A l'aide d'une approche translationnelle, notre groupe de recherche s'intéresse à l'imagerie par IRM de processus moléculaires et cellulaires. Notre spécificité repose sur le développement de stratégie d'imagerie basée sur des systèmes d'IRM clinique permettant d'examiner aussi bien de petits animaux que des patients avec les mêmes outils.

Imagerie cardiaque

Un axe de recherche de longue date concerne l'imagerie cardiaque. Nous avons développé plusieurs modèles d'occlusion / reperfusion coronaire chez le rat permettant d'imager par IRM l'effet d'une ischémie et ses conséquences. Nous avons montré qu'il était possible de mesurer la zone à risque chez le rat à l'aide de manganèse, de visualiser d'une manière non invasive la migration des monocytes sur le lieu d'un infarctus du myocarde. Après avoir validé une méthode pour mesurer la fonction et la taille d'un infarctus myocardique chez la souris, nous investiguons le potentiel de nouveaux produits de contraste à base d'oxide de fer pour l'évaluation de la réponse inflammatoire dans l'infarctus myocardique.

Arthrite : projet NanoDiaRA

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Publications du groupe

Noninvasive stress testing of myocardial perfusion defects: head-to-head comparison of thallium-201 SPECT to MRI perfusion.
JOURNAL OF NUCLEAR CARDIOLOGY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF NUCLEAR CARDIOLOGY
2009 vol. 16(4) pp. 549-561
VINCENTI G, NKOULOU R, STEINER C, IMPERIANO H, AMBROSIO G, MACH F, RATIB O, VALLEE JP, SCHINDLER TH

SNR enhancement of highly-accelerated real-time cardiac MRI acquisitions based on non-local means algorithm
MEDICAL IMAGE ANALYSIS
2009 vol. 13(4) pp. 598-608
NAEGEL B, CERNICANU A, HYACINTHE JN, TOGNOLINI M, VALLEE JP

The viability of kidneys tested by gadolinium-perfusion MRI during ex vivo perfusion
PROGRES EN UROLOGIE : JOURNAL DE L'ASSOCIATION FRANCAISE D'UROLOGIE ET DE LA SOCIETE FRANCAISE D'UROLOGIE
2009 vol. 19(5) pp. 307-312
BUCHS JB, LAZEYRAS F, BUHLER L, VALLEE JP, NASTASI A, RUTTIMANN R, MOREL P

Clinical magnetic resonance imaging of pancreatic islet grafts after iron nanoparticle labeling.
AMERICAN JOURNAL OF TRANSPLANTATION
2008 vol. 8(3) pp. 701-706
TOSO C, VALLEE JP, MOREL P, RIS F, DEMUYLDER-MISCHLER S, LEPETIT-COIFFE M, MARANGON NICOLA, SAUDEK F, JAMES SHAPIRO AM, BOSCO D, BERNEY T

Cine and tagged cardiovascular magnetic resonance imaging in normal rat at 1.5 T: a rest and stress study.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
2008 vol. 10(1) pp. 48-48
DAIRE JL, JACOB JP, HYACINTHE JN, CROISILLE P, MONTET-ABOU K, RICHTER S, BOTSIKAS D, LEPETIT-COIFFE M, MOREL D, VALLEE JP

In vivo myocardial infarct area at risk assessment in the rat using manganese enhanced magnetic resonance imaging (MEMRI) at 1.5T.
MAGNETIC RESONANCE IN MEDICINE : OFFICIAL JOURNAL OF THE SOCIETY OF MAGNETIC RESONANCE IN MEDICINE / SOCIETY OF MAGNETIC RESONANCE IN MEDICINE
2008 vol. 59(6) pp. 1422-1430
DAIRE JL, HYACINTHE JN, TATAR I, MONTET-ABOU K, IVANCEVIC MK, MASTERSON K, JORGE-COSTA M, MOREL DR, VALLEE JP

