|
|
|||||||
|
|
|
|
|
|
|
|
|
|||||||
|
BASE DE DONNÉES-RECHERCHE | |
GROUPE DE RECHERCHE CLINIQUE ORIENTEE PATIENTS | ||||
|
|||||||
|
Th. BERNEY et D. BOSCO | CV du Chef de Groupe | Sujet de Recherche | Composition du Groupe | |||
|
|
|
|
|
Coordonnées du groupe
Pr. Thierry BERNEY CMU Lab Transplantation Cellulaire 1 Rue Michel-Servet 1211 Genève 4 Suisse Thierry.Berney@hcuge.ch Tél.: +41 22 372 34 04 Fax: 022/372.76.89 Commentaires Pages générées le 17.11.2015 |
Sujet de recherche
|
Publications du groupe
|
Domaines de recherche
La transplantation d'îlots de Langerhans
La transplantation d'îlots de Langerhans apparaît comme une méthode valide pour le traitement du diabète de type 1. La publication en 2000 des résultats du « protocole d'Edmonton » ont montré qu'il
était possible d'atteindre chez les patients transplantés des chances d'insulino-indépendance de 80% à 1 an, grâce à un régime immunosuppresseur sans stéroïdes épargnant les îlots et à une masse
d'îlots implantée accrue par l'utilisation de 2 à 4 donneurs par receveur. Cependant de nombreuses questions demeurent et de nombreux points doivent être améliorés et constituent les thèmes de recherche
fondamentale et clinique du groupe.
1. L'implantation des greffons d'îlots est suboptimale (comme l'indique la nécessité de recourir à plusieurs donneurs), en raison principalement de stimuli pro-apoptotiques et pro-inflammatoires subis lors de l'isolement des îlots et au site d'implantation. Notre groupe développe un modèle d'interaction cellulaire entre les cellules bêta et les macrophages afin d'étudier et de contrecarrer ce phénomène. De plus, le rôle des protéines pro-inflammatoire MIF et anti-inflammatoire IL-1Ra est étudié dans des modèles de transplantation d'îlots sur des souris knock-out et transgéniques. Finalement, le rôle joué dans l'apoptose et/ou la destruction des cellules bêta par l'alpha-1-antitrypsine et les cadherines est étudié sur des modèles de rongeurs et sur des îlots humains in vitro. 2. La durée de fonction à long terme des greffons d'îlots doit être améliorée, car l'insulino-indépendance à 5 ans tombe à 15% avec le « protocole d'Edmonton ». Les causes de cette perte progressive de fonction sont inconnues et probablement multifactorielles. Des méthodes de monitoring de la masse et de la fonction des îlots greffés sont des outils nécessaires pour mieux étudier ces phénomènes. Le groupe développe des techniques d'imagerie des greffons d'îlots (PET-scanning, IRM), sur des modèles de transplantation d'îlots chez le rat, sur des îlots humains in vitro, et dans des protocoles cliniques. Le monitoring moléculaire (mesure des taux circulants du mRNA de l'insuline comme marqueurs de dégâts des cellules bêta) des greffons d'îlots est également développé en collaboration avec le groupe du Prof. J. Philippe. 