L. BUHLER et Ph. MOREL  CV du Chef de Groupe  Composition du Groupe

  Coordonnées du groupe

Pr. L. BÜHLER
HUG/ Dpt Chirurgie
Serv. Chirurgie Viscérale
Rue Gabrielle-Perret-Gentil 4
1211 Genève 14
Suisse

Leo.Buhler@hcuge.ch

Tél.: 022/ 372 76 98
Fax: 022/ 372 76 89




Commentaires



Pages générées le 17.11.2015
Sujet de recherche | Publications du groupe | Domaines de recherche

Cultures cellulaires et transplantations

Le nombre d'organes humains disponibles pour la transplantation étant devenu très faible, d'autres sources d'organes ou de tissus doivent être trouvés. Les buts de nos projets sont :1. d'évaluer le potentiel d'hépatocytes primaires ou immortalisés, pour la transplantation et le traitement de l'insuffisance hépatique aiguë;2. d'évaluer le potentiel de cellules souches mésenchymateuses adultes, de transdifférenciation en hépatocytes, pour le traitement de l'insuffisance hépatique chronique.Notre Laboratoire a acquis une expérience dans la recherche et l'application clinique de la transplantation d'îlots de Langerhans. Nous avons également développé dans notre Laboratoire la technique de l'isolement, de l'encapsulation et de la transplantation d'hépatocytes d'animaux et humains.En collaboration avec le Laboratoire du Professeur Didier TRONO, des hépatocytes humains ont été immortalisés grâce à des vecteurs lentiviraux. Des hépatocytes de rats primaires ou des hépatocytes humains immortalisés ont été encapsulés et transplantés dans des souris avec insuffisance hépatique aiguë, induite par surdosage de paracétamol, et des hépatocytes xénogéniques ont permis une augmentation significative de la survie des animaux. Nous planifions maintenant de tester la fonction et la survie d'hépatocytes encapsulés et transplantés dans des modèles de grands animaux avec insuffisance hépatique aiguë. Nous avons établi des techniques d'isolement et de culture de cellules mésenchymateuses adultes chez la souris et l'humain. Nous allons tester des conditions nouvelles de culture cellulaire, afin de permettre une expansion et une différentiation vers la lignée hépatocytaire. Nous allons mesurer l'expression de gênes durant la différenciation des cellules mésenchymateuses vers l'hépatocytes, par RNA microarrays. Des cellules type hépatocytaire seront transplantées dans les souris Fumaryl-acetoacétate-hydrolase déficientes, afin d'étudier l'implantation et la régénération au sein d'une foie avec insuffisance hépatique chronique.D'autre part, nous étudierons la capacité d'immuno-régulation de cellules mésenchymateuses adultes, en réalisant des cultures lymphocytaires mixtes par co-cultures de cellules présentatrices d'antigènes, des cellules T, et des cellules mésenchymateuses adultes, à différents points de leur différenciation vers la cellule hépatocytaire. Finalement, nous étudierons les caractéristiques d'immuno-modulation de cellules mésenchymateuses, en réalisant des transplantations allo- et xénogéniques dans des souris immuno-déficientes et immuno-compétentes.Ces projets ont le potentiel de développer de nouvelles stratégies pour le traitement de l'insuffisance hépatique, et d'évaluer de nouvelles sources de tissus pour la transplantation.




Publications du groupe

Natural killer cell receptor--repertoire and functions after induction therapy by polyclonal rabbit anti-thymocyte globulin in unsensitized kidney transplant recipients.
CLINICAL IMMUNOLOGY
2010 vol. 137(2) pp. 250-260
HADAYA K, AVILA Y, VALLOTON L, DE RHAM C, BANDELIER C, FERRARI-LACRAZ S, PASCUAL M, PANTALEO G, MARTIN PY, BUHLER L, VILLARD J

Peroxisome proliferator-activated receptor alpha (PPARalpha) protects against oleate-induced INS-1E beta cell dysfunction by preserving carbohydrate metabolism.
DIABETOLOGIA
2010 vol. 53(2) pp. 331-340
FRIGERIO F, BRUN T, BARTLEY C, USARDI A, BOSCO D, RAVNSKJAER K, MANDRUP S, MAECHLER P

HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation.
JOURNAL OF LEUKOCYTE BIOLOGY
2010 vol. 87(2) pp. 223-235
DEL RIO ML, LUCAS CL, BUHLER LH, RAYAT G, RODRIGUEZ-BARBOSA JI

Hepatitis C virus infection after liver transplantation is associated with lower levels of activated CD4(+)CD25(+)CD45RO(+)IL-7ralpha(high) T cells.
LIVER TRANSPLANTATION : OFFICIAL PUBLICATION OF THE AMERICAN ASSOCIATION FOR THE STUDY OF LIVER DISEASES AND THE INTERNATIONAL LIVER TRANSPLANTATION SOCIETY
2010 vol. 16(1) pp. 49-55
CIUFFREDA D, CODARRI L, BUHLER L, VALLOTTON L, GIOSTRA E, MENTHA G, MOREL P, PANTALEO G, PASCUAL M

Expression of the hepatic Niemann-Pick C1 like 1 protein gene is sensitive to rosuvastatin treatment of primary human hepatocytes.
PHARMACOGENETICS AND GENOMICS
2010 vol. 20(7) pp. 455-458
BRULHART, DEAKIN S, SGROI A, BUHLER L, JAMES RW

Anti-CD154 mAb and rapamycin induce T regulatory cell mediated tolerance in rat-to-mouse islet transplantation.
PLOS ONE
2010 vol. 5(4) pp. 10352-10352
MULLER YD AND AL.

Magnetic resonance imaging as the sole radiological assessment for living donor nephrectomy.
UROLOGIA INTERNATIONALIS
2010 vol. 84(1) pp. 56-60
FLEURY N, VALLEE JP, HADAYA K, BUHLER LH, MARTIN PY, ISELIN C

Vascular invasion in pancreatic cancer: Imaging modalities, preoperative diagnosis and surgical management.
WORLD JOURNAL OF GASTROENTEROLOGY
2010 vol. 16(7) pp. 818-831
BUCHS NC, CHILCOTT M, POLETTI PA, BUHLER LH, MOREL P

Transplantation of mouse embryonic stem cells induces hematopoietic and tissue chimerism in rats.
XENOTRANSPLANTATION
2010 vol. 17(5) pp. 362-369
BAERTSCHIGER RM, GONELLE-GISPERT C, MOREL P, SGROI A, SERRE-BEINIER V, STOUFFS M, JACONI M, BUHLER LH

Long-term insulin-independence after allogeneic islet transplantation for type 1 diabetes: over the 10-year mark.
AMERICAN JOURNAL OF TRANSPLANTATION
2009 vol. 9(2) pp. 419-423
BERNEY T, FERRARI-LACRAZ SYLVIE, BUEHLER LH, OBERHOLZER J, MARANGON NICOLA, PHILIPPE J, VILLARD J, MOREL P

Renal and cardiac endothelial heterogeneity impact acute vascular rejection in pig-to-baboon xenotransplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
2009 vol. 9(5) pp. 1006-1016
KNOSALLA C AND AL.

Improved survival of fulminant liver failure by transplantation of microencapsulated cryopreserved porcine hepatocytes in mice.
CELL TRANSPLANTATION
2009 vol. 18(1) pp. 101-110
MEI J, SGROI A, MAI G, BAERTSCHIGER RM, GONELLE-GISPERT C, SERRE-BEINIER V, MOREL P, BUHLER LH

Unsaturated fatty acids inhibit the expression of tumor suppressor phosphatase and tensin homolog (PTEN) via microRNA-21 up-regulation in hepatocytes.
HEPATOLOGY
2009 vol. 49(4) pp. 1176-1184
VINCIGUERRA M, SGROI A, VEYRAT-DUREBEX C, RUBBIA-BRANDT L, BUHLER LH, FOTI M

Cx36 makes channels coupling human pancreatic beta-cells and correlates with insulin expression
HUMAN MOLECULAR GENETICS
2009 vol. 18(3) pp. 428-439
SERRE-BEINIER V AND AL.

