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GROUPE DE RECHERCHE CLINIQUE ORIENTEE PATIENTS | ||||
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Harbarth S/Pittet D | CV du Chef de Groupe | Sujet de Recherche | Composition du Groupe |
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Coordonnées du groupe
Pr. Pittet Didier HUG/Spécialités de Médecine Serv Mal. infec. Bat Séminaire Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Didier.Pittet@hcuge.ch Tél.: 022/372.98.44 Fax: 022/372.39.87 Commentaires Pages générées le 17.11.2015 |
Sujet de recherche
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Publications du groupe
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Domaines de recherche
MRSA
Nature du problème
Depuis plusieurs années, des infections causées par des souches de staphylocoques dorés résistants à la méthicilline (MRSA) et souvent multi-résistants ont été signalées partout dans le monde. La prévalence de l'infection varie entre 0 et 50 %; elle est plus élevée dans les hôpitaux universitaires, en Suisse comme ailleurs. Situation aux HUG MRSA est un problème aux HUG depuis le début des années 90, en proportion épidémique depuis 1993-1994. Des efforts de contrôle ont été instaurés, avec succès. Malheureusement, nous assistons depuis le milieu de l'année 1999 à une nouvelle augmentation du nombre de cas, qui prend des proportions inquiétantes depuis 2000. Cette épidémie touche tous les secteurs del'institution, à des degrés variables. L'augmentation de l'incidence est attribuée en partie à l'augmentation du réservoir épidémique de provenance extérieure aux HUG. Pourquoi ce problème nous inquiète-t-il ? Les infections à MRSA sont grevées d'un taux important de morbidité et de mortalité. Elles viennent s'ajouter aux autres infections nosocomiales; leur traitement impose le recours à des antibiotiques relativement toxiques, pourvus d'effets secondaires et nécessitant des examens complémentaires pour assurer leur bonne utilisation. Enfin, la transmission intra-hospitalière est le reflet d'un manque de qualité des soins. Prévention Les principales mesures de lutte contre la propagation de l'infection sont l'hygiène des mains, l'identification des patients colonisés ou infectés, les mesures d'isolement destinées à protéger le milieu hospitalier, les précautions lors de transferts, et la réduction du portage. Projets de recherche clinique 1) Identification du réservoir Les objectifs sont : a) recueillir des informations épidémiologiques permettant une lutte globale et une action sur tous les réservoirs de l'épidémie ; b) accélérer la prise en charge et permettre l'orientation optimale des patients porteurs dès l'admission, ainsi que la détection des cas d'entourage ; c) optimaliser l''occupation des chambres d'isolement en ne les utilisant que pour des cas confirmés. 2) Prévention des infections à MRSA aux soins intensifs et mise en place d'un test ultra-rapide Les objectifs sont : a) accélérer la prise en charge et permettre l'isolement précoce de patients colonisés; b) diminuer les taux de transmission croisée et d'infections graves à MRSA. 3) Evaluation retrospective de l'épidémie à MRSA aux HUG L'objectif principal est de mieux comprendre les facteurs qui ont favorisé l'augmentation du nombre de cas MRSA depuis 2000 avec analyse épidémiologique et moléculaire de différentes souches MRSA isolées aux HUG. Publications du groupe Religion and culture: potential undercurrents influencing hand hygiene promotion in health care. AMERICAN JOURNAL OF INFECTION CONTROL 2009 vol. 37(1) pp. 28-34 ALLEGRANZI B. AND AL. The World Health Organization hand hygiene observation method. AMERICAN JOURNAL OF INFECTION CONTROL 2009 vol. 37(10) pp. 827-834 SAX H, ALLEGRANZI B, CHRAITI