Bienvenue dans la base de données-recherche

MRSA

Nature du problème
Depuis plusieurs années, des infections causées par des souches de staphylocoques dorés résistants à la méthicilline (MRSA) et souvent multi-résistants ont été signalées partout dans le monde. La prévalence de l'infection varie entre 0 et 50 %; elle est plus élevée dans les hôpitaux universitaires, en Suisse comme ailleurs.
Situation aux HUG
MRSA est un problème aux HUG depuis le début des années 90, en proportion épidémique depuis 1993-1994. Des efforts de contrôle ont été instaurés, avec succès. Malheureusement, nous assistons depuis le milieu de l'année 1999 à une nouvelle augmentation du nombre de cas, qui prend des proportions inquiétantes depuis 2000. Cette épidémie touche tous les secteurs del'institution, à des degrés variables. L'augmentation de l'incidence est attribuée en partie à l'augmentation du réservoir épidémique de provenance extérieure aux HUG.
Pourquoi ce problème nous inquiète-t-il ?
Les infections à MRSA sont grevées d'un taux important de morbidité et de mortalité. Elles viennent s'ajouter aux autres infections nosocomiales; leur traitement impose le recours à des antibiotiques relativement toxiques, pourvus d'effets secondaires et nécessitant des examens complémentaires pour assurer leur bonne utilisation. Enfin, la transmission intra-hospitalière est le reflet d'un manque de qualité des soins.
Prévention
Les principales mesures de lutte contre la propagation de l'infection sont l'hygiène des mains, l'identification des patients colonisés ou infectés, les mesures d'isolement destinées à protéger le milieu hospitalier, les précautions lors de transferts, et la réduction du portage.
Projets de recherche clinique
1) Identification du réservoir
Les objectifs sont : a) recueillir des informations épidémiologiques permettant une lutte globale et une action sur tous les réservoirs de l'épidémie ; b) accélérer la prise en charge et permettre l'orientation optimale des patients porteurs dès l'admission, ainsi que la détection des cas d'entourage ; c) optimaliser l''occupation des chambres d'isolement en ne les utilisant que pour des cas confirmés.
2) Prévention des infections à MRSA aux soins intensifs et mise en place d'un test ultra-rapide
Les objectifs sont : a) accélérer la prise en charge et permettre l'isolement précoce de patients colonisés; b) diminuer les taux de transmission croisée et d'infections graves à MRSA.
3) Evaluation retrospective de l'épidémie à MRSA aux HUG
L'objectif principal est de mieux comprendre les facteurs qui ont favorisé l'augmentation du nombre de cas MRSA depuis 2000 avec analyse épidémiologique et moléculaire de différentes souches MRSA isolées aux HUG.

Publications du groupe

Re: help or hindrance? Is current infection control advice applicable in low- and middle-income countries? A review of the literature.
AMERICAN JOURNAL OF INFECTION CONTROL
2008 vol. 36(7) pp. 499-501
STORR J, PITTET D

Novel microarray design strategy to study complex bacterial communities.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
2008 vol. 74(6) pp. 1876-1885
HUYGHE ANTOINE, FRANCOIS P, CHARBONNIER YVAN, BENTO M, BONETTI EJ, PASTER BJ, BOLIVAR I, BARATTI-MAYER D, PITTET D, SCHRENZEL J

Ventilator-associated pneumonia as a quality indicator for patient safety?
CLINICAL INFECTIOUS DISEASES
2008 vol. 46(4) pp. 557-563
UCKAY ILKER, AHMED QA, SAX H, PITTET D

Healthcare-associated infections: think globally, act locally.
CLINICAL MICROBIOLOGY AND INFECTION
2008 vol. 14(10) pp. 895-907
MARCEL JP AND AL.

Healthcare-associated infections in neonates.
CURRENT OPINION IN INFECTIOUS DISEASES
2008 vol. 21(3) pp. 228-234
ZINGG W, POSFAY-BARBE KLARA, PITTET D

Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993-2005.
EMERGING INFECTIOUS DISEASES (PRINT)
2008 vol. 14(2) pp. 304-307
FRANCOIS P, HARBARTH S, HUYGHE ANTOINE, RENZI G, BENTO M, GERVAIX A, PITTET D, SCHRENZEL J

Commentary: hand hygiene: it's all about when and how.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
2008 vol. 29(10) pp. 957-959
PITTET D

Trial of alcohol-based hand gel in critical care units.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
2008 vol. 29(6) pp. 577-579
MERMEL LA, BOYCE JM, VOSS A, ALLEGRANZI B, PITTET D

