BASE DE DONNÉES-RECHERCHE | GROUPE DE RECHERCHE CLINIQUE ORIENTEE PATIENTS | ||||||
Maurice BEGHETTI | CV du Chef de Groupe | Sujet de Recherche | Composition du Groupe |
Coordonnées du groupe
Pr. M. BEGHETTI HUG/ Dpt Pédiatrie Hôp. Enfants/ Cardiopédiatrie Rue Willy Donzé 6 1205 Genève Suisse maurice.beghetti@hcuge.ch Tél.: 022/382.45.80 Fax: 022/382.45.46 Commentaires Pages générées le 17.11.2015 |
Sujet de recherche
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Publications du groupe
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Domaines de recherche
L'hypertension pulmonaire
L'hypertension pulmonaire a connu ces dernières années une révolution tant dans la compréhension de ces mécanismes physiopathologiques que sur la thérapeutique. Par exemple pour l'Hypertension
artérielle pulmonaire on est passé d'une maladie orpheline sans traitement et survie médiane de 2.5 ans à une sensible amélioration avec l'apparition de nouvelles thérapeutique (prostacyline, inhibiteurs
de la phosphodiesterase type 5, antagonistes de récepteurs de l'endotheline, etc.) mais malheureusement sans cure définitive pour la majorité des patients. Les patients pédiatriques sont toujours les
parents pauvres et actuellement on s'adapte à l'apparition des traitements chez l'adulte de ces nouvelles thérapies.
Nos travaux actuels concernent l'étiologie et l'épidémiologie de l'hypertension pulmonaire à l'aide de la création de registre en suisse et en France et plus récemment sur le plan international. Conjointement nous participons à de nombreux comités pour la mise en route d'étude spécifiquement pédiatrique avec les nouvelles thérapies ainsi que le développement d'une nouvelle formulation spécifiquement pédiatrique pour l'une d'entre elles. Il y a également plusieurs travaux cliniques effectués avec d'autres collègues et centres sur des pathologie plus spécifiques impliquant l'hypertension pulmonaire et les cardiopathies congénitales (Prof Fineman University San Francisco California (prévention du rebond à l'arrêt de traitement de monoxyde d'azote, Hypertension pulmonaire et CEC) et Le Prof Schulze Neick, Great Ormond Street London (hypertension pulmonaire et CEC, Anastomose cavopulmonaire et lit vasculaire pulmonaire)Sur le plan fondamental 2 collaborations Dr Habre anesthésie pédiatrique Genève Prof Humbert Centre de référence des maladies vasculaire pulmonaire Paris ce travail consiste à analyser des biopsies pulmonaires de patients opérés de cardiopathies congénitales dans le but d¿élucider les mécanismes des lésions plus particulièrement la possibilité du rôle de l¿inflammation dans l¿apparition de ces lésions en ensuite réfléchir aux potentielles cibles thérapeutiques. L¿obésité de l¿enfant représente un véritable challenge de santé publique et il semble que les premières bases des maladies cardiovasculaires et du diabète se constituent pendant l¿enfance. Dans une étude récente, nous avons démontré que les enfants obèses présentent déjà avant la puberté de multiples facteurs de risque : une altération des fonctions endothéliale et du muscle lisse de l¿artère brachiale, une augmentation de la rigidité artérielle, de la pression artérielle, de la graisse abdominale, de la résistance à l¿insuline, ainsi qu¿une baisse du cholestérol-HDL, du fitness cardiorespiratoire, de l¿activité physique, et de la qualité de vie. Nous avons effectué un essai clinique randomisé et démontré qu¿un programme d¿exercice physique modéré pendant 3 mois améliore