MN, BOYCE J, LARSON E, PITTET D Foreign body infections due to Staphylococcus epidermidis. ANNALS OF MEDICINE 2009 vol. 41(2) pp. 109-119 UCKAY I, PITTET D, VAUDAUX P, SAX H, LEW D, WALDVOGEL FA Community-associated methicillin-resistant Staphylococcus aureus: risk factors for infection, and long-term follow-up. CLINICAL MICROBIOLOGY AND INFECTION 2009 vol. 15(6) pp. 552-559 LONGTIN Y, SUDRE P, FRANCOIS P, SCHRENZEL J, ARAMBURU C, PASTOR R, GERVAIX A, RENZI G, PITTET D, HARBARTH S Impact of a prevention strategy targeting hand hygiene and catheter care on the incidence of catheter-related bloodstream infections. CRITICAL CARE MEDICINE 2009 vol. 37(7) pp. 2167-2173 ZINGG W, IMHOF A, MAGGIORINI M, STOKER R, KELLER E, RUEF C Cockroaches (Ectobius vittiventris) in an intensive care unit, Switzerland. EMERGING INFECTIOUS DISEASES (PRINT) 2009 vol. 15(3) pp. 496-497 UCKAY I, SAX H, LONGET-DI PIETRO S, BAUR H, BOULC'H MF, AKAKPO C, CHEVROLET JC, PITTET D Effect of ritonavir on the pharmacokinetics of the benzimidazoles albendazole and mebendazole: an interaction study in healthy volunteers. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 2009 vol. 65(10) pp. 999-1006 CORTI N, HECK A, RENTSCH K, ZINGG W, STIEGER B, PAULI-MAGNUS C Nurses and physicians' perceptions of the importance and impact of healthcare-associated infections and hand hygiene: a multi-center exploratory study in Hong Kong. INFECTION 2009 vol. 37(4) pp. 320-333 TAI JWM, MOK ESB, CHING PTY, SETO WH, PITTET D Evaluation of patients' mask use after the implementation of cough etiquette in the emergency department. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2009 vol. 30(9) pp. 904-908 LONGTIN Y, AKAKPO C, RUTSCHMANN O, PITTET D, SAX H Patients' beliefs and perceptions of their participation to increase healthcare worker compliance with hand hygiene. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2009 vol. 30(9) pp. 830-839 LONGTIN Y, SAX H, ALLEGRANZI B, HUGONNET S, PITTET D The World Health Organization Guidelines on Hand Hygiene in Health Care and their consensus recommendations. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2009 vol. 30(7) pp. 611-622 PITTET D. AND AL. Defining, treating and preventing hospital acquired pneumonia: European perspective. INTENSIVE CARE MEDICINE 2009 vol. 35(1) pp. 9-29 TORRES A. AND AL. Peripheral venous catheters: an under-evaluated problem. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS 2009 vol. 34 pp. 38-42 ZINGG W, PITTET D Pluripotent stem cells as new drugs? The example of Parkinson's disease INTERNATIONAL JOURNAL OF PHARMACEUTICS 2009 vol. 381(2) pp. 113-121 PREYNAT-SEAUVE O, BURKHARD PR, VILLARD J, ZINGG W, GINOVART N, FEKI A, DUBOIS-DAUPHIN M, HURST S, MAURON A, JACONI M, KRAUSE KH Preventing catheter-related bloodstream infections: thinking outside the checklist. JAMA 2009 vol. 301(12) pp. 1285-1287 PERENCEVICH EN, PITTET D Comparison of national and subnational guidelines for hand hygiene. JOURNAL OF HOSPITAL INFECTION 2009 vol. 72(3) pp. 202-210 COOKSON B, MATHAI E, ALLEGRANZI B, PESSOA-SILVA CL, BAGHERI NEJAD S, SCHNEIDER A, TSCHOPP C, WENDT C, PITTET D Hospital-wide surveillance of catheter-related bloodstream infection: from the expected to the unexpected. JOURNAL OF HOSPITAL INFECTION 2009 vol. 73(1) pp. 41-46 ZINGG W, SAX H, INAN C, CARTIER V, DIBY M, CLERGUE F, PITTET D, WALDER B Methods to evaluate the microbicidal activities of hand-rub and hand-wash agents. JOURNAL OF HOSPITAL INFECTION 2009 vol. 73(3) pp. 191-199 ROTTER M, SATTAR SA, DHARAN S, ALLEGRANZI B, MATHAI E, PITTET D Role of hand hygiene in healthcare-associated infection prevention. JOURNAL OF HOSPITAL INFECTION 2009 vol. 73(4) pp. 305-315 ALLEGRANZI B, PITTET D Surveillance of