Fibrogenic potential of human multipotent mesenchymal stromal cells in injured liver.
PLOS ONE
2009 vol. 4(8) pp. 6657-6657
BAERTSCHIGER RM, SERRE-BEINIER V, MOREL P, BOSCO D, PEYROU M, CLEMENT S, SGROI A, KAELIN A, BUHLER LH, GONELLE-GISPERT C

The viability of kidneys tested by gadolinium-perfusion MRI during ex vivo perfusion
PROGRES EN UROLOGIE : JOURNAL DE L'ASSOCIATION FRANCAISE D'UROLOGIE ET DE LA SOCIETE FRANCAISE D'UROLOGIE
2009 vol. 19(5) pp. 307-312
BUCHS JB, LAZEYRAS F, BUHLER L, VALLEE JP, NASTASI A, RUTTIMANN R, MOREL P

Immunomodulation by blockade of the TRANCE co-stimulatory pathway in murine allogeneic islet transplantation
TRANSPLANT INTERNATIONAL
2009 vol. 22(9) pp. 931-939
WOJTUSCISZYN A, ANDRES A, MOREL P, CHARVIER S, ARMANET M, TOSO C, CHOI Y, BOSCO D, BERNEY T

What clinical alternatives to whole liver transplantation? Current status of artificial devices and hepatocyte transplantation.
TRANSPLANTATION
2009 vol. 87(4) pp. 457-466
SGROI A, SERRE-BEINIER V, MOREL P, BUHLER LH

T regulatory cells in xenotransplantation.
XENOTRANSPLANTATION
2009 vol. 16(3) pp. 121-128
MULLER Y, GOLSHAYAN D, EHIRCHIOU D, WEKERLE T, SEEBACH JD, BUHLER LH

Natural killer cell receptor repertoire and their ligands, and the risk of CMV infection after kidney transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
2008 vol. 8(12) pp. 2674-2683
HADAYA K, DE RHAM C, BANDELIER C, BANDELIER CH, FERRARI-LACRAZ SYLVIE, JENDLY S, BERNEY T, BUHLER L, KAISER L, SEEBACH J, TIERCY JM, MARTIN PY, VILLARD J

Polyfunctional HCV-specific T-cell responses are associated with effective control of HCV replication.
EUROPEAN JOURNAL OF IMMUNOLOGY
2008 vol. 38(10) pp. 2665-2677
CIUFFREDA D AND AL.

Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes.
HEPATOLOGY
2008 vol. 48(3) pp. 799-807
CLEMENT S, JUGE-AUBRY CRISTIANA, SGROI A, CONZELMAN S, PAZIENZA VALERIO, PITTET-CUENOD B, MEIER CA, NEGRO F

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1.
HUMAN MOLECULAR GENETICS
2008 vol. 17(4) pp. 478-489
BRUN T, HE KH, LUPI R, BOEHM B, WOJTUSCISZYN A, SAUTER N, DONATH M, MARCHETTI P, MAEDLER K, GAUTHIER BR

Mesenchymal stem cells derived from human exocrine pancreas express transcription factors implicated in beta-cell development.
PANCREAS
2008 vol. 37(1) pp. 75-84
BAERTSCHIGER RM, BOSCO D, MOREL P, SERRE-BEINIER V, BERNEY T, BUHLER LH, GONELLE-GISPERT C

Proteomic profiling in an animal model of acute pancreatitis.
PROTEOMICS
2008 vol. 8(17) pp. 3621-3631
FETAUD V, FROSSARD JL, FARINA A, PASTOR CM, BUHLER L, DUMONCEAU JM, HADENGUE A, HOCHSTRASSER DENIS, LESCUYER P

PD-1/PD-L1, PD-1/PD-L2, and other co-inhibitory signaling pathways in transplantation.
TRANSPLANT INTERNATIONAL
2008 vol. 21(11) pp. 1015-1028
DEL RIO ML, BUHLER LH, GIBBONS C, TIAN J, RODRIGUEZ-BARBOSA JI

Computer-assisted digital image analysis to quantify the mass and purity of isolated human islets before transplantation.
TRANSPLANTATION
2008 vol. 86(11) pp. 1603-1609
NICLAUSS N, SGROI A, MOREL P, BAERTSCHIGER RETO, ARMANET M, WOJTUSCISZYN A, PARNAUD G, MULLER VIRGINIE, BERNEY T, BOSCO D

Xenotransplantation literature update January-February, 2008.
XENOTRANSPLANTATION
2008 vol. 15(3) pp. 200-204
BAERTSCHIGER RM, BUHLER L