Effect of screening for methicillin-resistant Staphylococcus aureus carriage by polymerase chain reaction on the duration of unnecessary preemptive contact isolation.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA
2008 vol. 29(11) pp. 1077-1079
UCKAY ILKER, SAX H, ITEN A, CAMUS V, RENZI G, SCHRENZEL J, PERRIER A, PITTET D

Risk factors for methicillin-resistant Staphylococcus aureus surgical site infection.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA
2008 vol. 29(9) pp. 890-893
HARBARTH S, HUTTNER B, GERVAZ P, FANKHAUSER C, CHRAITI MARIE-NOELLE, SCHRENZEL J, LICKER M, PITTET D

Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients.
JAMA
2008 vol. 299(10) pp. 1149-1157
HARBARTH S, FANKHAUSER C, SCHRENZEL J, CHRISTENSON JAN, GERVAZ P, BANDIERA-CLERC C, RENZI G, VERNAZ N, SAX H, PITTET D

Antibiotic prophylaxis before invasive dental procedures in patients with arthroplasties of the hip and knee.
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME
2008 vol. 90(7) pp. 833-838
UCKAY ILKER, PITTET D, BERNARD L, LEW D, PERRIER A, PETER R

Infection control as a major World Health Organization priority for developing countries.
JOURNAL OF HOSPITAL INFECTION
2008 vol. ;68(4) pp. 285-292
PITTET D, ALLEGRANZI B, STORR J, BAGHERI NEJAD S, DZIEKAN G, LEOTSAKOS A, DONALDSON L

Multi-resistant infections in repatriated patients after natural disasters: lessons learned from the 2004 tsunami for hospital infection control.
JOURNAL OF HOSPITAL INFECTION
2008 vol. 68(1) pp. 1-8
UCKAY ILKER, SAX H, HARBARTH S, BERNARD L, PITTET D

Rapid and high-throughput genotyping of Staphylococcus epidermidis isolates by automated multilocus variable-number of tandem repeats: a tool for real-time epidemiology.
JOURNAL OF MICROBIOLOGICAL METHODS
2008 vol. 72(3) pp. 296-305
FRANCOIS P, HOCHMANN A, HUYGHE ANTOINE, BONETTI EJ, RENZI G, HARBARTH S, KLINGENBERG C, PITTET D, SCHRENZEL J

A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission.
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
2008 vol. 207(5) pp. 683-689
HARBARTH S, SAX H, UCKAY ILKER, FANKHAUSER C, AGOSTINHO A, CHRISTENSON JT, RENZI G, SCHRENZEL J, PITTET D

Preventing infections acquired during health-care delivery.
LANCET
2008 vol. 372(9651) pp. 1719-1720
PITTET D, ALLEGRANZI B

Alcohol-based rubs for hand antisepsis.
LANCET INFECTIOUS DISEASES
2008 vol. 8(10) pp. 585-586
PITTET D, DHARAN S

Infection control in paediatrics.
LANCET INFECTIOUS DISEASES
2008 vol. ;8(1) pp. 19-31
POSFAY-BARBE, ZERR DM, PITTET D

Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study.
SPINE
2008 vol. 33(18) pp. 1919-1924
PETIGNAT C AND AL.

Comment on: Control of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae using a computer-assisted management program to restrict third-generation cephalosporin use.
THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
2008 vol. 62(5) pp. 1165-1165
HUTTNER B, PITTET D, HARBARTH S

Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile.
THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
2008 vol. 62(3) pp. 601-607
VERNAZ N, SAX H, PITTET D, BONNABRY P, SCHRENZEL J, HARBARTH S

Evaluation of three molecular assays for rapid identification of methicillin-resistant Staphylococcus aureus
JOURNAL OF CLINICAL MICROBIOLOGY
2007 vol. 45 pp. 2011-2013
FRANCOIS P, BENTO M, RENZI G, HARBARTH S, PITTET D, SCHRENZEL J

Skin reactions related to hand hygiene and selection of hand hygiene products
AMERICAN JOURNAL OF INFECTION CONTROL
2006 vol. 34 pp. 627-635
LARSON E, GIRARD R, PESSOA-SILVA CL, BOYCE J, DONALDSON L, PITTET D

Evaluating the probability of previously unknown carriage of MRSA at hospital admission
AMERICAN JOURNAL OF MEDICINE
2006 vol. 119(3) pp. 275-275
HARBARTH S, SAX H, FANKHAUSER-RODRIGUEZ C, SCHRENZEL J, AGOSTINHO A, PITTET D

A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
2006 vol. 173 pp. 91-97
KOLLEF M, PITTET D, GARCIA MS, CHASTRE J, FAGON JY, BONTEN M, HYZY R, FLEMING TR, FUCHS H, BELLM L, MERCAT A, MANEZ R, MARTINEZ A, EGGIMANN P, DAGUERRE M, LUYT CE

Procalcitonin Guidance of Antibiotic Therapy in Community-acquired Pneumonia: A Randomized Trial
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
2006 vol. 174(1) pp. 84-93
CHRIST-CRAIN MIRJAM ET AL.