extended-spectrum-beta-lactamase-producing Enterobacteriaceae in a Swiss Tertiary Care Hospital. SWISS MEDICAL WEEKLY 2009 vol. 139(51-52) pp. 747-751 FANKHAUSER C, ZINGG W, FRANCOIS P, DHARAN S, SCHRENZEL J, PITTET D, HARBARTH S Rapid colonization with methicillin-resistant coagulase-negative staphylococci after surgery. WORLD JOURNAL OF SURGERY 2009 vol. 33(10) pp. 2058-2062 ZINGG W, IMHOF A, SENN G, DEMARTINES N, RUEF C Re: help or hindrance? Is current infection control advice applicable in low- and middle-income countries? A review of the literature. AMERICAN JOURNAL OF INFECTION CONTROL 2008 vol. 36(7) pp. 499-501 STORR J, PITTET D Novel microarray design strategy to study complex bacterial communities. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2008 vol. 74(6) pp. 1876-1885 HUYGHE ANTOINE, FRANCOIS P, CHARBONNIER YVAN, BENTO M, BONETTI EJ, PASTER BJ, BOLIVAR I, BARATTI-MAYER D, PITTET D, SCHRENZEL J Ventilator-associated pneumonia as a quality indicator for patient safety? CLINICAL INFECTIOUS DISEASES 2008 vol. 46(4) pp. 557-563 UCKAY ILKER, AHMED QA, SAX H, PITTET D Healthcare-associated infections: think globally, act locally. CLINICAL MICROBIOLOGY AND INFECTION 2008 vol. 14(10) pp. 895-907 MARCEL JP AND AL. Healthcare-associated infections in neonates. CURRENT OPINION IN INFECTIOUS DISEASES 2008 vol. 21(3) pp. 228-234 ZINGG W, POSFAY-BARBE KLARA, PITTET D Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993-2005. EMERGING INFECTIOUS DISEASES (PRINT) 2008 vol. 14(2) pp. 304-307 FRANCOIS P, HARBARTH S, HUYGHE ANTOINE, RENZI G, BENTO M, GERVAIX A, PITTET D, SCHRENZEL J Commentary: hand hygiene: it's all about when and how. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 2008 vol. 29(10) pp. 957-959 PITTET D Trial of alcohol-based hand gel in critical care units. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 2008 vol. 29(6) pp. 577-579 MERMEL LA, BOYCE JM, VOSS A, ALLEGRANZI B, PITTET D Effect of screening for methicillin-resistant Staphylococcus aureus carriage by polymerase chain reaction on the duration of unnecessary preemptive contact isolation. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2008 vol. 29(11) pp. 1077-1079 UCKAY ILKER, SAX H, ITEN A, CAMUS V, RENZI G, SCHRENZEL J, PERRIER A, PITTET D Risk factors for methicillin-resistant Staphylococcus aureus surgical site infection. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2008 vol. 29(9) pp. 890-893 HARBARTH S, HUTTNER B, GERVAZ P, FANKHAUSER C, CHRAITI MARIE-NOELLE, SCHRENZEL J, LICKER M, PITTET D Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA 2008 vol. 299(10) pp. 1149-1157 HARBARTH S, FANKHAUSER C, SCHRENZEL J, CHRISTENSON JAN, GERVAZ P, BANDIERA-CLERC C, RENZI G, VERNAZ N, SAX H, PITTET D Antibiotic prophylaxis before invasive dental procedures in patients with arthroplasties of the hip and knee. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME 2008 vol. 90(7) pp. 833-838 UCKAY ILKER, PITTET D, BERNARD L, LEW D, PERRIER A, PETER R Infection control as a major World Health Organization priority for developing countries. JOURNAL OF HOSPITAL INFECTION 2008 vol. ;68(4) pp. 285-292 PITTET D, ALLEGRANZI B, STORR J, BAGHERI NEJAD S, DZIEKAN G, LEOTSAKOS A, DONALDSON L Multi-resistant infections in repatriated patients after natural disasters: lessons learned from the 2004 tsunami for hospital infection control. JOURNAL OF HOSPITAL INFECTION 2008 vol. 68(1) pp. 1-8 UCKAY ILKER, SAX H, HARBARTH S, BERNARD L, PITTET D Rapid and high-throughput genotyping of Staphylococcus epidermidis isolates by automated multilocus variable-number of tandem repeats: a tool for real-time epidemiology. JOURNAL OF MICROBIOLOGICAL METHODS 2008 vol. 72(3) pp. 296-305 FRANCOIS P, HOCHMANN A, HUYGHE ANTOINE, BONETTI EJ, RENZI G, HARBARTH