Xenotransplantation literature update March-April, 2008.
XENOTRANSPLANTATION
2008 vol. 15(4) pp. 277-280
BAERTSCHIGER RM, BUHLER L

Xenotransplantation literature update November-December, 2007.
XENOTRANSPLANTATION
2008 vol. 15(2) pp. 145-149
BAERTSCHIGER RM, BUHLER L

Xenotransplantation literature update September-October, 2007.
XENOTRANSPLANTATION
2008 vol. 15(1) pp. 64-67
BAERTSCHIGER RM, BUHLER L

Le Vacuum Assisted Closure : utilité dans le traitement des plaies abdomino-périnéales complexes
JOURNAL DE CHIRURGIE
2007 vol. 144(3) pp. 209-213
DURMISHI Y, GERVAZ P, BÜHLER L, BUCHER P, ZUFFEREY G, AL-MAZROUEI A, MOREL PH

Expansion and tissue infiltration of an allospecific CD4(+)CD25(+)CD45RO(+)IL-7R alpha(high) cell population in solid organ transplant recipients
JOURNAL OF EXPERIMENTAL MEDICINE
2007 vol. 204 pp. 1533-1541
CODARRI, L, VALLOTTON, L, CIUFFREDA, D, VENETZ, JP, GARCIA, M, HADAYA, K, BUHLER, L, ROTMAN, S, PASCUAL, M, PANTALEO, G

Characterization of endothelial-like cells derived from human mesenchymal stem cells
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
2007 vol. 5 pp. 826-834
LIU JW, DUNOYER-GEINDRE S, SERRE-BEINIER V, MAI G, LAMBERT JF, FISH RJ, PERNOD G, BUEHLER L, BOUNAMEAUX H, KRUITHOF EKO

Microarray analyses and molecular profiling of steatosis induction in immortalized human hepatocytes
LABORATORY INVESTIGATION
2007 vol. 87 pp. 792-806
DE GOTTARDI, A, VINCIGUERRA, M, SGROI, A, MOUKIL, M, RAVIER-DALL'ANTONIA, F, PAZIENZA, V, PUGNALE, P, FOTI, M, HADENGUE, A

Renal ischaemic injuries during the use of zolmitriptan for treatment of migraines in a transplanted patient under tacrolimus therapy
NEPHROLOGY DIALYSIS TRANSPLANTATION
2007 vol. 22 pp. 3341-3343
MALACARNE S, MOLL S, HADAYA K, BUHLER L, MARTIN PY

Vascular invasion in pancreatic cancer - Evaluation of endoscopic ultrasonography, computed tomography, ultrasonography, and angiography
SWISS MEDICAL WEEKLY
2007 vol. 137 pp. 286-291
BUCHS NC, FROSSARD JL, ROSSET A, CHILCOTT M, KOUTNY-FONG P, CHASSOT G, FASEL JHD, POLETTI PA, BECKER CD, MENTHA G, BÜHLER L, MOREL P

From current immunosuppressive strategies to clinical tolerance of allografts
TRANSPLANT INTERNATIONAL
2007 vol. 20 pp. 12-24
GOLSHAYAN, D, BUHLER, L, LECHLER, RI, PASCUAL, M

Successful treatment of recurrent focal segmental glomerulosclerosis after kidney transplantation by plasmapheresis and rituximab
TRANSPLANT INTERNATIONAL
2007 vol. 20 pp. 102-105
HRISTEA, D, HADAYA, K, MARANGON, N, BUHLER, L, VILLARD, J, MOREL, P, MARTIN, PY

Blockade of the PD-1/PD-1L pathway reverses the protective effect of anti-CD40L therapy in a rat to mouse concordant islet xenotransplantation model
XENOTRANSPLANTATION
2007 vol. 14 pp. 243-248
MAI, G, DEL RIO, ML, TIAN, J, RAMIREZ, P, BUHLER, L, RODRIGUEZ-BARBOSA, JI

Xenotransplantation literature update, March-April 2007
XENOTRANSPLANTATION
2007 vol. 14 pp. 360-365
BAERTSCHIGER, RM, BUHLER, LH

Xenotransplantation literature update January-February, 2007
XENOTRANSPLANTATION
2007 vol. 14 pp. 273-277
BAERTSCHIGER, RM, BUHLER, LH

Xenotransplantation literature update May-August, 2007
XENOTRANSPLANTATION
2007 vol. 14 pp. 642-652
BAERTSCHIGER, RM, BUHLER, LH

Xenotransplantation literature update November-December 2006
XENOTRANSPLANTATION
2007 vol. 14 pp. 166-170
BAERTSCHIGER, RM, BUHLER, LH

Xenotransplantation literature update September-October 2006
XENOTRANSPLANTATION
2007 vol. 14(1) pp. 83-88
BAERTSCHIGER RM, BUHLER LH

Detection of insulin mRNA in the peripheral blood after human islet transplantion predicts deterioration of metabolic control
AMERICAN JOURNAL OF TRANSPLANTATION
2006 vol. 6 pp. 1704-1711
BERNEY T, MAMIN A, SHAPIRO AMJ, RITZ-LASER B, BRULHART MC, TOSO C, DEMUYLDER-MISCHLER S, ARMANET M, BAERTSCHIGER R, WOJTUSCISZYN A, BENHAMOU PY, BOSCO D, MOREL P, PHILIPPE J

Sequential kidney/islet transplantation: efficacy and safety assessment of a steroid-free immunosuppression protocol
AMERICAN JOURNAL OF TRANSPLANTATION
2006 vol. 6(5 Pt 1) pp. 1049-1058
TOSO C. ET AL.

Pig-to-nonhuman primate islet xenotransplantation: A review of current problems
CELL TRANSPLANTATION
2006 vol. 15 pp. 89-104
ROOD PPM, BUHLER LH, BOTTINO R, TRUCCO M, COOPER DKC

Tetracycline-regulated expression of VEGF-A in beta cells induces angiogenesis: Improvement of engraftment following transplantation
CELL TRANSPLANTATION
2006 vol. 15 pp. 621-636
MATHE Z, DUPRAZ P, RINSCH C, THORENS B, BOSCO D, ZBINDEN M, MOREL P, BERNEY T, PEPPER MS

Aging correlates with decreased beta-cell proliferative capacity and enhanced sensitivity to apoptosis: a potential role for Fas and pancreatic duodenal homeobox-1
DIABETES
2006 vol. 55(9) pp. 2455-2462
MAEDLER KATHRIN, SCHUMANN DESIREE M, SCHULTHESS FABIENNE, OBERHOLZER JOSE, BOSCO DOMENICO, BERNEY THIERRY, DONATH MARC Y.

Blockade of beta 1 integrin-laminin-5 interaction affects spreading and insulin secretion of rat beta-cells attached on extracellular matrix
DIABETES
2006 vol. 55 pp. 1413-1420
PARNAUD G, HAMMAR E, ROUILLER DG, ARMANET M, HALBAN PA, BOSCO D

Low concentration of interleukin-1beta induces FLICE-inhibitory protein-mediated beta-cell proliferation in human pancreatic islets
DIABETES
2006 vol. 55(10) pp. 2713-2722
MAEDLER KATHRIN ET AL.

An audit of surgical management of gastrointestinal stromal tumours (GIST)
EJSO
2006 vol. 32 pp. 310-314
BUCHER P, EGGER JF, GERVAZ P, RIS F, WEINTRAUB D, VILLIGER P, BUHLER LH, MOREL P

Analysis of antibiotic resistance gene expression in Pseudomonas aeruginosa by quantitative real-time-PCR
FEMS MICROBIOLOGY LETTERS
2006 vol. 254 pp. 217-225
DUMAS JL, VAN DELDEN C, PERRON K, KOHLER T

Analysis of contrast-enhanced MR images to assess renal function
MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE
2006 vol. 19 pp. 167-179
MICHOUX N, VALEE JP, PECHERE-BERTSCHI A, MONTET X, BUEHLER L, VAN BEERS BE

Anti-HLA antibody repertoire after IVIg infusion in highly sensitised patients waiting for kidney transplantation
SWISS MEDICAL WEEKLY
2006 vol. 136 pp. 696-702
FERRARI-LACRAZ S, AUBERT V, BUHLER L, PASCUAL M, ANDRESEN I, BINET I, MARTIN PY, VILLARD J