Recurrent bacteremia with Helicobacter cinaedi: case report and review of the literature
BMC INFECTIOUS DISEASES
2006 vol. 6 pp. 86-86
UCKAY I, GARBINO J, DIETRICH PY, NINET B, ROHNER P, JACOMO V

Reduction of urinary tract infection and antibiotic use after surgery: A controlled, prospective, befor after intervention study
CLINICAL INFECTIOUS DISEASES
2006 vol. 42 pp. 1544-1551
STEPHAN F, SAX H, WACHSMUTH M, HOFFMEYER P, CLERGUE F, PITTET D

Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study
CRITICAL CARE
2006 vol. 10 pp. 0-0
HARBARTH S, MASUET-AUMATELL C, SCHRENZEL J, FRANCOIS P, AKAKPO C, RENZI G, PUGIN J, RICOU B, PITTET D

Increased incidence of sexually transmitted infections in Geneva, Switzerland
DERMATOLOGY--
2006 vol. 212 pp. 41-46
ABRAHAM S, TOUTOUS-TRELLU L, PECHERE M, HUGONNET S, LIASSINE N, YERLY S, ROHNER P, NINET B, HIRSCHEL B, PIGUET V

Primary invasive aspergillosis of the digestive tract: report of two cases and review of the literature
INFECTION
2006 vol. 34(6) pp. 333-338
EGGIMANN PHILIPPE, CHEVROLET JEAN-CLAUDE, STAROBINSKI M, MAJNO PIETRO, TOTSCH MARTIN, CHAPUIS BERNARD, PITTET DIDIER

Outbreak of endophthalmitis after cataract surgery: the importance of the quality of the surgical wound
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA
2006 vol. 27(11) pp. 1246-1248
HUGONNET STEPHANE, DOSSO ANDRE, DHARAN SASI, MARTIN YVES, HERRERO MARIA-LUISA, REGNIER CAROLE, PITTET DIDIER

Challenging the world: patient safety and health care-associated infection
INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE
2006 vol. 18 pp. 4-8
PITTET D, DONALDSON L

Clean care is safer care': the Global Patient Safety Challenge 2005-2006
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
2006 vol. 10 pp. 419-424
PITTET D, ALLEGRANZI B, STORR J, DONALDSON L

Rapid Staphylococcus aureus agr type determination by a novel multiplex real-time quantitative PCR assay
JOURNAL OF CLINICAL MICROBIOLOGY
2006 vol. 44 pp. 1892-1895
FRANCOIS P, KOESSLER T, HUYGHE A, HARBARTH S, BENTO M, LEW D, ETIENNE J, PITTET D, SCHRENZEL J

Recurrent osteomyelitis caused by infection with different bacterial strains without obvious source of reinfection
JOURNAL OF CLINICAL MICROBIOLOGY
2006 vol. 44(3) pp. 1194-1196
U�KAY ILKER, ASSAL MATHIEU, LEGOUT LAURENCE, ROHNER PETER, STERN RICHARD, LEW DANIEL, HOFFMEYER PIERRE, BERNARD LOUIS

Use of oligoarrays for characterization of community-onset methicillin-resistant Staphylococcus aureus
JOURNAL OF CLINICAL MICROBIOLOGY
2006 vol. 44 pp. 1040-1048
KOESSLER T, FRANCOIS P, CHARBONNIER Y, HUYGHE A, BENTO M, DHARAN S, RENZI G, LEW D, HARBARTH S, PITTET D, SCHRENZEL J

Control of a cluster of community-associated, methicillin-resistant Staphylocloccus aureus in neonatology
JOURNAL OF HOSPITAL INFECTION
2006 vol. 63 pp. 93-100
SAX H, POSFAY-BARBE K, HARBARTH S, FRANCOIS P, TOUVENEAU S, PESSOA-SILVA CL, SCHRENZEL J, DHARAN S, GERVAIX A, PITTET D

Muslim health-care workers and alcohol-based handrubs
LANCET
2006 vol. 367 pp. 1025-1027
AHMED QA, MEMISH ZA, ALLEGRANZI B, PITTET D