S, KLINGENBERG C, PITTET D, SCHRENZEL J A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 2008 vol. 207(5) pp. 683-689 HARBARTH S, SAX H, UCKAY I, FANKHAUSER C, AGOSTINHO A, CHRISTENSON JT, RENZI G, SCHRENZEL J, PITTET D Preventing infections acquired during health-care delivery. LANCET 2008 vol. 372(9651) pp. 1719-1720 PITTET D, ALLEGRANZI B Alcohol-based rubs for hand antisepsis. LANCET INFECTIOUS DISEASES 2008 vol. 8(10) pp. 585-586 PITTET D, DHARAN S Infection control in paediatrics. LANCET INFECTIOUS DISEASES 2008 vol. ;8(1) pp. 19-31 POSFAY-BARBE, ZERR DM, PITTET D Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study. SPINE 2008 vol. 33(18) pp. 1919-1924 PETIGNAT C AND AL. Comment on: Control of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae using a computer-assisted management program to restrict third-generation cephalosporin use. THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2008 vol. 62(5) pp. 1165-1165 HUTTNER B, PITTET D, HARBARTH S Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile. THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2008 vol. 62(3) pp. 601-607 VERNAZ N, SAX H, PITTET D, BONNABRY P, SCHRENZEL J, HARBARTH S Age limit does not replace serologic testing for determination of immune status for measles INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 2007 vol. 28 pp. 1117-1120 UCKAY I, HUGONNET S, KAISER L, SAX HG, PITTET D Determinants of good adherence to hand hygiene among healthcare workers who have extensive exposure to hand hygiene campaigns INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2007 vol. 28(11) pp. 1267-1274 SAX H, UÇKAY I, RICHET H, ALLEGRANZI B, PITTET D Double-blind, randomized, crossover trial of 3 hand rub formulations: fast-track evaluation of tolerability and acceptability INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2007 vol. 28(12) pp. 1344-1351 PITTET D, ALLEGRANZI B, SAX H, CHRAITI MN, GRIFFITHS W, RICHET H, WORLD HEALT ORG. Evaluation of three molecular assays for rapid identification of methicillin-resistant Staphylococcus aureus JOURNAL OF CLINICAL MICROBIOLOGY 2007 vol. 45 pp. 2011-2013 FRANCOIS P, BENTO M, RENZI G, HARBARTH S, PITTET D, SCHRENZEL J Behavioural considerations for hand hygiene practices: the basic building blocks JOURNAL OF HOSPITAL INFECTION 2007 vol. 65 pp. 1-8 WHITBY, M, PESSOA-SILVA, CL, MCLAWS, M, ALLEGRANZI, B, SAX, H, LARSON, E, SETO, WH, DONALDSON, L, PITTET, D My five moments for hand hygiene': a user-centred design approach to understand, train, monitor and report hand hygiene JOURNAL OF HOSPITAL INFECTION 2007 vol. 67 pp. 9-21 SAX H, ALLEGRANZI B, UCKAY I, LARSON E, BOYCE J, PITTET D Skin reactions related to hand hygiene and selection of hand hygiene products AMERICAN JOURNAL OF INFECTION CONTROL 2006 vol. 34 pp. 627-635 LARSON E, GIRARD R, PESSOA-SILVA CL, BOYCE J, DONALDSON L, PITTET D Evaluating the probability of previously unknown carriage of MRSA at hospital admission AMERICAN JOURNAL OF MEDICINE 2006 vol. 119(3) pp. 275-275 HARBARTH S, SAX H, FANKHAUSER-RODRIGUEZ C, SCHRENZEL J, AGOSTINHO A, PITTET D A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006 vol. 173 pp. 91-97 KOLLEF M, PITTET D, GARCIA MS, CHASTRE J, FAGON JY, BONTEN M, HYZY R, FLEMING TR, FUCHS H, BELLM L, MERCAT A, MANEZ R, MARTINEZ A, EGGIMANN P, DAGUERRE M, LUYT CE Procalcitonin Guidance of Antibiotic Therapy in Community-acquired Pneumonia: A Randomized Trial AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006 vol. 174(1) pp. 84-93 CHRIST-CRAIN MIRJAM ET AL. Recurrent bacteremia with Helicobacter cinaedi: case report and review of the literature BMC INFECTIOUS DISEASES 2006 vol. 6 pp. 86-86 UCKAY I, GARBINO J, DIETRICH PY, NINET B, ROHNER P, JACOMO V Reduction of urinary tract