp. 447-463 FLUCKIGER U, MARCHETTI O, BILLE J, EGGIMANN P, ZIMMERLI S, IMHOF A, GARBINO J, RUE C, PITTET D, TAUBER M, GLAUSER M, CALANDRA T Prevalence and prediction of previously unknown MRSA carriage on admission to a geriatric hospital AGE AND AGEING 2005 vol. 34 pp. 456-462 SAX HUGO, HARBARTH STEPHAN, GAVAZZI GAETAN, HENRY NICOLE, SCHRENZEL JACQUES, ROHNER PETER, MICHEL JEAN-PIERRE, PITTET DIDIER Clean Care is safer care: the first global challenge of the WHO World Alliance for Patient Safety AMERICAN JOURNAL OF INFECTION CONTROL 2005 vol. 33 pp. 476-479 PITTET DIDIER, DONALDSON L Comparative efficacy of hand hygiene agents in the reduction of bacteria and viruses AMERICAN JOURNAL OF INFECTION CONTROL 2005 vol. 33 pp. 558-560 ROTTER M, SATTAR SA, DHARAN S, WEBBER P, VOSS A, PITTET DIDIER Infection control and quality health care in the new millenium AMERICAN JOURNAL OF INFECTION CONTROL 2005 vol. 33 pp. 258-267 PITTET DIDIER Long-term reduction of vascular access-associated bloodstream infection ANNALS OF INTERNAL MEDICINE 2005 vol. pp. 875-876 EGGIMANN PHILIPPE, HUGONNET STEPHANE, SAX HUGO, HARBARTH STEPHAN, CHEVROLET JEAN-CLAUDE, PITTET DIDIER Ethics roundtable debate: A patient dies from an ICU-acquired infection related to methicillin-resistant Staphylococcus aureus--how do you defend your case and your team? CRITICAL CARE 2005 vol. 9(1) pp. 5-9 VINCENT JL, BRUN-BUISSON C, NIEDERMAN M, HAENNI C, HARBARTH S, SPRUMONT D, VALENCIA M, TORRES A Mid-regional pro-adrenomedullin as a prognostic marker in sepsis: an observational study CRITICAL CARE 2005 vol. 9 pp. 816-824 CHRIST-CRAIN M, MORGENTHALER NG, STRUCK J, HARBARTH STEPHAN, BERGMANN A, MULLER B Antimicrobial resistance determinants and future control EMERGING INFECTIOUS DISEASES (PRINT) 2005 vol. 11 pp. 794-801 HARBARTH STEPHAN, SAMORE MH Community-associated methicillin-resistant Staphylococcus aureus, Switzerland EMERGING INFECTIOUS DISEASES (PRINT) 2005 vol. 11 pp. 962-965 HARBARTH STEPHAN, FRANCOIS PATRICE, SCHRENZEL JACQUES, FANKHAUSER-RODRIGUEZ CAROLINA, HUGONNET STEPHANE, KOESSLER THIBAUD, HUYGHE ANTOINE, PITTET DIDIER Lack of effect of antibiotic combination therapy on mortality in patients with pneumococcal sepsis EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 2005 vol. pp. 688-690 Lack of effect of combination antibiotic therapy on mortality in patients with pneumococcal sepsis. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 2005 vol. 24 pp. 688-690 HARBARTH STEPHAN, GARBINO JORGE, PUGIN JEROME, ROMAND JACQUES-ANDRE, PITTET DIDIER Knowledge of standard and isolation precautions in a large teaching hospital INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 2005 vol. pp. 298-304 SAX HUGO, PERNEGER THOMAS, HUGONNET STEPHANE, HERRAULT PASCALE, CHRAITI MARIE-NOELLE, PITTET DIDIER Attitudes and perceptions toward hand hygiene among healthcare workers caring for critically ill neonates INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2005 vol. 26 pp. 305-311 PESSOA DA SILVA CARMEN, POSFAY-BARBE KLARA, PFISTER RICCARDO, TOUVENEAU SYLVIE, PERNEGER THOMAS, PITTET DIDIER Clean Care is Safer Care: the first global challenge of the WHO World Alliance for Patient Safety INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2005 vol. 26 pp. 891-894 PITTET DIDIER, DONALDSON L Nosocomial bacteremia: clinical significance of a