Evidence-based model for hand transmission during patient care and the role of improved practices
LANCET INFECTIOUS DISEASES
2006 vol. 6(10) pp. 641-652
PITTET D, ALLEGRANZI B, SAX H, DHARAN S, PESSOA-SILVA CL, DONALDSON L, BOYCE JM

Postoperative fungal infections
SURGICAL INFECTIONS
2006 vol. 7 Suppl 2 pp. 53-56
EGGIMANN PHILIPPE, PITTET DIDIER

Treatment options of invasive fungal infections in adults
SWISS MEDICAL WEEKLY
2006 vol. 136 pp. 447-463
FLUCKIGER U, MARCHETTI O, BILLE J, EGGIMANN P, ZIMMERLI S, IMHOF A, GARBINO J, RUE C, PITTET D, TAUBER M, GLAUSER M, CALANDRA T

Community-associated methicillin-resistant Staphylococcus aureus, Switzerland
EMERGING INFECTIOUS DISEASES (PRINT)
2005 vol. 11 pp. 962-965
HARBARTH STEPHAN, FRANCOIS PATRICE, SCHRENZEL JACQUES, FANKHAUSER-RODRIGUEZ CAROLINA, HUGONNET STEPHANE, KOESSLER THIBAUD, HUYGHE ANTOINE, PITTET DIDIER

Meticillin-resistant Staphylococcus aureus
LANCET INFECTIOUS DISEASES
2005 vol. 5(10) pp. 653-663
BOYCE JM, COOKSON B, CHRISTIANSEN K, HORI S, VUOPIO-VARKILA J, KOCAG�Z S, OZTOP AY, VANDENBROUCKE-GRAULS CM, HARBARTH S, PITTET D

COST IMPLICATIONS OF SUCCESSFUL HAND HYGIENE PROMOTION
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA
2004 vol. 25 pp. 264-266
PITTET DIDIER, SAX HUGO, HUGONNET STEPHANE, HARBARTH STEPHAN

Reply to letter by Tulleken et al.
INTENSIVE CARE MEDICINE
2004 vol. 30 pp. 998-999
EGGIMANN PHILIPPE, HUGONNET STEPHANE, SAX HUGO, CHEVROLET JEAN-CLAUDE, PITTET DIDIER

Control of multiply resistant cocci: Do international comparisons help?
THE LANCET INFECTIOUS DISEASES
2001 vol. 1 pp. 251-261
HARBARTH STEPHAN, ALBRICH W.C, GOLDMANN D.A, HUBNER J

Risk factors for persistent carriage of methicillin resistant Staphylococcus aureus
CLINICAL INFECTIOUS DISEASES.
2000 vol. 31(6) pp. 1380-1385
HARBARTH S, LIASSINE N, DHARAN S, HERRAULT P, AUCKENTHALER R, PITTET D

Effect of delayed infection control measures on a hospital outbreak of MRSA
JOURNAL OF HOSPITAL INFECTION
2000 vol. 46 pp. 43-49
HARBARTH STEPHAN, MARTIN PIERRE-YVES, ROHNER PETER, HENRY N, AUCKENTHALER R, PITTET DIDIER

Effectiveness of a hospital wide programme to improve compliance with hand hygiene Infection Control Programme
LANCET
2000 vol. 356 pp. 1307-1312
PITTET D, HUGONNET S, HARBARTH S, MOUROUGA P, SAUVAN V, TOUVENEAU S, PERNEGGER TV

Impact of methicillin resistance on the outcome of patients with bacteremia caused by Staphylococcus aureus
ARCHIVES OF INTERNAL MEDICINE
1998 vol. 158 pp. 182-189
HARBARTH STEPHAN, RUTSCHMANN OLIVIER, SUDRE PHILIPPE, PITTET DIDIER