significativement ces facteurs de risque, en particulier la pression artérielle et l¿épaississement de la paroi, le pourcentage de graisse corporelle, le niveau d¿activité physique, le fitness cardiorespiratoire et la qualité de vie. Nous n¿avons pas observé d¿effets sur la fonction endothéliale ou sur la résistance à l¿insuline, ce qui peut être dû à une durée ou à une intensité d¿entraînement insuffisante, ou à un mode de vie inadéquat dans la famille. Nous planifions maintenant un essai clinique randomisé pour évaluer les effets d¿un programme d¿exercice seul ou combiné à une thérapie comportementale de groupe (éducation, soutien) pour les enfants et les parents pendant 6 mois. Ces résultats seront importants pour soutenirle développement d¿une nouvelle thérapie nationale de l¿obésité de l¿enfant en Suisse. Publications du groupe Homografts and xenografts for right ventricular outflow tract reconstruction: long-term results. ANNALS OF THORACIC SURGERY 2010 vol. 90(4) pp. 1287-1293 CHRISTENSON JT, SIERRA J, COLINA MANZANO NE, JOLOU J, BEGHETTI M, KALANGOS A No-patch technique for complete atrioventricular canal repair. ANNALS OF THORACIC SURGERY 2010 vol. 90(1) pp. 317-319 MYERS PO, CIKIRIKCIOGLU M, AGGOUN Y, MURITH N, KALANGOS A Characteristics and prospective 2-year follow-up of children with pulmonary arterial hypertension in France. ARCHIVES OF CARDIOVASCULAR DISEASES 2010 vol. 103(2) pp. 66-74 FRAISSE A AND AL. Assessment of endpoints in the pediatric population: congenital heart disease and idiopathic pulmonary arterial hypertension. CURRENT OPINION IN PULMONARY MEDICINE 2010 vol. 16 pp. 35-41 HAWORTH SG, BEGHETTI M ESC Guidelines for the management of grown-up congenital heart disease (new version 2010). EUROPEAN HEART JOURNAL 2010 vol. 31(23) pp. 2915-2957 BAUMGARTNER H. AND AL. Tetralogy of Fallot with absent pulmonary valve, supracardiac total anomalous pulmonary venous connection, and infradiaphragmatic systemic to pulmonary collateral artery. EUROPEAN HEART JOURNAL 2010 vol. 31(24) pp. 3005-3005 MYERS PO, KALANGOS A, DIDIER D, TISSOT C Stairs instead of elevators at workplace: cardioprotective effects of a pragmatic intervention. EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION 2010 vol. 17(5) pp. 569-575 MEYER P, KAYSER B, KOSSOVSKY MP, SIGAUD P, CARBALLO D, KELLER P, MARTIN X, FARPOUR-LAMBERT N, PICHARD C, MACH F Reduced physical activity level and cardiorespiratory fitness in children with chronic diseases. EUROPEAN JOURNAL OF PEDIATRICS 2010 vol. 169(10) pp. 1187-1193 MAGGIO A, HOFER M, MARTIN X, MARCHAND L, BEGHETTI M, FARPOUR-LAMBERT N Precapillary pulmonary hypertension leads to reversible bronchial hyperreactivity in rats. EXPERIMENTAL LUNG RESEARCH 2010 vol. 36(3) pp. 129-139 VON UNGERN-STERNBERG BS, HABRE W, REGLI A, PACHE JC, FONTAO F, JANOSI T, BEGHETTI M, PETAK F Fontan and the pulmonary circulation: a potential role for new pulmonary hypertension therapies. HEART 2010 vol. 96(12) pp. 911-916 BEGHETTI M Central venous hypoxemia is a determinant of human atrial ATP-sensitive potassium channel expression: evidence for a novel hypoxia-inducible factor 1alpha-Forkhead box class O signaling pathway. HYPERTENSION 2010 vol. 55(5) pp. 1186-1192 RAEIS V, PHILIP-COUDERC P, ROATTI A, HABRE W, SIERRA J, KALANGOS A, BEGHETTI M, BAERTSCHI AJ Surfactant use based on the oxygenation response to lung recruitment during HFOV in VLBW infants. INTENSIVE CARE MEDICINE 2010 vol. 36(7) pp. 1164-1170 TISSIERES P, MYERS PO, BEGHETTI M, BERNER M, RIMENSBERGER PC Atrial septal defects versus ventricular septal defects in BREATHE-5, a placebo-controlled study of pulmonary arterial hypertension related to Eisenmenger's syndrome: a subgroup analysis. INTERNATIONAL JOURNAL OF CARDIOLOGY 2010 vol. 144(3) pp. 373-378 BERGER RM, BEGHETTI M, GALIE N, GATZOULIS MA, GRANTON J, LAUER A, CHIOSSI E, LANDZBERG M Decreased bone turnover in children and adolescents with well controlled type 1 diabetes. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM : JPEM 2010 vol. 23(7) pp. 697-707 MAGGIO A, FERRARI S, KRAENZLIN M, MARCHAND L, SCHWITZGEBEL V, BEGHETTI M, RIZZOLI R, FARPOUR-LAMBERT N Assessment of muscular performance in teenagers after a lower extremity fracture. JOURNAL OF PEDIATRIC ORTHOPEDICS 2010 vol. 30(8) pp. 807-812 CERONI D, MARTIN X, FARPOUR-LAMBERT N, DELHUMEAU C, KAELIN A Medical therapy for pediatric pulmonary arterial hypertension. JOURNAL OF PEDIATRICS 2010 vol. 157(4) pp. 528-532 TISSOT C, IVY DD, BEGHETTI M Preclinical noninvasive markers of atherosclerosis in children and adolescents with type 1 diabetes are influenced by physical activity. JOURNAL OF PEDIATRICS 2010 vol. 157(4) pp. 533-539 TRIGONA B, AGGOUN Y, MAGGIO A, MARTIN X, MARCHAND L, BEGHETTI M, FARPOUR-LAMBERT N Aortic valve repair by cusp extension for rheumatic aortic insufficiency in children: Long-term results and impact of extension material. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 2010 vol. 140(4) pp. 836-844 MYERS PO, TISSOT C, CHRISTENSON JT, CIKIRIKCIOGLU M, AGGOUN Y, KALANGOS A Leaflet suspension to the contralateral annulus to address restriction or tethering-induced mitral and tricuspid regurgitation in children: results of a case-control study. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 2010 vol. 140(5) pp. 1110-1116 MYERS PO, CHRISTENSON JT, CIKIRIKCIOGLU M, TISSOT C, AGGOUN Y, KALANGOS A Pulmonary hypertension in congenital shunts. REVISTA ESPANOLA DE CARDIOLOGIA 2010 vol. 63(10) pp. 1179-1193 BEGHETTI M, TISSOT C Vagal bradycardia at term. ACTA PAEDIATRICA (OSLO, NORWAY : 1992) 2009 vol. 98(5) pp. 901-903 DELCO C, BEGHETTI M, PFISTER R Pharmacokinetic and clinical profile of a novel formulation of bosentan in children with pulmonary arterial hypertension: the FUTURE-1 study BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2009 vol. 68(6) pp. 948-955 BEGHETTI M AND AL. Early postoperative care of patients with pulmonary hypertension associated with congenital cardiac disease CARDIOLOGY IN THE YOUNG 2009 vol. 19 pp. 315-319 ADATIA I, BEGHETTI M Immediate postoperative care. CARDIOLOGY IN THE YOUNG 2009 vol. 19 pp. 23-27 ADATIA I, BEGHETTI M Bosentan in pediatric patients with pulmonary arterial hypertension. CURRENT VASCULAR PHARMACOLOGY 2009 vol. 7(2) pp. 225-233 BEGHETTI M Guidelines for the diagnosis and treatment of pulmonary hypertension: The Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the Europ ean Respiratory Society (ERS), endorsed by the International Society of Heart and Lung Transplantation (ISHLT). EUROPEAN HEART JOURNAL 2009 vol. 30(20) pp. 2493-2537 GALIE N AND AL. Guidelines for the diagnosis and treatment of pulmonary hypertension. EUROPEAN RESPIRATORY JOURNAL 2009 vol. 34(6) pp. 1219-1263 GALIE N AND AL. Rescue circumflex artery stenting for major right ventricular dysfunction after Ross-Konno operation. HEART SURGERY FORUM 2009 vol. 12(4) pp. 208-210 MYERS PO, AGGOUN Y, CIKIRIKCIOGLU M, KALANGOS A VGAM induced high-flow