Assessment of F-18-FDG-leucocyte imaging to monitor rejection after pancreatic islet transplantation
TRANSPLANTATION PROCEEDINGS
2006 vol. 38 pp. 3033-3034
TOSO C, ZAIDI H, MOREL P, ARMANET M, WOJTUSCISZYN A, MAI G, BAERTSCHIGER R, BUHLER L, BERNEY T

Abdominal plain film in patients admitted with clinical suspicion of renal colic: Should it be replaced by low-dose computed tomography?
UROLOGY
2006 vol. 67 pp. 64-68
POLETTI PA, PLATON A, RUTSCHMANN OT, VERDUN FR, SCHMIDLIN FR, ISELIN CE, VERMEULEN B, SARASIN FOP, BUHLER LH, BECKER CD

Epidural anaesthesia restores pancreatic microcirculation and decreases the severity of acute pancreatitis
WORLD JOURNAL OF GASTROENTEROLOGY
2006 vol. 12 pp. 915-920
DEMIRAG A, PASTOR CM, MOREL P, JEAN-CHRISTOPHE C, SIELENKAMPER AW, GUVENER N, MAI G, BERNEY T, FROSSARD JL, BUHLER LH

Soluble CD40 ligand in prediction of acute severe pancreatitis
WORLD JOURNAL OF GASTROENTEROLOGY
2006 vol. 12 pp. 1613-1616
FROSSARD JL, MOREL P, KWAK BR, PASTOR CM, BERNEY T, BUHLER L, VON LAUFEN A, DEMULDER S, MACH F

International inventory of xenotransplantation practices in humans
XENOTRANSPLANTATION
2006 vol. 13 pp. 482-482
BUHLER L, SGROI A, SYKES M, NOEL L

PERV Methodology
XENOTRANSPLANTATION
2006 vol. 13(3) pp. 171-
COOPER DAVID KC, BUHLER LEO

Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocytes (vol 12, pg 457, 2005)
XENOTRANSPLANTATION
2006 vol. 13 pp. 89-89
MAI G, NGUYEN TH, MOREL P, MEI J, ANDRES A, BOSCO D, BAERTSCHIGER R, TOSO C, BERNEY T, MAJNO P, MENTHA G, TRONO D, BUHLER LH

Xenotransplantation literature update January-February, 2006
XENOTRANSPLANTATION
2006 vol. 13 pp. 272-276
BAERTSCHIGER RM, BUHLER LH

Xenotransplantation literature update July-August, 2006
XENOTRANSPLANTATION
2006 vol. 13 pp. 571-575
BAERTSCHIGER RM, BUHLER LH

Xenotransplantation literature update March-April 2006
XENOTRANSPLANTATION
2006 vol. 13 pp. 368-370
BAERTSCHIGER RM, BUHLER LH

Xenotransplantation literature update May-June 2006
XENOTRANSPLANTATION
2006 vol. 13 pp. 475-480
BAERTSCHIGER RM, BUHLER LH

Xenotransplantation literature update November-December 2005
XENOTRANSPLANTATION
2006 vol. 13 pp. 96-99
BAERTSCHIGER RM, BUHLER LH

Xenotransplantation literature update September-October, 2005
XENOTRANSPLANTATION
2006 vol. 13 pp. 86-88
BAERTSCHIGER RM, BUHLER LH

Effect of microcapsule composition and short-term immunosuppression on intraportal biocompatibility
CELL TRANSPLANTATION
2005 vol. 14 pp. 159-167
TOSO CHRISTIAN ET AL.

Expression and secretion of alpha1-proteinase inhibitor are regulated by proinflammatory cytokines in human pancreatic islet cells.
DIABETOLOGIA
2005 vol. 48 pp. 1523-1533
BOSCO DOMENICO, MEDA PAOLO, MOREL PHILIPPE, MATTHEY-DORET DAVID, CAILLE CHOFFAT DOROTHEE, TOSO CHRISTIAN, BUHLER LEO, BERNEY THIERRY

Impact of HLA matching on the outcome of simultaneous pancreas-kidney transplantation
NEPHROLOGY, DIALYSIS, TRANSPLANTATION : OFFICIAL PUBLICATION OF THE EUROPEAN DIALYSIS AND TRANSPLANT ASSOCIATION - EUROPEAN RENAL ASSOCIATION
2005 vol. 20 pp. 48-53
BERNEY THIERRY, MALAISE JACQUES, MOREL PHILIPPE, TOSO CHRISTIAN, DEMUYLDER-MISCHLER S, MAJNO PIETRO, BUHLER LEO, MENTHA GILLES, EURO-SPK STUDY GROUP

Impariment of renal function after islet transplant alone or islet-after-kidney transplantation using a sirolimus/tacrolimus-based immunosuppressive regimen
TRANSPLANT INTERNATIONAL
2005 vol. 18 pp. 1226-1230
ANDRES ALEX ET AL.