Domaines de recherche

INFECTION NOSOCOMIALE
EPIDEMIOLOGIE
FACTEUR DE RISQUE
HYGIENE HOSPITALIERE
QUALITE DES SOINS




BASE DE DONNÉES-RECHERCHE	GROUPE DE RECHERCHE CLINIQUE ORIENTEE PATIENTS

D. PITTET et S. HARBARTH	CV du Chef de Groupe	Sujet de Recherche	Composition du Groupe


	Coordonnées du groupe Dr. S. HARBARTH HUG/ Dpt Médecine interne Serv Mal. infec. Bat Séminaire Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse stephan.harbarth@hcuge.ch Tél.: 022/372.98.28 Fax: 022/372.39.87 Commentaires Pages générées le 09.02.2010		Sujet de recherche \| Publications du groupe \| Domaines de recherche MRSA Nature du problème Depuis plusieurs années, des infections causées par des souches de staphylocoques dorés résistants à la méthicilline (MRSA) et souvent multi-résistants ont été signalées partout dans le monde. La prévalence de l'infection varie entre 0 et 50 %; elle est plus élevée dans les hôpitaux universitaires, en Suisse comme ailleurs. Situation aux HUG MRSA est un problème aux HUG depuis le début des années 90, en proportion épidémique depuis 1993-1994. Des efforts de contrôle ont été instaurés, avec succès. Malheureusement, nous assistons depuis le milieu de l'année 1999 à une nouvelle augmentation du nombre de cas, qui prend des proportions inquiétantes depuis 2000. Cette épidémie touche tous les secteurs del'institution, à des degrés variables. L'augmentation de l'incidence est attribuée en partie à l'augmentation du réservoir épidémique de provenance extérieure aux HUG. Pourquoi ce problème nous inquiète-t-il ? Les infections à MRSA sont grevées d'un taux important de morbidité et de mortalité. Elles viennent s'ajouter aux autres infections nosocomiales; leur traitement impose le recours à des antibiotiques relativement toxiques, pourvus d'effets secondaires et nécessitant des examens complémentaires pour assurer leur bonne utilisation. Enfin, la transmission intra-hospitalière est le reflet d'un manque de qualité des soins. Prévention Les principales mesures de lutte contre la propagation de l'infection sont l'hygiène des mains, l'identification des patients colonisés ou infectés, les mesures d'isolement destinées à protéger le milieu hospitalier, les précautions lors de transferts, et la réduction du portage. Projets de recherche clinique 1) Identification du réservoir Les objectifs sont : a) recueillir des informations épidémiologiques permettant une lutte globale et une action sur tous les réservoirs de l'épidémie ; b) accélérer la prise en charge et permettre l'orientation optimale des patients porteurs dès l'admission, ainsi que la détection des cas d'entourage ; c) optimaliser l''occupation des chambres d'isolement en ne les utilisant que pour des cas confirmés. 2) Prévention des infections à MRSA aux soins intensifs et mise en place d'un test ultra-rapide Les objectifs sont : a) accélérer la prise en charge et permettre l'isolement précoce de patients colonisés; b) diminuer les taux de transmission croisée et d'infections graves à MRSA. 3) Evaluation retrospective de l'épidémie à MRSA aux HUG L'objectif principal est de mieux comprendre les facteurs qui ont favorisé l'augmentation du nombre de cas MRSA depuis 2000 avec analyse épidémiologique et moléculaire de différentes souches MRSA isolées aux HUG. Publications du groupe Re: help or hindrance? Is current infection control advice applicable in low- and middle-income countries? A review of the literature. AMERICAN JOURNAL OF INFECTION CONTROL 2008 vol. 36(7) pp. 499-501 STORR J, PITTET D Novel microarray design strategy to study complex bacterial communities. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 2008 vol. 74(6) pp. 1876-1885 HUYGHE ANTOINE, FRANCOIS P, CHARBONNIER YVAN, BENTO M, BONETTI EJ, PASTER BJ, BOLIVAR I, BARATTI-MAYER D, PITTET D, SCHRENZEL J Ventilator-associated pneumonia as a quality indicator for patient safety? CLINICAL INFECTIOUS DISEASES 2008 vol. 46(4) pp. 557-563 UCKAY ILKER, AHMED QA, SAX H, PITTET D Healthcare-associated infections: think globally, act locally. CLINICAL MICROBIOLOGY AND INFECTION 2008 vol. 14(10) pp. 895-907 MARCEL JP AND AL. Healthcare-associated infections in neonates. CURRENT OPINION IN INFECTIOUS DISEASES 2008 vol. 21(3) pp. 228-234 ZINGG W, POSFAY-BARBE KLARA, PITTET D Methicillin-resistant Staphylococcus aureus, Geneva, Switzerland, 1993-2005. EMERGING INFECTIOUS DISEASES (PRINT) 2008 vol. 14(2) pp. 304-307 FRANCOIS P, HARBARTH S, HUYGHE ANTOINE, RENZI G, BENTO M, GERVAIX A, PITTET D, SCHRENZEL J Commentary: hand hygiene: it's all about when and how. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 2008 vol. 29(10) pp. 957-959 PITTET D Trial of alcohol-based hand gel in critical care units. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY 2008 vol. 29(6) pp. 577-579 MERMEL LA, BOYCE JM, VOSS A, ALLEGRANZI B, PITTET D Effect of screening for methicillin-resistant Staphylococcus aureus carriage by polymerase chain reaction on the duration of unnecessary preemptive contact isolation. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2008 vol. 29(11) pp. 1077-1079 UCKAY ILKER, SAX H, ITEN A, CAMUS V, RENZI G, SCHRENZEL J, PERRIER A, PITTET D Risk factors for methicillin-resistant Staphylococcus aureus surgical site infection. INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2008 vol. 29(9) pp. 890-893 HARBARTH S, HUTTNER B, GERVAZ P, FANKHAUSER C, CHRAITI MARIE-NOELLE, SCHRENZEL J, LICKER M, PITTET D Universal screening for methicillin-resistant Staphylococcus aureus at hospital admission and nosocomial infection in surgical patients. JAMA 2008 vol. 299(10) pp. 1149-1157 HARBARTH S, FANKHAUSER C, SCHRENZEL J, CHRISTENSON JAN, GERVAZ P, BANDIERA-CLERC C, RENZI G, VERNAZ N, SAX H, PITTET D Antibiotic prophylaxis before invasive dental procedures in patients with arthroplasties of the hip and knee. JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME 2008 vol. 90(7) pp. 833-838 UCKAY ILKER, PITTET D, BERNARD L, LEW D, PERRIER A, PETER R Infection control as a major World Health Organization priority for developing countries. JOURNAL OF HOSPITAL INFECTION 2008 vol. ;68(4) pp. 285-292 PITTET D, ALLEGRANZI B, STORR J, BAGHERI NEJAD S, DZIEKAN G, LEOTSAKOS A, DONALDSON L Multi-resistant infections in repatriated patients after natural disasters: lessons learned from the 2004 tsunami for hospital infection control. JOURNAL OF HOSPITAL INFECTION 2008 vol. 68(1) pp. 1-8 UCKAY ILKER, SAX H, HARBARTH S, BERNARD L, PITTET D Rapid and high-throughput genotyping of Staphylococcus epidermidis isolates by automated multilocus variable-number of tandem repeats: a tool for real-time epidemiology. JOURNAL OF MICROBIOLOGICAL METHODS 2008 vol. 72(3) pp. 296-305 FRANCOIS P, HOCHMANN A, HUYGHE ANTOINE, BONETTI EJ, RENZI G, HARBARTH S, KLINGENBERG C, PITTET D, SCHRENZEL J A predictive model for identifying surgical patients at risk of methicillin-resistant Staphylococcus aureus carriage on admission. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS 2008 vol. 207(5) pp. 683-689 HARBARTH S, SAX H, UCKAY ILKER, FANKHAUSER C, AGOSTINHO A, CHRISTENSON JT, RENZI G, SCHRENZEL J, PITTET D Preventing infections acquired during health-care delivery. LANCET 2008 vol. 372(9651) pp. 1719-1720 PITTET D, ALLEGRANZI B Alcohol-based rubs for hand antisepsis. LANCET INFECTIOUS DISEASES 2008 vol. 8(10) pp. 585-586 PITTET D, DHARAN S Infection control in paediatrics. LANCET INFECTIOUS DISEASES 2008 vol. ;8(1) pp. 19-31 POSFAY-BARBE, ZERR DM, PITTET D Cefuroxime prophylaxis is effective in noninstrumented spine surgery: a double-blind, placebo-controlled study. SPINE 2008 vol. 33(18) pp. 