single blood culture positive for coagulase-negative staphylococci INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2005 vol. 26(8) pp. 697-702 FAVRE BERTRAND, HUGONNET STEPHANE, CORREA FELIU LILIANA, SAX HUGO, ROHNER PETER, PITTET DIDIER The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2005 vol. 26(2) pp. 166-174 COSGROVE SE, QI Y, KAYE KS, HARBARTH S, KARCHMER AW, CARMELI Y Invasive candidiasis: comparison of management choices by infectious disease and critical care specialists INTENSIVE CARE MEDICINE 2005 vol. 31 pp. 1514-1521 GARBINO JORGE, PITTET DIDIER Use of an automated multiple-locus, variable-number tandem repeat-based method for rapid and high-throughput genotyping of Staphylococcus aureus isolates JOURNAL OF CLINICAL MICROBIOLOGY 2005 vol. 43 pp. 3346-3355 FRANCOIS PATRICE, HUYGHE ANTOINE, CHARBONNIER YVAN, BENTO MANUELA, HERZIG SEBASTIEN, TOPOLSKI IVAN, FLEURY BENEDICTE, LEW DANIEL, VAUDAUX PIERRE, HARBARTH STEPHAN, VAN LEEUWEN WILLEM, VAN BELKUM ALEX, BLANC D.S., PITTET DIDIER, SCHRENZEL JACQUES Pasteurella multocida endophthalmitis: case report and review of the literature. KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE 2005 vol. 222(3) pp. 231-233 DANG BURGENER NP., BAGLIVO EDOARDO, HARBARTH STEPHAN, SAHABO CHRISTOPHE, PITTET DIDIER, SAFRAN AVINOAM Clean Care is Safer Care: a worldwide priority LANCET 2005 vol. 366 pp. 1246-1247 PITTET DIDIER, DONALDSON L Clean hands reduce the burden of disease LANCET 2005 vol. 366(9481) pp. 185-187 PITTET DIDIER Considerations for a WHO European strategy on health-care-associated infection, surveillance, and control LANCET INFECTIOUS DISEASES 2005 vol. 5(4) pp. 242-250 PITTET D. ET AL. Meticillin-resistant Staphylococcus aureus LANCET INFECTIOUS DISEASES 2005 vol. 5(10) pp. 653-663 BOYCE JM, COOKSON B, CHRISTIANSEN K, HORI S, VUOPIO-VARKILA J, KOCAGÖZ S, OZTOP AY, VANDENBROUCKE-GRAULS CM, HARBARTH S, PITTET D Infection and rejection in liver transplant patients: a 10-year Swiss single-centre experience SWISS MEDICAL WEEKLY 2005 vol. 135 pp. 587-593 GARBINO JORGE, ROMAND JACQUES-ANDRE, PITTET DIDIER, GIOSTRA EMILIANO, MENTHA GILLES, SUTER PETER M Considerations for a WHO European strategy on health-care-associated infection, surveillance and control THE LANCET INFECTIOUS DISEASES 2005 vol. 5 pp. 242-250 PITTET DIDIER, ALLENGRANZI B, SAX HUGO, BERTINATO L, CONCIA E, COOKSON B, FABRY J, RICHET H, PHILIP P, SPENCER RC, GANTER BW, LAZZARI S Infection in breast implants THE LANCET INFECTIOUS DISEASES 2005 vol. 5 pp. 94-106 PITTET-CUENOD BRIGITTE, MONTANDON DENYS, PITTET DIDIER Consequences of an unsufficient range of immunity in "pediatric" infectious diseases--example with measles THERAPEUTISCHE UMSCHAU : MONATSSCHRIFT FUER PRAKTISCHE MEDIZIN = REVUE THERAPEUTIQUE : REVUE MENSUELLE DE MEDECINE PRATIQUE 2005 vol. 62(10) pp. 679-684 UCKAY ILKER, SAX HUGO, HUGONNET STEPHANE, ARAMBURU C, BESSIRE N, RUTSCHMANN OLIVIER, KAISER LAURENT, GERVAIX ALAIN, SUDRE PHILIPPE, SIEGRIST CLAIRE-ANNE, PITTET DIDIER Transmission of severe acute respiratory syndrome in critical care : Do we need a change ? AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2004 vol. 169 pp. 1177-1178 HUGONNET STEPHANE, PITTET DIDIER Hand Hygiene among Physicians: performance, beliefs, and perceptions ANNALS OF INTERNAL MEDICINE 2004 vol. 141 pp. 1-8 PITTET DIDIER, ANNE