3. Le régime immunosuppresseur utilisé couramment présente de nombreux désavantages en termes d'effets secondaires et notamment de néphrotoxicité. De nouveaux protocoles cliniques d'immunosuppression sans inhibiteurs de la calcineurine sont développés en collaboration avec les centres universitaires français participant au réseau franco-suisse GRAGIL (Grenoble, Lyon, Strasbourg, Besançon, Montpellier) et avec d'autres universités Européennes (Milan, Giessen, Uppsala, Bruxelles). La possibilité d'induction d¿une tolérance immunologique par blocade des signaux de co-stimulation des lymphocytes T (CD154, TRANCE) est étudiée sur des modèles murins de transplantation d'îlots. Publications du groupe Immune monitoring of pancreatic islet graft: towards a better understanding, detection and treatment of harmful events. EXPERT OPINION ON BIOLOGICAL THERAPY 2011 vol. 11(1) pp. 55-66 LACOTTE S, BERNEY T, SHAPIRO AJ, TOSO C Combined pancreatic islet-lung transplantation: a novel approach to the treatment of end-stage cystic fibrosis. AMERICAN JOURNAL OF TRANSPLANTATION 2010 vol. 10(7) pp. 1707-17012 KESSLER L AND AL. Unique arrangement of alpha- and beta-cells in human islets of Langerhans. DIABETES 2010 vol. 59(5) pp. 1202-1210 BOSCO D, ARMANET M, MOREL P, NICLAUSS N, SGROI A, MULLER Y, GIOVANNONI L, PARNAUD G, BERNEY T Non-anesthesiologist administration of propofol for GI endoscopy. ENDOSCOPY 2010 vol. 42(11) pp. 960-974 DUMONCEAU JM. AND AL. Glucose inhibits angiogenesis of isolated human pancreatic islets. JOURNAL OF MOLECULAR ENDOCRINOLOGY 2010 vol. 45(2) pp. 99-105 DUBOIS S, MADEC AM, MESNIER A, ARMANET M, CHIKH K, BERNEY T, THIVOLET CH A map of open chromatin in human pancreatic islets. NATURE GENETICS 2010 vol. 42(3) pp. 255-259 GAULTON KJ AND AL. Type 2 diabetes susceptibility gene expression in normal or diabetic sorted human alpha and beta cells: correlations with age or BMI of islet donors. PLOS ONE 2010 vol. 5(6) pp. 11053-11053 KIRKPATRICK C, MARCHETTI P, PURRELLO F, PIRO S, BUGLIANI M, BOSCO D, DE KONING EJ, ENGELSE MA, KERR-CONTE J, PATTOU F, WOLLHEIM CB Liraglutide in islet transplantation: from bench to bedside. TRANSPLANT INTERNATIONAL 2010 vol. 23(3) pp. 257-258 BERNEY T Donor pancreata: evolving approaches to organ allocation for whole pancreas versus islet transplantation. TRANSPLANTATION 2010 vol. 90(3) pp. 328-343 BERNEY T, JOHNSON PR Combined pancreatic islets-lung transplantation in cystic fibrosis-related diabetes: case reports. TRANSPLANTATION PROCEEDINGS 2010 vol. 42(10) pp. 4338-4340 KESSLER L, GREGET M, METIVIER AC, MOREAU F, ARMANET M, SANTELMO N, MASSARD G, BERNEY T, KESSLER R Evidence for Humoral Rejection of a Pancreatic Islet Graft and Rescue with Rituximab and IV Immunoglobulin Therapy AMERICAN JOURNAL OF TRANSPLANTATION 2009 vol. 9 pp. 1961-1966 KESSLER L AND AL. Long-term insulin-independence after allogeneic islet transplantation for type 1 diabetes: over the 10-year mark. AMERICAN JOURNAL OF TRANSPLANTATION 2009 vol. 9(2) pp. 419-423 BERNEY T, FERRARI-LACRAZ SYLVIE, BUEHLER LH, OBERHOLZER J, MARANGON NICOLA, PHILIPPE J, VILLARD J, MOREL P Quality of life after islet transplantation: data from the GRAGIL 1 and 2 trials. DIABETIC MEDICINE 2009 vol. 26(6) pp. 617-621 BENHAMOU PY AND AL. Low- and High-Density Lipoproteins Modulate Function Apoptosis and Proliferation of Primary Human and Murine Pancreatic