Microbial surveillance during human pancreatic islet isolation
TRANSPLANT INTERNATIONAL
2005 vol. 18 pp. 584-589
BUCHER PASCAL, OBERHOLZER JOSE, BOSCO DOMENICO, MATHE ZOLTAN, TOSO CHRISTIAN, BUHLER LEO, BERNEY THIERRY, MOREL PHILIPPE

Islet transplantation in a recipient presenting the factor V Leiden mutation
TRANSPLANTATION
2005 vol. 79 pp. 1771-1772
ANDRES AXEL, BOSCO DOMENICO, MOREL PHILIPPE, TOSO CHRISTIAN, BAERTSCHIGER RETO, MAJNO PIETRO, BUHLER LEO, BERNEY THIERRY

Macrophage depletion prolongs discordant but not concordant islet xenograft survival
TRANSPLANTATION
2005 vol. 79 pp. 543-549
ANDRES AXEL ET AL.

Positron-emission tomography imaging of early events after transplantation of islets of langerhans
TRANSPLANTATION
2005 vol. 79 pp. 353-355
TOSO CHRISTIAN, ZAIDI HABIB, MOREL PHILIPPE, ARMANET MATHIEU, ANDRES AXEL, PERNIN NADINE, BAERTSCHIGER RETO, SLOSMAN DANIEL, BUHLER LEO, BOSCO DOMENICO, BERNEY THIERRY

Effect of HLA matching in simultaneous pancreas-kidney transplantation
TRANSPLANTATION PROCEEDINGS
2005 vol. 37 pp. 2846-2847
MALAISE J. ET AL.

Impact of a Sirolimus/Tacrolimus-based immunosuppressive regimen on kidney function after islet transplantation
TRANSPLANTATION PROCEEDINGS
2005 vol. 37 pp. 1326-1327
ANDRES A. ET AL.

Phylogenetic disparity influences the predominance of direct over indirect pathway of antigen presentation in islet xenotransplantation
TRANSPLANTATION PROCEEDINGS
2005 vol. 37 pp. 463-465
ANDRES A ET AL.

Treatment of fulminant liver failure by transplantation of microencapsulated primary or immortalized xenogeneic hepatocypes
XENOTRANSPLANTATION
2005 vol. 12 pp. 457-464
MAI GANG ET AL.

Treatment of hepatocellular carcinoma at the dawn of the third millenium: liver transplantation and its alternatives.
ACTA GASTRO-ENTEROLOGICA BELGICA
2004 vol. 67 pp. 206-222
MAJNO P, MENTHA G, GIOSTRA E, TERRAZ S, RUBBIA-BRANDT L, BERNEY T, BUHLER L, TOSO C, HUBER O, SPAHR L, MORARD I, HADENGUE A, BECKER C, TERRIER F, MOREL P

Islet of Langerhans allogeneic transplantation at the University of Geneva in the steroid free era in islet after kidney and simultaneous islet-kidney transplantations
TRANSPLANTATION PROCEEDINGS
2004 vol. 36 pp. 1121-1122
BERNEY T, BUCHER P, MATHE Z, ANDRES A, BOSCO D, MAGE R, TOSO C, OBERHOLZER J, BECKER C, PHILIPPE JACQUES, BUHLER L, MOREL P

Microbial surveillance during human pancreatic islet isolation
TRANSPLANTATION PROCEEDINGS
2004 vol. 36 pp. 1147-1148
BUCHER P, MATHE Z, BOSCO D, OBERHOLZER J, TOSO C, ANDRES A, BUHLER L, MOREL P, BERNEY T