1919-1924 PETIGNAT C AND AL. Comment on: Control of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae using a computer-assisted management program to restrict third-generation cephalosporin use. THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2008 vol. 62(5) pp. 1165-1165 HUTTNER B, PITTET D, HARBARTH S Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile. THE JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2008 vol. 62(3) pp. 601-607 VERNAZ N, SAX H, PITTET D, BONNABRY P, SCHRENZEL J, HARBARTH S Evaluation of three molecular assays for rapid identification of methicillin-resistant Staphylococcus aureus JOURNAL OF CLINICAL MICROBIOLOGY 2007 vol. 45 pp. 2011-2013 FRANCOIS P, BENTO M, RENZI G, HARBARTH S, PITTET D, SCHRENZEL J Skin reactions related to hand hygiene and selection of hand hygiene products AMERICAN JOURNAL OF INFECTION CONTROL 2006 vol. 34 pp. 627-635 LARSON E, GIRARD R, PESSOA-SILVA CL, BOYCE J, DONALDSON L, PITTET D Evaluating the probability of previously unknown carriage of MRSA at hospital admission AMERICAN JOURNAL OF MEDICINE 2006 vol. 119(3) pp. 275-275 HARBARTH S, SAX H, FANKHAUSER-RODRIGUEZ C, SCHRENZEL J, AGOSTINHO A, PITTET D A randomized double-blind trial of iseganan in prevention of ventilator-associated pneumonia AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006 vol. 173 pp. 91-97 KOLLEF M, PITTET D, GARCIA MS, CHASTRE J, FAGON JY, BONTEN M, HYZY R, FLEMING TR, FUCHS H, BELLM L, MERCAT A, MANEZ R, MARTINEZ A, EGGIMANN P, DAGUERRE M, LUYT CE Procalcitonin Guidance of Antibiotic Therapy in Community-acquired Pneumonia: A Randomized Trial AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2006 vol. 174(1) pp. 84-93 CHRIST-CRAIN MIRJAM ET AL. Recurrent bacteremia with Helicobacter cinaedi: case report and review of the literature BMC INFECTIOUS DISEASES 2006 vol. 6 pp. 86-86 UCKAY I, GARBINO J, DIETRICH PY, NINET B, ROHNER P, JACOMO V Reduction of urinary tract infection and antibiotic use after surgery: A controlled, prospective, befor after intervention study CLINICAL INFECTIOUS DISEASES 2006 vol. 42 pp. 1544-1551 STEPHAN F, SAX H, WACHSMUTH M, HOFFMEYER P, CLERGUE F, PITTET D Evaluation of rapid screening and pre-emptive contact isolation for detecting and controlling methicillin-resistant Staphylococcus aureus in critical care: an interventional cohort study CRITICAL CARE 2006 vol. 10 pp. 0-0 HARBARTH S, MASUET-AUMATELL C, SCHRENZEL J, FRANCOIS P, AKAKPO C, RENZI G, PUGIN J, RICOU B, PITTET D Increased incidence of sexually transmitted infections in Geneva, Switzerland DERMATOLOGY-- 2006 vol. 212 pp. 41-46 ABRAHAM S, TOUTOUS-TRELLU L, PECHERE M, HUGONNET S, LIASSINE N, YERLY S, ROHNER P, NINET B, HIRSCHEL B, PIGUET V Primary invasive aspergillosis of the digestive tract: report of two cases and review of the literature INFECTION 2006 vol. 34(6) pp. 333-338 EGGIMANN PHILIPPE, CHEVROLET JEAN-CLAUDE, STAROBINSKI M, MAJNO PIETRO, TOTSCH MARTIN, CHAPUIS BERNARD, PITTET DIDIER Outbreak of endophthalmitis after cataract surgery: the importance of the quality of the surgical wound INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2006 vol. 27(11) pp. 1246-1248 HUGONNET STEPHANE, DOSSO ANDRE, DHARAN SASI, MARTIN YVES, HERRERO MARIA-LUISA, REGNIER CAROLE, PITTET DIDIER Challenging the world: patient safety and health care-associated infection INTERNATIONAL JOURNAL FOR QUALITY IN HEALTH CARE 2006 vol. 18 pp. 4-8 PITTET D, DONALDSON L Clean care is safer care': the Global Patient Safety Challenge 2005-2006 INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES 2006 vol. 10 pp. 419-424 PITTET D, ALLEGRANZI B, STORR J, DONALDSON L Rapid Staphylococcus aureus agr type determination by a novel multiplex real-time quantitative PCR assay JOURNAL OF CLINICAL MICROBIOLOGY 2006 vol. 44 pp. 1892-1895 