SIMON, HUGONNET STEPHANE, PESSOA DA SILVA CARMEN, SAUVAN VALERIE, PERNEGER THOMAS A randomized clinical trial to compare fleroxacin-rifampicin with flucloxacillin or vancomycin for the treatment of staphylococcal infection CLINICAL INFECTIOUS DISEASES 2004 vol. 39(9) pp. 1285-1292 SCHRENZEL JACQUES, HARBARTH STEPHAN, SCHOCKMEL G, GENNE DANIEL, BREGENZER T, FLUECKIGER U, PETIGNAT C, JACOBS F, FRANCIOLI P, ZIMMERLI W, LEW DANIEL Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends 1991-2000 CLINICAL INFECTIOUS DISEASES 2004 vol. 38 pp. 311-320 MARCHETTI O, BILLE J, FLUCKIGER U, EGGIMANN PHILIPPE, RUEF C, GARBINO JORGE, CALANDRA T, GLAUSER MP, TÄUBER M, PITTET DIDIER Quantifying Uncertainty: Physicians' Estimates of Infection in Critically Ill Neonates and Children CLINICAL INFECTIOUS DISEASES 2004 vol. 38 pp. 1383-1390 FISCHER JE, HARBARTH STEPHAN, AGTHE AG, BENN A, RINGER SA, GOLDMANN DA, FANCONI S G-CSF and Il-8 for early diagnosis of sepsis in neotates and critically ill children - safety and cost effectiveness of a new laboratory prediction model: study protocol of a randomized controlled tri al [ISRCTN91123847] CRITICAL CARE 2004 vol. 8 pp. 443-450 HORISBERGER T, HARBARTH STEPHAN, NADAL D, BAENZIGER O, FISCHER JE Adrenal insufficiency: the link between low apolipoprotein A-I levels and poor outcome in the critically ill? CRITICAL CARE MEDICINE 2004 vol. 32 pp. 1978-1979 CHENAUD CATHERINE, MERLANI PAOLO, ROUX-LOMBARD-LATUNE PASCALE, BURGER DANIELLE, HARBARTH STEPHAN, LUYASU SAMUEL, GRAF JEAN-DANIEL, DAYER JEAN-MICHEL, RICOU BARA Low apolipoprotein A-I level at intensive care unit admission and systemic inflammatory response syndrome exacerbation CRITICAL CARE MEDICINE 2004 vol. 32 pp. 632-637 CHENAUD C, MERLANI P, ROUX LOMBARD P, BURGER D, HARBARTH S, LUYASU S, GRAF JD, DAYER JM, RICOU B Nursing resources: a major determinant of nosocomial infection ? CURRENT OPINION IN INFECTIOUS DISEASES 2004 vol. 17 pp. 329-333 HUGONNET STEPHANE, HARBARTH STEPHAN, SAX HUGO, DUNCAN R, PITTET DIDIER Antibiotic Selection Pressure and Resistance in Streptococcus pneumoniae and Streptococcus pyogenes EMERGING INFECTIOUS DISEASES (PRINT) 2004 vol. 10 pp. 514-517 ALBRICH WC, MONNET DL, HARBARTH STEPHAN Nosocomial bloodstream infection and clinical sepsis EMERGING INFECTIOUS DISEASES (PRINT) 2004 vol. 10 pp. 76-81 HUGONNET STEPHANE, SAX HUGO, EGGIMANN PHILIPPE, CHEVROLET JEAN-CLAUDE, PITTET DIDIER Are there patients with Peritonitis Who Require Empiric Therapy for Enterococcus EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 2004 vol. 23 pp. 73-77 HARBARTH STEPHAN, UCKAY I An outbreak of Pseudomonas Aeruginosa Pneumonia and Bloodstream Infection Associated With Intermittent Otitis Externa in a Healthcar Worker INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2004 vol. 25 pp. 1083-1089 ZAWACKI A, O'ROURKE E, POTTER-BYNOE G, MACONE A, HARBARTH STEPHAN, GOLDMANN D Dynamics of bacterial hand contamination during routine neonatal care INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2004 vol. 25 pp. 192-197 PESSOA DA SILVA CARMEN, DHARAN SASI, HUGONNET STEPHANE, TOUVENEAU S, POSFAY-BARBE KLARA, PFISTER RICCARDO, PITTET DIDIER Impact of ventilator -associated pneumonia on resource utilization and patient outcome INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2004 vol. pp. 1090-1096 HUGONNET STEPHANE, EGGIMANN