congestive heart failure responsive to PGE1 infusion. INTERNATIONAL JOURNAL OF CARDIOLOGY 2009 vol. 132(2) pp. 60-62 KARAM O, DA CRUZ E, RIMENSBERGER PC Transpulmonary stenting of both pulmonary arteries with a surgical access through redo sternotomy. JOURNAL OF CARDIAC SURGERY 2009 vol. 24(4) pp. 451-453 AGGOUN Y, SIERRA J, KALANGOS A Pneumonia and pericarditis in a child with HRV-C infection: A case report JOURNAL OF CLINICAL VIROLOGY 2009 vol. 45(2) pp. 157-160 TAPPAREL C, L'HUILLIER AG, ROUGEMONT AL, BEGHETTI M, BARAZZONE-ARGIROFFO C, KAISER L Eisenmenger syndrome a clinical perspective in a new therapeutic era of pulmonary arterial hypertension. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2009 vol. 53(9) pp. 733-740 BEGHETTI M, GALIE N Physical Activity Reduces Systemic Blood Pressure and Improves Early Markers of Atherosclerosis in Pre-Pubertal Obese Children JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2009 vol. 54 pp. 2396-2406 FARPOUR-LAMBERT N, AGGOUN Y, MARCHAND L, MARTIN X, AGGOUN Y, MARCHAND LM, MARTIN XE, HERRMANN FR, BEGHETTI M, HERRMANN FR, BEGHETTI M Updated clinical classification of pulmonary hypertension. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2009 vol. 54 pp. 43-54 SIMMONEAU G AND AL. Pulmonary arterial hypertension and congenital heart disease: targeted therapies and operability. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 2009 vol. 138(3) pp. 785-786 BEGHETTI M, TISSOT C Vascular ultrasound studies for the non-invasive assessment of vascular flow and patency in experimental surgery in the pig. LABORATORY ANIMALS 2009 vol. 43(4) pp. 333-337 OSORIO-DA CRUZ SM, AGGOUN Y, CIKIRIKCIOGLU M, KHABIRI E, DJEBAILI K, KALANGOS A, WALPOTH BH Pulmonary arterial hypertension in congenital heart diseases. SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE 2009 vol. 30(4) pp. 421-428 BEGHETTI M, TISSOT C Biodegradable mitral annuloplasty for congenital ischemic mitral regurgitation. THE THORACIC AND CARDIOVASCULAR SURGEON 2009 vol. 57(6) pp. 363-364 MYERS PO, BEGHETTI M, KALANGOS A Mitral valve repair for rheumatic valve disease in children: midterm results and impact of the use of a biodegradable mitral ring. ANNALS OF THORACIC SURGERY 2008 vol. 86(1) pp. 161-168 KALANGOS A, CHRISTENSON JT, BEGHETTI M, CIKIRIKCIOGLU M, KAMENTSIDIS D, AGGOUN Y Treatment of idiopathic pulmonary arterial hypertension in pediatrics ARCHIVES DE PEDIATRIE 2008 vol. 15(5) pp. 702-704 BEGHETTI M Sex-specific developmental changes in muscle size and bone geometry at the femoral shaft. BONE 2008 vol. ;42(5) pp. 982-989 HOGLER W, BLIMKIE CJ, COWELL CT, INGLIS, RAUCH F, KEMPF AF, WIEBE P, DUNCAN S, FARPOUR-LAMBERT N, WOODHEAD HJ Classifying pulmonary hypertension in the setting of the congenitally malformed heart--cleaning up a dog's dinner. CARDIOLOGY IN THE YOUNG 2008 vol. 18(1) pp. 22-25 SCHULZE-NEICK I, BEGHETTI M Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure. EUROPEAN HEART JOURNAL 2008 vol. 29(6) pp. 792-799 AGGOUN Y, FARPOUR-LAMBERT N, MARCHAND L, GOLAY E, MAGGIO A, BEGHETTI M Differential roles of endothelin-1 ETA and ETB receptors and vasoactive intestinal polypeptide in regulation of the airways and the pulmonary vasculature in isolated rat lung.