infection and antibiotic use after surgery: A controlled, prospective, befor after intervention study CLINICAL INFECTIOUS DISEASES 2006 vol. 42 pp. 1544-1551 STEPHAN F, SAX H, WACHSMUTH M, HOFFMEYER P, CLERGUE F, PITTET D Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study CRITICAL CARE 2006 vol. 10 pp. 0-0 HARBARTH S, MASUET-AUMATELL C, SCHRENZEL J, FRANCOIS P, AKAKPO C, RENZI G, PUGIN J, RICOU B, PITTET D Increased incidence of sexually transmitted infections in Geneva, Switzerland DERMATOLOGY-- 2006 vol. 212 pp. 41-46 ABRAHAM S, TOUTOUS-TRELLU L, PECHERE M, HUGONNET S, LIASSINE N, YERLY S, ROHNER P, NINET B, HIRSCHEL B, PIGUET V Primary invasive aspergillosis of the digestive tract: report of two cases and review of the literature INFECTION 2006 vol. 34(6) pp. 333-338 EGGIMANN PHILIPPE, CHEVROLET JEAN-CLAUDE, STAROBINSKI M, MAJNO PIETRO, TOTSCH MARTIN, CHAPUIS BERNARD, PITTET DIDIER Outbreak of endophthalmitis after cataract surgery: the importance of the quality of the surgical wound INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2006 vol. 27(11) pp. 1246-1248 HUGONNET STEPHANE, DOSSO ANDRE, DHARAN SASI, MARTIN YVES, HERRERO MARIA-LUISA, REGNIER CAROLE, PITTET DIDIER Challenging the world: patient safety and health care-associated infection INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE 2006 vol. 18 pp. 4-8 PITTET D, DONALDSON L Clean care is safer care': the Global Patient Safety Challenge 2005-2006 INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2006 vol. 10 pp. 419-424 PITTET D, ALLEGRANZI B, STORR J, DONALDSON L Rapid Staphylococcus aureus agr type determination by a novel multiplex real-time quantitative PCR assay JOURNAL OF CLINICAL MICROBIOLOGY 2006 vol. 44 pp. 1892-1895 FRANCOIS P, KOESSLER T, HUYGHE A, HARBARTH S, BENTO M, LEW D, ETIENNE J, PITTET D, SCHRENZEL J Recurrent osteomyelitis caused by infection with different bacterial strains without obvious source of reinfection JOURNAL OF CLINICAL MICROBIOLOGY 2006 vol. 44(3) pp. 1194-1196 UÇKAY ILKER, ASSAL MATHIEU, LEGOUT LAURENCE, ROHNER PETER, STERN RICHARD, LEW DANIEL, HOFFMEYER PIERRE, BERNARD LOUIS Use of oligoarrays for characterization of community-onset methicillin-resistant Staphylococcus aureus JOURNAL OF CLINICAL MICROBIOLOGY 2006 vol. 44 pp. 1040-1048 KOESSLER T, FRANCOIS P, CHARBONNIER Y, HUYGHE A, BENTO M, DHARAN S, RENZI G, LEW D, HARBARTH S, PITTET D, SCHRENZEL J Control of a cluster of community-associated, methicillin-resistant Staphylocloccus aureus in neonatology JOURNAL OF HOSPITAL INFECTION 2006 vol. 63 pp. 93-100 SAX H, POSFAY-BARBE K, HARBARTH S, FRANCOIS P, TOUVENEAU S, PESSOA-SILVA CL, SCHRENZEL J, DHARAN S, GERVAIX A, PITTET D Muslim health-care workers and alcohol-based handrubs LANCET 2006 vol. 367 pp. 1025-1027 AHMED QA, MEMISH ZA, ALLEGRANZI B, PITTET D Evidence-based model for hand transmission during patient care and the role of improved practices LANCET INFECTIOUS DISEASES 2006 vol. 6(10) pp. 641-652 PITTET D, ALLEGRANZI B, SAX H, DHARAN S, PESSOA-SILVA CL, DONALDSON L, BOYCE JM Postoperative fungal infections SURGICAL INFECTIONS 2006 vol. 7 Suppl 2 pp. 53-56 EGGIMANN PHILIPPE, PITTET DIDIER Treatment options of invasive fungal infections in adults SWISS MEDICAL WEEKLY 2006 vol. 136 pp. 447-463 FLUCKIGER U, MARCHETTI O, BILLE J, EGGIMANN P, ZIMMERLI S, IMHOF A, GARBINO J, RUE C, PITTET D, TAUBER M, GLAUSER M, CALANDRA T Prevalence and prediction of previously unknown MRSA carriage on admission to a geriatric hospital AGE AND AGEING 2005 vol. 34 pp. 456-462 SAX HUGO, HARBARTH STEPHAN, GAVAZZI GAETAN, HENRY NICOLE, SCHRENZEL JACQUES, ROHNER PETER, MICHEL JEAN-PIERRE, PITTET DIDIER Clean Care is safer care: the first global challenge of the WHO World Alliance for Patient Safety