PHILIPPE, BORST FRANCOIS, PATRICE MARICOT, CHEVROLET JEAN-CLAUDE, PITTET DIDIER Reply to letter by Tulleken et al. INTENSIVE CARE MEDICINE 2004 vol. 30 pp. 998-999 EGGIMANN PHILIPPE, HUGONNET STEPHANE, SAX HUGO, CHEVROLET JEAN-CLAUDE, PITTET DIDIER Semmelweis' legacy: insights from an international survey among 265,000 students in 32 countries INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 2004 vol. 207 pp. 1-5 HARBARTH STEPHAN, ALBRICH W, PITTET DIDIER Semmelweis' legacy: insights from an international survey among 265,000 students in 32 countries INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 2004 vol. 207(5) pp. 481-485 HARBARTH S, ALBRICH W, PITTET D A novel multiplex real-time PCR assay for rapid typing of major staphylococcal cassette chromosome mec elements JOURNAL OF CLINICAL MICROBIOLOGY 2004 vol. 42 pp. 3309-3312 FRANCOIS PATRICE, RENZI GESUELE, PITTET DIDIER, BENTO MANUELA, LEW DANIEL, HARBARTH STEPHAN, VAUDAUX PIERRE, SCHRENZEL JACQUES The Lowbury lecture: behaviour in infection control JOURNAL OF HOSPITAL INFECTION 2004 vol. 58 pp. 1-13 PITTET DIDIER Is anti-tumor necrosis factor therapy associated with increased mortality in patients with severe sepsis caused by pneumonia ? JOURNAL OF INFECTIOUS DISEASES 2004 vol. 189 pp. 1743-1743 HARBARTH S, GARBINO J, PITTET D, PUGIN J Is anti-tumor necrosis factor therapy associated with increased mortality in patients with severe sepsis caused by pneumonia? JOURNAL OF INFECTIOUS DISEASES 2004 vol. pp. 1743-1743 HARBARTH STEPHAN, GARBINO JORGE, PITTET DIDIER, PUGIN JEROME Comparative analysis and validation of different assays for glycopeptide susceptibility among methicillin-resistant staphylococcus aureus strains JOURNAL OF MICROBIOLOGICAL METHODS 2004 vol. 57 pp. 231-239 BERNARD L, VAUDAUX P, ROHNER P, HUGGLER E, ARMANET M, PITTET D, LEW DP, SCHRENZEL J Effect of a comprehensive, multidisciplinary, educational program on the use of antibiotics in a Geriatric University Hospital JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 2004 vol. 52 pp. 112-116 LUTTERS M, HARBARTH STEPHAN, JANSSENS JEAN-PAUL, FREUDIGER H, HERRMANN FRANCOIS, MICHEL JEAN-PIERRE, VOGT NICOLE Clean hands reduce the burden of disease LANCET 2004 vol. 366 pp. 185-187 PITTET DIDIER Catheter-related infections MICROBES AND INFECTION : A JOURNAL ON INFECTIOUS AGENTS AND HOST DEFENSES 2004 vol. 6 pp. 1033-1042 EGGIMANN PHILIPPE, SAX HUGO, PITTET DIDIER Enjeux, stratégie de traitement et évolution clinique des bactérémies à SARM PRESSE MEDICALE (DES 1983) 2004 vol. 12 pp. 10-17 PITTET DIDIER Risk factors for persistent carriage of methicillin resistant Staphylococcus aureus CLINICAL INFECTIOUS DISEASES. 2000 vol. 31(6) pp. 1380-1385 HARBARTH S, LIASSINE N, DHARAN S, HERRAULT P, AUCKENTHALER R, PITTET D Randomized, placebo-controlled, double-blind trial to evaluate the efficacy of mupirocin for eradicating carriage of methicillin-resistant Staphylococcus aureus ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 1999 vol. 43(6) pp. 1412-1416 HARBARTH S, DHARAN S, LIASSINE N, COPIN P, AUCKENTHALER R, PITTET D Impact of methicillin resistance on the outcome of patients with bacteremia caused by Staphylococcus aureus ARCHIVES OF INTERNAL MEDICINE 1998 vol. 158 pp. 182-189 HARBARTH STEPHAN, RUTSCHMANN OLIVIER, SUDRE PHILIPPE, PITTET DIDIER Research's domains |