beta-Cells ENDOCRINOLOGY 2009 vol. 150 pp. 4521-4530 RUTTI S, EHSES JA, SIBLER RA, PRAZAK R, ROHRER L, GEORGOPOULOS S, MEIER DT, NICLAUSS N, BERNEY T, DONATH M, VON ECKARDSTEIN A Role of the Rho-ROCK (Rho-Associated Kinase) Signaling Pathway in the Regulation of Pancreatic beta-Cell Function ENDOCRINOLOGY 2009 vol. 150 pp. 2072-2079 HAMMAR BOUVERET EVA, TOMAS A, BOSCO D, HALBAN PA Regulated laminin-332 expression in human islets of Langerhans FASEB JOURNAL 2009 vol. 23 pp. 4046-4055 ARMANET M, WOJTUSCISZYN A, MOREL P, PARNAUD G, ROUSSELLE P, SINIGAGLIA C, BERNEY T, BOSCO D Cx36 makes channels coupling human pancreatic beta-cells and correlates with insulin expression HUMAN MOLECULAR GENETICS 2009 vol. 18(3) pp. 428-439 SERRE-BEINIER V AND AL. Signaling Pathways Implicated in the Stimulation of beta-Cell Proliferation by Extracellular Matrix MOLECULAR ENDOCRINOLOGY 2009 vol. 23(8) pp. 1264-1271 PARNAUD G, HAMMAR BOUVERET EVA, RIBAUX P, DONATH M, BERNEY T, HALBAN PA Immunomodulation by blockade of the TRANCE co-stimulatory pathway in murine allogeneic islet transplantation TRANSPLANT INTERNATIONAL 2009 vol. 22(9) pp. 931-939 WOJTUSCISZYN A, ANDRES A, MOREL P, CHARVIER S, ARMANET M, TOSO C, CHOI Y, BOSCO D, BERNEY T Islet culture and counter-culture TRANSPLANT INTERNATIONAL 2009 vol. 22 pp. 531-533 BERNEY T Rapamycin in islet transplantation: friend or foe? TRANSPLANT INTERNATIONAL 2009 vol. 22(2) pp. 153-161 BERNEY T, SECCHI A Immunosuppression in pancreas transplantation: the Euro SPK trials and beyond. ACTA CHIRURGICA BELGICA 2008 vol. 108(6) pp. 673-678 MALAISE J AND AL. Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling. AMERICAN JOURNAL OF TRANSPLANTATION 2008 vol. 8(3) pp. 701-706 TOSO C, VALLEE JP, MOREL P, RIS F, DEMUYLDER-MISCHLER S, LEPETIT-COIFFE M, MARANGON NICOLA, SAUDEK F, JAMES SHAPIRO AM, BOSCO D, BERNEY T Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation. AMERICAN JOURNAL OF TRANSPLANTATION 2008 vol. 8(12) pp. 2674-2683 HADAYA K, DE RHAM C, BANDELIER C, BANDELIER CH, FERRARI-LACRAZ SYLVIE, JENDLY S, BERNEY T, BUHLER L, KAISER L, SEEBACH J, TIERCY JM, MARTIN PY, VILLARD J Organ preservation in pancreas and islet transplantation. CURRENT OPINION IN ORGAN TRANSPLANTATION 2008 vol. 13(1) pp. 59-66 BAERTSCHIGER RM, BERNEY T, MOREL P Insulin secretion from human beta cells is heterogeneous and dependent on cell-to-cell contacts. DIABETOLOGIA 2008 vol. 51(10) pp. 1843-1852 WOJTUSCISZYN A, ARMANET M, MOREL P, BERNEY T, BOSCO D Proliferation of sorted human and rat beta cells. DIABETOLOGIA 2008 vol. 51(1) pp. 91-100 PARNAUD G, BOSCO D, BERNEY T, PATTOU F, KERR-CONTE J, DONATH MY, BRUUN C, MANDRUP-POULSEN T, BILLESTRUP N, HALBAN PA The role of macrophage migration inhibitory factor on glucose metabolism and diabetes. DIABETOLOGIA 2008 vol. 51(11) pp. 1937-1946 TOSO C, EMAMAULLEE JA, MERANI S, SHAPIRO AM Glucose and leptin induce apoptosis in human beta-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases. FASEB JOURNAL 2008 vol. 22(6) pp. 1905-1913 MAEDLER K, SCHULTHESS FT, BIELMAN C, BERNEY T, BONNY C, PRENTKI M, DONATH