AMERICAN JOURNAL OF INFECTION CONTROL 2005 vol. 33 pp. 476-479 PITTET DIDIER, DONALDSON L Comparative efficacy of hand hygiene agents in the reduction of bacteria and viruses AMERICAN JOURNAL OF INFECTION CONTROL 2005 vol. 33 pp. 558-560 ROTTER M, SATTAR SA, DHARAN S, WEBBER P, VOSS A, PITTET DIDIER Infection control and quality health care in the new millenium AMERICAN JOURNAL OF INFECTION CONTROL 2005 vol. 33 pp. 258-267 PITTET DIDIER Long-term reduction of vascular access-associated bloodstream infection ANNALS OF INTERNAL MEDICINE 2005 vol. pp. 875-876 EGGIMANN PHILIPPE, HUGONNET STEPHANE, SAX HUGO, HARBARTH STEPHAN, CHEVROLET JEAN-CLAUDE, PITTET DIDIER Community-associated methicillin-resistant Staphylococcus aureus, Switzerland EMERGING INFECTIOUS DISEASES (PRINT) 2005 vol. 11 pp. 962-965 HARBARTH STEPHAN, FRANCOIS PATRICE, SCHRENZEL JACQUES, FANKHAUSER-RODRIGUEZ CAROLINA, HUGONNET STEPHANE, KOESSLER THIBAUD, HUYGHE ANTOINE, PITTET DIDIER Lack of effect of combination antibiotic therapy on mortality in patients with pneumococcal sepsis. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES 2005 vol. 24 pp. 688-690 HARBARTH STEPHAN, GARBINO JORGE, PUGIN JEROME, ROMAND JACQUES-ANDRE, PITTET DIDIER Knowledge of standard and isolation precautions in a large teaching hospital INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 2005 vol. pp. 298-304 SAX HUGO, PERNEGER THOMAS, HUGONNET STEPHANE, HERRAULT PASCALE, CHRAITI MARIE-NOELLE, PITTET DIDIER Attitudes and perceptions toward hand hygiene among healthcare workers caring for critically ill neonates INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2005 vol. 26 pp. 305-311 PESSOA DA SILVA CARMEN, POSFAY-BARBE KLARA, PFISTER RICCARDO, TOUVENEAU SYLVIE, PERNEGER THOMAS, PITTET DIDIER Clean Care is Safer Care: the first global challenge of the WHO World Alliance for Patient Safety INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2005 vol. 26 pp. 891-894 PITTET DIDIER, DONALDSON L Nosocomial bacteremia: clinical significance of a single blood culture positive for coagulase-negative staphylococci INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2005 vol. 26(8) pp. 697-702 FAVRE BERTRAND, HUGONNET STEPHANE, CORREA FELIU LILIANA, SAX HUGO, ROHNER PETER, PITTET DIDIER Invasive candidiasis: comparison of management choices by infectious disease and critical care specialists INTENSIVE CARE MEDICINE 2005 vol. 31 pp. 1514-1521 GARBINO JORGE, PITTET DIDIER Use of an automated multiple-locus, variable-number tandem repeat-based method for rapid and high-throughput genotyping of Staphylococcus aureus isolates JOURNAL OF CLINICAL MICROBIOLOGY 2005 vol. 43 pp. 3346-3355 FRANCOIS PATRICE, HUYGHE ANTOINE, CHARBONNIER YVAN, BENTO MANUELA, HERZIG SEBASTIEN, TOPOLSKI IVAN, FLEURY BENEDICTE, LEW DANIEL, VAUDAUX PIERRE, HARBARTH STEPHAN, VAN LEEUWEN WILLEM, VAN BELKUM ALEX, BLANC D.S., PITTET DIDIER, SCHRENZEL JACQUES Pasteurella multocida endophthalmitis: case report and review of the literature. KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE 2005 vol. 222(3) pp. 231-233 DANG BURGENER NP., BAGLIVO EDOARDO, HARBARTH STEPHAN, SAHABO CHRISTOPHE, PITTET DIDIER, SAFRAN AVINOAM Clean Care is Safer Care: a worldwide priority LANCET 2005 vol. 366 pp. 1246-1247 PITTET DIDIER, DONALDSON L Clean hands reduce the burden of disease LANCET 2005 vol. 366(9481) pp. 185-187 PITTET DIDIER Considerations for a WHO European strategy on health-care-associated infection, surveillance, and control LANCET INFECTIOUS DISEASES 2005 vol. 5(4) pp. 242-250 PITTET D. ET AL. Meticillin-resistant Staphylococcus aureus LANCET INFECTIOUS DISEASES 2005 vol. 5(10) pp. 653-663 BOYCE JM, COOKSON B, CHRISTIANSEN K, HORI S, VUOPIO-VARKILA J, KOCAGÖZ S, OZTOP AY, VANDENBROUCKE-GRAULS