Short-term immunosuppression reduces fibrotic cellular infiltration around barium-M-alginate microbeads injected intraportally
TRANSPLANTATION PROCEEDINGS
2004 vol. 36 pp. 1199-1200
MATHE Z, BUCHER P, BOSCO D, ANDRES A, FUX C, TOSO C, OBERHOLZER J, WANDREY C, SAINZ-VIDAL D, ESPINOSA D, BUHLER L, MOREL P, BERNEY T

Cryopreservation and mycophenolate therapy are detrimental to hematopoietic progenitor cells
TRANSPLANTATION
2002 vol. 74 pp. 1159-1166
BUEHLER LH, KURILLA-MAHON B, CHANG Q, ABRAHAM S, ALWAYN IP, APPEL JZ, NEWMAN D, AWWAD M, WHITE-SCHARP ME, SACKSTEIN R, SACHS DH, COOPER DK, DOWN JD

Depletion of anti-gal, antibodies in baboons by intravenous therapy with bovine serum albumin conjugated to gal oligosaccharides
TRANSPLANTATION
2002 vol. 73 pp. 129-139
TERANISHI K, GOLLACKNER B, BUEHLER LH, KNOSALLA C, CORREA L, DOWN JD, WHITE-SCHARF ME, SACHS DH, AWWAD M, COOPER DKC

Induction of kidney allograft tolerance after transient lymphohematopoietic chimerism in patients with multiple myeloma and end-stage renal disease
TRANSPLANTATION
2002 vol. 74 pp. 1405-1409
BUEHLER LH, SPITZER TR, SYKES M, SACHS DH, DELMONICO FL, TOLKOFF-RUBIN N, SAIDMAN SL, SACKSTEIN R, MCAFEE S, DEY B, COLBY C, COSIMI AB

Adult porcine islet transplantation in baboons treated with conventional immunosuppression or a non-myeloablative regimen and CD 154 blockade
XENOTRANSPLANTATION
2002 vol. 9 pp. 3-13
BUEHLER LH, DENG S, O'NEIL J, KITAMURA H, KOULMANDA M, BALDI A, RAHIER J, ALWAYN IP, APPEL JZ, AWWAD M, SACHS DH, WEIR G, SQUIFFLET JP, COOPER DK, MOREL P

Porcine hematopoietic cell xenotransplantation in nonhuman primates is complicated by thrombotic microangiopathy
BONE MARROW TRANSPLANTATION
2001 vol. 27 pp. 1227-1236
BUHLER L, GOEPFERT C, KITAMURA H, BASKER M, GOJO S, ALWAYN IP, CHANG Q, DOWN JD, TSAI H, WISE R, SACHS DH, COOPER DKC

Pig kidney transplantation in baboons: anti-gal a 1-3gal igm alone is associated with acute humoral xenograft rejection and disseminated intravascular coagulation
TRANSPLANTATION
2001 vol. 72 pp. 1743-1752
BUHLER L, YAMADA K, KITAMURA H, ALWAYN IPJ, BASKER M, APPEL JZ, COLVIN RB, WHITE-SCHARF ME, SACHS DH, ROBSON SC, AWWAD M, COOPER DKC

Coagulation and thrombotic disorders associated with pig organ and hematopoietic cell transplantation in nonhuman primates.
TRANSPLANTATION
2000 vol. 70(9) pp. 1323-1331
BUHLER L, BASKER M, ALWAYN I.P.J., GOEPFERT C, KITAMURA H, KAWAI T, GOJO S, KOZLOWSKI T, LERINO F.L, AWWAD M, SACHS D.H, SACKSTEIN R, ROBSON S.C, COOPER D.K.C.

A nonmyeloabaltive regimen with CD40L blockade leads to humoral and cellular hyporesponsiveness to pig hematopoietic cells in baboon.
TRANSPLANTATION PROCEEDINGS
2000 vol. 32 pp. 1100-1100
BUHLER L, AWWAD M, BASKER M, GOJO S, THALL A, DOWN JD, SYKES M, ANDREWS D, SACKSTEIN R, WHITE-SCHARF ME, SACHS DH, COOPER DK


Domaines de recherche

DIABETE
REGENERATION
INSUFFISANCE HEPATIQUE
TOLERANCE IMMUNITAIRE
XENOTRANSPLANTATION