MY, RODUIT R Beta-cell transplantation for diabetes therapy. LANCET 2008 vol. 372(9632) pp. 28-29 SECCHI A, BERNEY T, BENHAMOU PY, BRENDEL M, KORSGREN O, PIPELEERS D, PATTOU F Mesenchymal stem cells derived from human exocrine pancreas express transcription factors implicated in beta-cell development. PANCREAS 2008 vol. 37(1) pp. 75-84 BAERTSCHIGER RM, BOSCO D, MOREL P, SERRE-BEINIER V, BERNEY T, BUHLER LH, GONELLE-GISPERT C Interleukin-6 regulates pancreatic alpha-cell mass expansion. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2008 vol. 105(35) pp. 13163-13168 ELLINGSGAARD H AND AL. Combined pancreatic islet-lung transplantation with islet percutaneous portal embolization in cystic fibrosis. TRANSPLANTATION 2008 vol. 85(11) pp. 1670-1671 KESSLER L, GREGET M, METIVIER AC, MOREAU F, BOSCO D, SANTELMO N, HELMS O, PINGET M, BERNEY T, MASSARD G, KESSLER R Computer-assisted digital image analysis to quantify the mass and purity of isolated human islets before transplantation. TRANSPLANTATION 2008 vol. 86(11) pp. 1603-1609 NICLAUSS N, SGROI A, MOREL P, BAERTSCHIGER RETO, ARMANET M, WOJTUSCISZYN A, PARNAUD G, MULLER VIRGINIE, BERNEY T, BOSCO D Low risk of anti-human leukocyte antigen antibody sensitization after combined kidney and islet transplantation. TRANSPLANTATION 2008 vol. 86(2) pp. 357-359 FERRARI-LACRAZ SYLVIE, BERNEY T, MOREL P, MARANGON NICOLA, HADAYA K, DEMUYLDER-MISCHLER S, PONGRATZ G, PERNIN N, VILLARD J The role of macrophage migration inhibitory factor in mouse islet transplantation. TRANSPLANTATION 2008 vol. 86(10) pp. 1361-1369 TOSO C AND AL. 2008 Update from the Collaborative Islet Transplant Registry. TRANSPLANTATION 2008 vol. 86(12) pp. 1783-1788 ALEJANDRO R AND AL. Prospective study of 310 patients: can early CT predict the severity of acute pancreatitis? ABDOMINAL IMAGING 2007 vol. 32(1) pp. 111-115 KNOEPFLI AS, KINKEL K, BERNEY T, MOREL P, BECKER CD, POLETTI PA Invasive zygomycosis in transplant recipients CLINICAL TRANSPLANTATION 2007 vol. 21 pp. 577-582 UCKAY I, CHALANDON Y, SARTORETTI P, ROHNER P, BERNEY T, HADAYA K, VAN DELDEN C Differential expression of E-cadherin at the surface of rat beta-cells as a marker of functional heterogeneity JOURNAL OF ENDOCRINOLOGY 2007 vol. 194 pp. 21-29 BOSCO, D, ROUILLER, DG, HALBAN, PA The Fas pathway is involved in pancreatic beta cell secretory function PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2007 vol. 104 pp. 2861-2866 SCHUMANN DM, MAEDLER K, FRANKLIN I, KONRAD D, STORLING J, BONI-SCHNETZLER M, GJINOVCI A, KURRER MO, GAUTHIER BR, BOSCO D, ANDRES A, BERNEY T, GRETER M, BECHER B, CHERVONSKY AV, HALBAN PA, MANDRUP-POULSEN T, WOLLHEIM CB, DONATH MY Expectations and strategies regarding islet transplantation: Metabolic data from the GRAGIL 2 trial TRANSPLANTATION 2007 vol. 84 pp. 89-96 BADET, L, BENHAMOU, PY, WOJTUSCISZYN, A, BAERTSCHIGER, R, MILLIAT-GUITTARD, L, KESSLER, L, PENFORNIS, A, THIVOLET, C, RENARD, E, BOSCO, D, MOREL, P, MORELON, E, BAYLE, F, COLIN, C, BERNEY, T Quality of life after islet transplant: impact of the number of islet infusions and metabolic outcome