CM, HARBARTH S, PITTET D Infection and rejection in liver transplant patients: a 10-year Swiss single-centre experience SWISS MEDICAL WEEKLY 2005 vol. 135 pp. 587-593 GARBINO JORGE, ROMAND JACQUES-ANDRE, PITTET DIDIER, GIOSTRA EMILIANO, MENTHA GILLES, SUTER PETER M Considerations for a WHO European strategy on health-care-associated infection, surveillance and control THE LANCET INFECTIOUS DISEASES 2005 vol. 5 pp. 242-250 PITTET DIDIER, ALLENGRANZI B, SAX HUGO, BERTINATO L, CONCIA E, COOKSON B, FABRY J, RICHET H, PHILIP P, SPENCER RC, GANTER BW, LAZZARI S Infection in breast implants THE LANCET INFECTIOUS DISEASES 2005 vol. 5 pp. 94-106 PITTET-CUENOD BRIGITTE, MONTANDON DENYS, PITTET DIDIER Consequences of an unsufficient range of immunity in "pediatric" infectious diseases--example with measles THERAPEUTISCHE UMSCHAU : MONATSSCHRIFT FUER PRAKTISCHE MEDIZIN = REVUE THERAPEUTIQUE : REVUE MENSUELLE DE MEDECINE PRATIQUE 2005 vol. 62(10) pp. 679-684 UCKAY ILKER, SAX HUGO, HUGONNET STEPHANE, ARAMBURU C, BESSIRE N, RUTSCHMANN OLIVIER, KAISER LAURENT, GERVAIX ALAIN, SUDRE PHILIPPE, SIEGRIST CLAIRE-ANNE, PITTET DIDIER Transmission of severe acute respiratory syndrome in critical care : Do we need a change ? AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2004 vol. 169 pp. 1177-1178 HUGONNET STEPHANE, PITTET DIDIER Hand Hygiene among Physicians: performance, beliefs, and perceptions ANNALS OF INTERNAL MEDICINE 2004 vol. 141 pp. 1-8 PITTET DIDIER, ANNE SIMON, HUGONNET STEPHANE, PESSOA DA SILVA CARMEN, SAUVAN VALERIE, PERNEGER THOMAS Epidemiology of candidemia in Swiss tertiary care hospitals: secular trends 1991-2000 CLINICAL INFECTIOUS DISEASES 2004 vol. 38 pp. 311-320 MARCHETTI O, BILLE J, FLUCKIGER U, EGGIMANN PHILIPPE, RUEF C, GARBINO JORGE, CALANDRA T, GLAUSER MP, TÄUBER M, PITTET DIDIER Quantifying Uncertainty: Physicians' Estimates of Infection in Critically Ill Neonates and Children CLINICAL INFECTIOUS DISEASES 2004 vol. 38 pp. 1383-1390 FISCHER JE, HARBARTH STEPHAN, AGTHE AG, BENN A, RINGER SA, GOLDMANN DA, FANCONI S G-CSF and Il-8 for early diagnosis of sepsis in neotates and critically ill children - safety and cost effectiveness of a new laboratory prediction model: study protocol of a randomized controlled tri al [ISRCTN91123847] CRITICAL CARE 2004 vol. 8 pp. 443-450 HORISBERGER T, HARBARTH STEPHAN, NADAL D, BAENZIGER O, FISCHER JE Adrenal insufficiency: the link between low apolipoprotein A-I levels and poor outcome in the critically ill? CRITICAL CARE MEDICINE 2004 vol. 32 pp. 1978-1979 CHENAUD CATHERINE, MERLANI PAOLO, ROUX-LOMBARD-LATUNE PASCALE, BURGER DANIELLE, HARBARTH STEPHAN, LUYASU SAMUEL, GRAF JEAN-DANIEL, DAYER JEAN-MICHEL, RICOU BARA Low apolipoprotein A-I level at intensive care unit admission and systemic inflammatory response syndrome exacerbation CRITICAL CARE MEDICINE 2004 vol. 32 pp. 632-637 CHENAUD C, MERLANI P, ROUX LOMBARD P, BURGER D, HARBARTH S, LUYASU S, GRAF JD, DAYER JM, RICOU B Nursing resources: a major determinant of nosocomial infection ? CURRENT OPINION IN INFECTIOUS DISEASES 2004 vol. 17 pp. 329-333 HUGONNET STEPHANE, HARBARTH STEPHAN, SAX HUGO, DUNCAN R, PITTET DIDIER Antibiotic Selection Pressure and Resistance in Streptococcus pneumoniae and Streptococcus pyogenes EMERGING INFECTIOUS DISEASES (PRINT) 2004 vol. 10 pp. 514-517 ALBRICH WC, MONNET DL, HARBARTH STEPHAN Nosocomial bloodstream infection and clinical sepsis EMERGING INFECTIOUS DISEASES (PRINT) 2004 vol. 10 pp. 76-81 HUGONNET STEPHANE, SAX HUGO, EGGIMANN PHILIPPE, CHEVROLET JEAN-CLAUDE, PITTET DIDIER An outbreak of Pseudomonas Aeruginosa Pneumonia and Bloodstream Infection Associated With Intermittent Otitis Externa in a Healthcar Worker INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2004 