FRANCOIS P, KOESSLER T, HUYGHE A, HARBARTH S, BENTO M, LEW D, ETIENNE J, PITTET D, SCHRENZEL J Recurrent osteomyelitis caused by infection with different bacterial strains without obvious source of reinfection JOURNAL OF CLINICAL MICROBIOLOGY 2006 vol. 44(3) pp. 1194-1196 U�KAY ILKER, ASSAL MATHIEU, LEGOUT LAURENCE, ROHNER PETER, STERN RICHARD, LEW DANIEL, HOFFMEYER PIERRE, BERNARD LOUIS Use of oligoarrays for characterization of community-onset methicillin-resistant Staphylococcus aureus JOURNAL OF CLINICAL MICROBIOLOGY 2006 vol. 44 pp. 1040-1048 KOESSLER T, FRANCOIS P, CHARBONNIER Y, HUYGHE A, BENTO M, DHARAN S, RENZI G, LEW D, HARBARTH S, PITTET D, SCHRENZEL J Control of a cluster of community-associated, methicillin-resistant Staphylocloccus aureus in neonatology JOURNAL OF HOSPITAL INFECTION 2006 vol. 63 pp. 93-100 SAX H, POSFAY-BARBE K, HARBARTH S, FRANCOIS P, TOUVENEAU S, PESSOA-SILVA CL, SCHRENZEL J, DHARAN S, GERVAIX A, PITTET D Muslim health-care workers and alcohol-based handrubs LANCET 2006 vol. 367 pp. 1025-1027 AHMED QA, MEMISH ZA, ALLEGRANZI B, PITTET D Evidence-based model for hand transmission during patient care and the role of improved practices LANCET INFECTIOUS DISEASES 2006 vol. 6(10) pp. 641-652 PITTET D, ALLEGRANZI B, SAX H, DHARAN S, PESSOA-SILVA CL, DONALDSON L, BOYCE JM Postoperative fungal infections SURGICAL INFECTIONS 2006 vol. 7 Suppl 2 pp. 53-56 EGGIMANN PHILIPPE, PITTET DIDIER Treatment options of invasive fungal infections in adults SWISS MEDICAL WEEKLY 2006 vol. 136 pp. 447-463 FLUCKIGER U, MARCHETTI O, BILLE J, EGGIMANN P, ZIMMERLI S, IMHOF A, GARBINO J, RUE C, PITTET D, TAUBER M, GLAUSER M, CALANDRA T Community-associated methicillin-resistant Staphylococcus aureus, Switzerland EMERGING INFECTIOUS DISEASES (PRINT) 2005 vol. 11 pp. 962-965 HARBARTH STEPHAN, FRANCOIS PATRICE, SCHRENZEL JACQUES, FANKHAUSER-RODRIGUEZ CAROLINA, HUGONNET STEPHANE, KOESSLER THIBAUD, HUYGHE ANTOINE, PITTET DIDIER Meticillin-resistant Staphylococcus aureus LANCET INFECTIOUS DISEASES 2005 vol. 5(10) pp. 653-663 BOYCE JM, COOKSON B, CHRISTIANSEN K, HORI S, VUOPIO-VARKILA J, KOCAG�Z S, OZTOP AY, VANDENBROUCKE-GRAULS CM, HARBARTH S, PITTET D COST IMPLICATIONS OF SUCCESSFUL HAND HYGIENE PROMOTION INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY : THE OFFICIAL JOURNAL OF THE SOCIETY OF HOSPITAL EPIDEMIOLOGISTS OF AMERICA 2004 vol. 25 pp. 264-266 PITTET DIDIER, SAX HUGO, HUGONNET STEPHANE, HARBARTH STEPHAN Reply to letter by Tulleken et al. INTENSIVE CARE MEDICINE 2004 vol. 30 pp. 998-999 EGGIMANN PHILIPPE, HUGONNET STEPHANE, SAX HUGO, CHEVROLET JEAN-CLAUDE, PITTET DIDIER Control of multiply resistant cocci: Do international comparisons help? THE LANCET INFECTIOUS DISEASES 2001 vol. 1 pp. 251-261 HARBARTH STEPHAN, ALBRICH W.C, GOLDMANN D.A, HUBNER J Risk factors for persistent carriage of methicillin resistant Staphylococcus aureus CLINICAL INFECTIOUS DISEASES. 2000 vol. 31(6) pp. 1380-1385 HARBARTH S, LIASSINE N, DHARAN S, HERRAULT P, AUCKENTHALER R, PITTET D Effect of delayed infection control measures on a hospital outbreak of MRSA JOURNAL OF HOSPITAL INFECTION 2000 vol. 46 pp. 43-49 HARBARTH STEPHAN, MARTIN PIERRE-YVES, ROHNER PETER, HENRY N, AUCKENTHALER R, PITTET DIDIER Effectiveness of a hospital wide programme to improve compliance with hand hygiene Infection Control Programme LANCET 2000 vol. 356 pp. 1307-1312 PITTET D, HUGONNET S, HARBARTH S, MOUROUGA P, SAUVAN V, TOUVENEAU S, PERNEGGER TV Impact of methicillin resistance on the outcome of patients with bacteremia caused by Staphylococcus aureus ARCHIVES OF INTERNAL MEDICINE 1998 vol. 158 pp. 182-189 HARBARTH STEPHAN, RUTSCHMANN OLIVIER, SUDRE PHILIPPE, PITTET DIDIER Domaines de recherche INFECTION NOSOCOMIALE EPIDEMIOLOGIE FACTEUR DE RISQUE HYGIENE HOSPITALIERE QUALITE DES SOINS