TRANSPLANTATION 2007 vol. 84(5) pp. 664-666 TOSO CHRISTIAN, SHAPIRO A.M. JAMES, BOWKER SAMANTHA, DINYARI PARASTOO, PATY BREAY, RYAN EDMOND A., SENIOR PETER, JOHNSON JEFFREY Acute humoral rejection in kidney allograft following a third-party arterial transplantation AMERICAN JOURNAL OF TRANSPLANTATION 2006 vol. 6 pp. 3038-3039 FERRARI-LACRAZ S, BERNEY T, BEDNARKEWICZ M, BINET I, TIERCY JM, MARTIN PY, VILLARD J Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic control AMERICAN JOURNAL OF TRANSPLANTATION 2006 vol. 6 pp. 1704-1711 BERNEY T, MAMIN A, SHAPIRO AMJ, RITZ-LASER B, BRULHART MC, TOSO C, DEMUYLDER-MISCHLER S, ARMANET M, BAERTSCHIGER R, WOJTUSCISZYN A, BENHAMOU PY, BOSCO D, MOREL P, PHILIPPE J Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol AMERICAN JOURNAL OF TRANSPLANTATION 2006 vol. 6(5 Pt 1) pp. 1049-1058 TOSO C. ET AL. Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: Improvement of engraftment following transplantation CELL TRANSPLANTATION 2006 vol. 15 pp. 621-636 MATHE Z, DUPRAZ P, RINSCH C, THORENS B, BOSCO D, ZBINDEN M, MOREL P, BERNEY T, PEPPER MS Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1 DIABETES 2006 vol. 55(9) pp. 2455-2462 MAEDLER KATHRIN, SCHUMANN DESIREE M, SCHULTHESS FABIENNE, OBERHOLZER JOSE, BOSCO DOMENICO, BERNEY THIERRY, DONATH MARC Y. Blockade of beta 1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix DIABETES 2006 vol. 55 pp. 1413-1420 PARNAUD G, HAMMAR E, ROUILLER DG, ARMANET M, HALBAN PA, BOSCO D Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets DIABETES 2006 vol. 55(10) pp. 2713-2722 MAEDLER KATHRIN ET AL. Monitoring of the islet graft DIABETES & METABOLISM 2006 vol. 32 pp. 503-512 BERNEY T, TOSO C International trial of the Edmonton protocol for islet transplantation NEW ENGLAND JOURNAL OF MEDICINE 2006 vol. 355(13 pp. 1318-1330 SHAPIRO JAMES ET AL. Anti-HLA antibody repertoire after IVIg infusion in highly sensitised patients waiting for kidney transplantation SWISS MEDICAL WEEKLY 2006 vol. 136 pp. 696-702 FERRARI-LACRAZ S, AUBERT V, BUHLER L, PASCUAL M, ANDRESEN I, BINET I, MARTIN PY, VILLARD J Tacrolimus-associated optic neuropathy after pancreatic islet transplantation using a sirolimus/tacrolimus immunosuppressive regimen TRANSPLANTATION 2006 vol. 81(4) pp. 636-637 KESSLER LAURENCE, LUCESCU CATALINA, PINGET MICHEL, CHARTON MARIE NOELLE, MUTSCHLER VERONIQUE, WOLF PHILIPPE, BERNEY THIERRY, BENHAMOU PIERRE YVES Assessment of F-18-FDG-leucocyte imaging to monitor rejection after pancreatic islet transplantation TRANSPLANTATION PROCEEDINGS 2006 vol. 38 pp. 3033-3034 TOSO C, ZAIDI H, MOREL P, ARMANET M, WOJTUSCISZYN A, MAI G, BAERTSCHIGER R, BUHLER L, BERNEY T Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis WORLD JOURNAL OF GASTROENTEROLOGY 2006 vol. 12 pp. 915-920 DEMIRAG A, PASTOR CM, MOREL P, JEAN-CHRISTOPHE C, SIELENKAMPER AW, GUVENER N, MAI G, BERNEY T, FROSSARD JL, BUHLER LH Soluble CD40 ligand in prediction of acute severe pancreatitis WORLD JOURNAL OF GASTROENTEROLOGY 2006 vol. 12 pp. 1613-1616 FROSSARD JL, MOREL P, KWAK BR, PASTOR CM, BERNEY T, BUHLER L, VON LAUFEN A, DEMULDER S, MACH F Effect of microcapsule composition and short-term immunosuppression on intraportal biocompatibility CELL TRANSPLANTATION 2005 vol. 14 pp. 159-167 TOSO CHRISTIAN ET AL. Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells. DIABETOLOGIA 2005 vol. 48 pp. 1523-1533 BOSCO DOMENICO, MEDA PAOLO, MOREL PHILIPPE, MATTHEY-DORET DAVID, CAILLE CHOFFAT DOROTHEE, TOSO CHRISTIAN, BUHLER LEO, BERNEY THIERRY Impact of HLA matching on the outcome of simultaneous pancreas-kidney transplantation NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION 2005 vol. 20 pp. 48-53 BERNEY THIERRY, MALAISE JACQUES, MOREL PHILIPPE, TOSO CHRISTIAN, DEMUYLDER-MISCHLER S, MAJNO PIETRO, BUHLER LEO, MENTHA GILLES, EURO-SPK STUDY GROUP Impariment of renal function after islet transplant alone or islet-after-kidney transplantation using a sirolimus/tacrolimus-based immunosuppressive regimen TRANSPLANT INTERNATIONAL 2005 vol. 18 pp. 1226-1230 ANDRES ALEX ET AL. Microbial surveillance during human pancreatic islet isolation TRANSPLANT INTERNATIONAL 2005 vol. 18 pp. 584-589 BUCHER PASCAL, OBERHOLZER JOSE, BOSCO DOMENICO, MATHE ZOLTAN, TOSO CHRISTIAN, BUHLER LEO, BERNEY THIERRY, MOREL PHILIPPE Islet transplantation in a recipient presenting the factor V Leiden mutation TRANSPLANTATION 2005 vol. 79 pp. 1771-1772 ANDRES AXEL, BOSCO DOMENICO, MOREL PHILIPPE, TOSO CHRISTIAN, BAERTSCHIGER RETO, MAJNO PIETRO, BUHLER LEO, BERNEY THIERRY Logistics and transplant coordination activity in the GRAGIL Swiss-French multicenter network of islet transplantation TRANSPLANTATION 2005 vol. 79 pp. 1200-1205 KEMPF MARIE-CLAUDE ET AL. Macrophage depletion prolongs discordant but not concordant islet xenograft survival TRANSPLANTATION 2005 vol. 79 pp. 543-549 ANDRES AXEL ET AL. Positron-emission tomography imaging of early events after transplantation of islets of langerhans TRANSPLANTATION 2005 vol. 79 pp. 353-355 TOSO CHRISTIAN, ZAIDI HABIB, MOREL PHILIPPE, ARMANET MATHIEU, ANDRES AXEL, PERNIN NADINE, BAERTSCHIGER RETO, SLOSMAN DANIEL, BUHLER LEO, BOSCO DOMENICO, BERNEY THIERRY A comparison of cold storage solutions for pancreas preservation prior to islet isolation TRANSPLANTATION PROCEEDINGS 2005 vol. 37 pp. 3396-3397 WOJTUSCISZYN A. ET AL. Effect of HLA matching in simultaneous pancreas-kidney transplantation TRANSPLANTATION PROCEEDINGS 2005 vol. 37 pp. 2846-2847 MALAISE J. ET AL. Impact of a Sirolimus/Tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation TRANSPLANTATION PROCEEDINGS 2005 vol. 37 pp. 1326-1327 ANDRES A. ET AL. Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation TRANSPLANTATION PROCEEDINGS 2005 vol. 37 pp. 463-465 ANDRES A ET AL. Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors WORLD JOURNAL OF GASTROENTEROLOGY 2005 vol. 11 pp. 5691-5695 TOSO CHRISTIAN, MAJNO PIETRO, ANDRES AXEL, RUBBIA BRANDT LAURA, BERNEY THIERRY, BUHLER LEO, MOREL PHILIPPE, MENTHA GILLES Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocypes XENOTRANSPLANTATION 2005 vol. 12 pp. 457-464 MAI GANG ET AL. Treatment of hepatocellular carcinoma at the dawn of the third millenium: liver transplantation and its alternatives. ACTA GASTRO-ENTEROLOGICA BELGICA 2004 vol. 67 pp. 206-222 MAJNO P, MENTHA G, GIOSTRA E, TERRAZ S, RUBBIA-BRANDT L, BERNEY T, BUHLER L, TOSO C, HUBER O, SPAHR L, MORARD I, HADENGUE A, BECKER C, TERRIER F, MOREL P Activation of human macrophages by allogeneic islets preparations: inhibition by AOP-RANTES and heparinoids IMMUNOLOGY 2004 vol. 111 pp. 416-421 SIGRIST S, OBERHOLZER J, BOHBOT A, ESPOSITO G, MANDES K, LAMARTINE R, TOSO C, BUCHER P, PINGET M, KESSLER L Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantations TRANSPLANTATION PROCEEDINGS 2004 vol. 36 pp. 1121-1122 BERNEY T, BUCHER P, MATHE Z, ANDRES A, BOSCO D, MAGE R, TOSO C, OBERHOLZER J, BECKER C, PHILIPPE JACQUES, BUHLER L, MOREL P Microbial surveillance during human pancreatic islet isolation TRANSPLANTATION PROCEEDINGS 2004 vol. 36 pp. 1147-1148 BUCHER P, MATHE Z, BOSCO D, OBERHOLZER J, TOSO C, ANDRES A, BUHLER L, MOREL P, BERNEY T Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally TRANSPLANTATION PROCEEDINGS 2004 vol. 36 pp. 1199-1200 MATHE Z, BUCHER P, BOSCO D, ANDRES A, FUX C, TOSO C, OBERHOLZER J, WANDREY C, SAINZ-VIDAL D, ESPINOSA D, BUHLER L, MOREL P, BERNEY T Portal versus systemic drainage of small bowel allografts: comparative assessment of survival, function, rejection, and bacterial translocation JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 2002 vol. 195 pp. 804-813 BERNEY T, KATO T, NISHIDA S, TECTOR AJ, MITTAL NK, MADARIAGA J, NERY JR, CANTWELL GP, RUIZ P, TZAKIS AG Indications et résultats de la transplantation intestinale MEDECINE ET HYGIENE : JOURNAL SUISSE D'INFORMATIONS MEDICALES 2002 vol. 60 pp. 1199-1202 BERNEY T, BUHLER L, CHARBONNET P, MAJNO P, MENTHA G, MOREL P Outcome of orthotopic liver transplantation in autoimmune hepatitis according to subtypes TRANSPLANT INTERNATIONAL 2002 vol. 15 pp. 34-38 CATTAN P, BERNEY T, CONTI F, CALMUS Y, HOMBERG JC, HOUSSIN D, SOUBRANE O Successful treatment of posttransplant lymphoproliferative disease with prolonged rituximab treatment in intestinal transplant recipients TRANSPLANTATION 2002 vol. 74 pp. 1000-1006 BERNEY T, DELIS S, KATO T, NISHIDA S, MITTAL NK, MADARIAGA J, LEVI D, NERY JR, CIROCCO RE, GELMAN B, RUIZ P, TZAKIS AG Systemic versus portal venous drainage of small bowel grafts: similar long-term outcome in spite of increased bacterial translocation TRANSPLANTATION PROCEEDINGS 2002 vol. 34 pp. 961-962 BERNEY T, KATO T, NISHIDA S, MITTAL N, TECTOR AJ, LEVI D, MADARIAGA J, NERY JR, RUIZ P, TZAKIS AG Neonatal porcine pancreatic cell clusters as a potential source for transplantation in humans: characterization of proliferation, apoptosis, xenoantigen expression and gene delivery with recombinant A AV XENOTRANSPLANTATION 2002 vol. 9 pp. 14-24 VIZZARDELLI C, MOLANO RD, PILEGGI A, BERNEY T, CATTAN P, FENJVES ES, PEEL A, FRAKER C, RICORDI C, INVERARDI L Transplantation of islets of Langerhans: new developments SWISS MEDICAL WEEKLY 2001 vol. 131 pp. 671-680 BERNEY T, BUEHLER LH, CAULFIELD A, OBERHOLZER J, TOSO C, ALEJANDRO R, COOPER DK, RICORDI C, MOREL P Domaines de recherche |