Feasibility of complementary spatial modulation of magnetization tagging in the rat heart after manganese injection.
NMR IN BIOMEDICINE
2008 vol. 21(1) pp. 15-21
HYACINTHE JN, IVANCEVIC MK, DAIRE JL, VALLEE JP

High-resolution complementary spatial modulation of magnetization (CSPAMM) rat heart tagging on a 1.5 Tesla Clinical Magnetic Resonance System: a preliminary feasibility study
INVESTIGATIVE RADIOLOGY
2007 vol. 42(3) pp. 204-210
IVANCEVIC MK, DAIRE JL, HYACINTHE JN, CRELIER G, KOZERKE S, MONTET-ABOU K, GUNES-TATAR I, MOREL DR, VALLEE JP

Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes
INVESTIGATIVE RADIOLOGY
2007 vol. 42 pp. 652-658
MONTET X, PASTOR CM, VALLEE JP, BECKER CD, GEISSBUHLER A, MOREL DR, MEDA P

Comparative evaluation of active contour model extensions for automated cardiac MR image segmentation by regional error assessment
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
2007 vol. 20 pp. 69-82
NGUYEN, D, MASTERSON, K, VALLEE, JP

Coarctation of the aorta: pre and postoperative evaluation with MRI and MR angiography; correlation with echocardiography and surgery
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
2006 vol. 22 pp. 457-475
DIDIER D, SAINT-MARTIN C, LAPIERRE C, TRINDADE PT, LAHALAIDI N, VALLEE JP, KALANGOS A, FRIEDLI B, BEGHETTI M

Analysis of contrast-enhanced MR images to assess renal function
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
2006 vol. 19 pp. 167-179
MICHOUX N, VALEE JP, PECHERE-BERTSCHI A, MONTET X, BUEHLER L, VAN BEERS BE

Optimization of cardiac cine in the rat on a clinical 1.5-T MR system
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
2006 vol. 19 pp. 144-151
MONTET-ABOU K, DAIRE JL, IVANCEVIC MK, HYACINTHE JN, NGUYEN D, JORGE-COSTA M, MOREL DR, VALLEE JP

Bone motion analysis from dynamic MRI : acquisition and tracking
ACADEMIC RADIOLOGY
2005 vol. 12 pp. 1285-1292
B. GILLES, R. PERRIN, N. MAGNENAT-THALMANN, VALLEE JEAN-PAUL

Casimage project - A digital teaching file authoring environment
JOURNAL OF THORACIC IMAGING
2004 vol. 19 pp. 103-108
ROSSET A, MULLER H, MARTINS M, DFOUNI N, VALLEE JEAN-PAUL, RATIB OSMAN

Use of high flip angle in T1-prepared FAST sequences for myocardial perfusion quantification.
EUROPEAN RADIOLOGY
2003 vol. 13 pp. 507-514
VALLEE JP, IVANCEVIC MK, LAZEYRAS F, KASUBOSKI L., CHATELAIN P, RIGHETTI A, DIDIER D

Improvement in the quantification of myocardial perfusion using an automatic spline-based registration algorithm.
JOURNAL OF MAGNETIC RESONANCE IMAGING
2003 vol. 18 pp. 160-168
IVANCEVIC M.K., THEVENAZ P., VALLEE JP

Inflow effect in first-pass cardiac and renal MRI.
JOURNAL OF MAGNETIC RESONANCE IMAGING
2003 vol. 18 pp. 372-376
IVANCEVIC M.K., ZIMINE I., FOXALL D., LOCOQ G., RIGHETTI A, DIDIER D, VALLEE JP

Quantification of myocardial perfusion by MRI after coronary occlusion
MAGNETIC RESONANCE IN MEDICINE : OFFICIAL JOURNAL OF THE SOCIETY OF MAGNETIC RESONANCE IN MEDICINE / SOCIETY OF MAGNETIC RESONANCE IN MEDICINE
1998 vol. 40 pp. 287-297
VALLEE

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Domaines de recherche

ISCHEMIE
IRM
perfusion
ANALYSE D'IMAGE
COEUR