vol. 25 pp. 1083-1089 ZAWACKI A, O'ROURKE E, POTTER-BYNOE G, MACONE A, HARBARTH STEPHAN, GOLDMANN D COST IMPLICATIONS OF SUCCESSFUL HAND HYGIENE PROMOTION INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2004 vol. 25 pp. 264-266 PITTET DIDIER, SAX HUGO, HUGONNET STEPHANE, HARBARTH STEPHAN Dynamics of bacterial hand contamination during routine neonatal care INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2004 vol. 25 pp. 192-197 PESSOA DA SILVA CARMEN, DHARAN SASI, HUGONNET STEPHANE, TOUVENEAU S, POSFAY-BARBE KLARA, PFISTER RICCARDO, PITTET DIDIER Impact of ventilator -associated pneumonia on resource utilization and patient outcome INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2004 vol. pp. 1090-1096 HUGONNET STEPHANE, EGGIMANN PHILIPPE, BORST FRANCOIS, PATRICE MARICOT, CHEVROLET JEAN-CLAUDE, PITTET DIDIER Reply to letter by Tulleken et al. INTENSIVE CARE MEDICINE 2004 vol. 30 pp. 998-999 EGGIMANN PHILIPPE, HUGONNET STEPHANE, SAX HUGO, CHEVROLET JEAN-CLAUDE, PITTET DIDIER Semmelweis' legacy: insights from an international survey among 265,000 students in 32 countries INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH 2004 vol. 207 pp. 1-5 HARBARTH STEPHAN, ALBRICH W, PITTET DIDIER A novel multiplex real-time PCR assay for rapid typing of major staphylococcal cassette chromosome mec elements JOURNAL OF CLINICAL MICROBIOLOGY 2004 vol. 42 pp. 3309-3312 FRANCOIS PATRICE, RENZI GESUELE, PITTET DIDIER, BENTO MANUELA, LEW DANIEL, HARBARTH STEPHAN, VAUDAUX PIERRE, SCHRENZEL JACQUES The Lowbury lecture: behaviour in infection control JOURNAL OF HOSPITAL INFECTION 2004 vol. 58 pp. 1-13 PITTET DIDIER Is anti-tumor necrosis factor therapy associated with increased mortality in patients with severe sepsis caused by pneumonia? JOURNAL OF INFECTIOUS DISEASES 2004 vol. pp. 1743-1743 HARBARTH STEPHAN, GARBINO JORGE, PITTET DIDIER, PUGIN JEROME Comparative analysis and validation of different assays for glycopeptide susceptibility among methicillin-resistant staphylococcus aureus strains JOURNAL OF MICROBIOLOGICAL METHODS 2004 vol. 57 pp. 231-239 BERNARD L, VAUDAUX P, ROHNER P, HUGGLER E, ARMANET M, PITTET D, LEW DP, SCHRENZEL J Clean hands reduce the burden of disease LANCET 2004 vol. 366 pp. 185-187 PITTET DIDIER Catheter-related infections MICROBES AND INFECTION : A JOURNAL ON INFECTIOUS AGENTS AND HOST DEFENSES 2004 vol. 6 pp. 1033-1042 EGGIMANN PHILIPPE, SAX HUGO, PITTET DIDIER Enjeux, stratégie de traitement et évolution clinique des bactérémies à SARM PRESSE MEDICALE (DES 1983) 2004 vol. 12 pp. 10-17 PITTET DIDIER Control of multiply resistant cocci: Do international comparisons help? THE LANCET INFECTIOUS DISEASES 2001 vol. 1 pp. 251-261 HARBARTH STEPHAN, ALBRICH W.C, GOLDMANN D.A, HUBNER J Risk factors for persistent carriage of methicillin resistant Staphylococcus aureus CLINICAL INFECTIOUS DISEASES. 2000 vol. 31(6) pp. 1380-1385 HARBARTH S, LIASSINE N, DHARAN S, HERRAULT P, AUCKENTHALER R, PITTET D Effect of delayed infection control measures on a hospital outbreak of MRSA JOURNAL OF HOSPITAL INFECTION 2000 vol. 46 pp. 43-49 HARBARTH STEPHAN, MARTIN PIERRE-YVES, ROHNER PETER, HENRY N, AUCKENTHALER R, PITTET DIDIER Effectiveness of a hospital wide programme to improve compliance with hand hygiene Infection Control Programme LANCET 2000 vol. 356 pp. 1307-1312 PITTET D, HUGONNET S, HARBARTH S, MOUROUGA P, SAUVAN V, TOUVENEAU S, PERNEGGER TV Impact of methicillin resistance on the outcome of patients with bacteremia caused by Staphylococcus aureus ARCHIVES OF INTERNAL MEDICINE 1998 vol. 158 pp. 182-189 HARBARTH STEPHAN, RUTSCHMANN OLIVIER, SUDRE PHILIPPE, PITTET DIDIER Domaines de recherche INFECTION NOSOCOMIALE EPIDEMIOLOGIE FACTEUR DE RISQUE HYGIENE HOSPITALIERE QUALITE DES SOINS |