² EXPERIMENTAL PHYSIOLOGY 2008 vol. 93(11) pp. 1210-1219 JANOSI T, PETAK F, FONTAO F, MOREL DR, BEGHETTI M, HABRE W A DNA resequencing array for pathogenic mutation detection in hypertrophic cardiomyopathy. HUMAN MUTATION 2008 vol. 29(6) pp. 879-885 FOKSTUEN S AND AL Value of brain natriuretic peptide in the perioperative follow-up of children with valvular disease. INTENSIVE CARE MEDICINE 2008 vol. 34(6) pp. 1109-1113 TISSIERES P, DA CRUZ E, HABRE W, AGGOUN Y, MENSI N, KALANGOS A, BEGHETTI M Longer-term bosentan therapy improves functional capacity in Eisenmenger syndrome: results of the BREATHE-5 open-label extension study. INTERNATIONAL JOURNAL OF CARDIOLOGY 2008 vol. 127(1) pp. 27-32 GATZOULIS MA AND AL. Mechanical support availability in pediatric cardiac surgery: program size should not matter. INTERNATIONAL JOURNAL OF CARDIOLOGY 2008 vol. 129(2) pp. 282-284 DA CRUZ EM, BEGHETTI M, KALANGOS A, BERNER M, SIERRA J, AGGOUN Y, TISSOT C, PELLEGRINI M, SAUDAN S, HABRE W, RIMENSBERGER PC Associations among obesity, blood pressure, and left ventricular mass. JOURNAL OF PEDIATRICS 2008 vol. 152(4) pp. 489-493 MAGGIO A, AGGOUN Y, MARCHAND L, MARTIN X, HERRMANN F, BEGHETTI M, FARPOUR-LAMBERT N Short- and long-term effects of inhaled iloprost therapy in children with pulmonary arterial hypertension. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2008 vol. ;51(2) pp. 161-169 IVY DD AND AL. Acute angulation of the aortic arch predisposes a patient to ascending aortic dilatation and aortic regurgitation late after the arterial switch operation for transposition of the great arteries. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 2008 vol. 135(3) pp. 568-572 AGNOLETTI P, CELERMAJER DS, BOUDJEMLINE Y, MARINI D, BONNET D, AGGOUN Y Weight-bearing bones are more sensitive to physical exercise in boys than in girls during pre- and early puberty: a cross-sectional study. OSTEOPOROSIS INTERNATIONAL 2008 vol. 19(12) pp. 1749-1758 KRIEMLER S, ZAHNER L, PUDER JJ, BRAUN-FAHRLÄNDER C, SCHINDLER C, FARPOUR-LAMBERT N, KRÄNZLIN M, RIZZOLI R Bronchoscopic diagnosis of asymptomatic unilateral pulmonary vein atresia in an infant. PEDIATRIC CARDIOLOGY 2008 vol. 29(5) pp. 976-979 TISSOT C, CORBELLI R, AGGOUN Y, BEGHETTI M, DA CRUZ E Effects of single-leg drop-landing exercise from different heights on skeletal adaptations in prepubertal girls: a randomized controlled study. PEDIATRIC EXERCISE SCIENCE 2008 vol. 20(2) pp. 211-228 WIEBE PN, BLIMKIE CJ, FARPOUR-LAMBERT N, BRIODY J, MARSH D, KEMP A, COWELL C, HOWMAN-GILES R Safety experience with bosentan in 146 children 2-11 years old with pulmonary arterial hypertension: results from the European Postmarketing Surveillance program. PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2008 vol. 64(2) pp. 200-204 BEGHETTI M, HOEPER MM, KIELY DG, CARLSEN J, SCHWIERIN B, SEGAL ES, HUMBERT M Pulmonary arterial hypertension in children: new therapeutic approaches ANNALES FRANCAISES D'ANESTHESIE ET DE REANIMATION 2007 vol. 26(6) pp. 570-575 BEGHETTI M Right ventricular outflow tract reconstruction: What conduit to use? Homograft or Contegra? ANNALS OF THORACIC SURGERY 2007 vol. 84 pp. 606-611 SIERRA J, CHRISTENSON JT, LAHLAIDI NH, BEGHETTI M, KALANGOS A The Lecompte maneuver as an alternative to reduction pulmonary arterioplasty for relief of airway compression in absent pulmonary valve syndrome. ANNALS OF THORACIC SURGERY 2007 vol. 83(2) pp. 727-728 TISSOT C, AGGOUN Y, BEGHETTI M, DA CRUZ E, SIERRA J, KALANGOS A Re: Systematic placement of left-sided pacing leads as an appealing option for cardiac resynchronization as treatment of congestive cardiac failure in children dependent on chronic cardiac pacing CARDIOLOGY IN THE YOUNG 2007 vol. 17 pp. 234-235 DA CRUZ E, AGGOUN Y, TISSOT C, BEGHETTI M Rescue left main coronary artery stenting for acute myocardial ischemia after coronary angiography in a 7-year-old girl with homozygous familial hypercholesterolemia CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIAC ANGIOGRAPHY & INTERVENTIONS 2007 vol. 69 pp. 243-247 TISSOT C, DA CRUZ E, AGGOUN Y A giant congenital left ventricular diverticulum simulating an aneurysm EUROPEAN HEART JOURNAL 2007 vol. 28 pp. 25-25 TISSOT C, PACHE JC, DA CRUZ E A neonate with isolated combined aortic and pulmonary valvar stenosis. INTERNATIONAL JOURNAL OF CARDIOLOGY 2007 vol. 116(1) pp. 13-14 DA CRUZ EDUARDO, BILLIEUX MH, BEGHETTI M Left ventricular epicardial VVI pacing for a congenital complete heart block with severe myocardial dysfunction: shall epicardial pacing wires be positioned left? INTERNATIONAL JOURNAL OF CARDIOLOGY 2007 vol. 116(1) pp. 7-9 TISSOT CECILE, AGGOUN YACINE, RIMENSBERGER PETER C., SIERRA JORGE, KALANGOS AFKSENDYIOS, BEGHETTI MAURICE, DA CRUZ EDUARDO Successful use of a new Amplatzer Vascular plug for percutaneous closure of a large aortopulmonary collateral artery in a pulmonary atresia with ventricular septal defect prior to complete repair. INTERNATIONAL JOURNAL OF CARDIOLOGY 2007 vol. 116(2) pp. 39-41 TISSOT C, DA CRUZ E, BEGHETTI M, AGGOUN Y Enhanced intimal thickening of expanded polytetrafluoroethylene grafts coated with fibrin or fibrin-releasing vascular endothelial growth factor in the pig carotid artery interposition model JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 2007 vol. 133 pp. 1163-1170 WALPOTH BH, ZAMMARETTI P, CIKIRIKCIOGLU M, KHABIRI E, DJEBAILI MK, PACHE JC, TILLE JC, AGGOUN Y, MOREL D, KALANGOS A, HUBBELL JA, ZISCH AH Cardiac rhythm and left ventricular function of infants at 1 MAC sevoflurane and halothane PEDIATRIC ANESTHESIA 2007 vol. 17(6) pp. 540-546 SAUDAN S, BEGHETTI M, SPAHR-SCHOPFER I, MAMIE C, HABRE W Tissue plasminogen activator for a left atrial thrombus after Senning repair. PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES 2007 vol. 8(3) pp. 279-281 TISSOT C, RIMENSBERGER PC, AGGOUN Y, KALANGOS A, OZSAHIN H, BEGHETTI M, DA CRUZ E Postoperative gram-negative anaerobic bacterial endocarditis PEDIATRIC INFECTIOUS DISEASE JOURNAL 2007 vol. 26 pp. 369-369 MYERS C, AGGOUN Y, GERVAIX A, NINET B, SCHRENZEL J, KUHNERT P Obesity, metabolic syndrome, and cardiovascular disease. PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2007 vol. 61(6) pp. 653-659 AGGOUN Y The Swiss registry for pulmonary arterial hypertension: the paediatric experience SWISS MEDICAL WEEKLY 2007 vol. 137 pp. 510-513 FASNACHT MS, TOLSA JF, BEGHETTI M Bosentan therapy in patients with Eisenmenger syndrome: a multicenter, double-blind, randomized, placebo-controlled study CIRCULATION 2006 vol. 114(1) pp. 48-54 GALIE NAZZARENO, BEGHETTI MAURICE, GATZOULIS MICHAEL A., GRANTON JOHN, BERGER ROLF M.F., LAUER ANDREA, CHIOSSI ELEONORA, LANDZBERG MICHAEL Bosentan for the treatment of pulmonary arterial hypertension associated with congenital heart defects EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2006 vol. 36 Suppl 3 pp. 25-31 SITBON O., BEGHETTI M., PETIT J., ISERIN L., HUMBERT M., GRESSIN V., SIMONNEAU G. Current treatment options in children with pulmonary arterial hypertension and experiences with oral bosentan EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2006 vol. 36 Suppl 3 pp. 16-24 BEGHETTI MAURICE Fatal coronary artery anomaly presenting as bronchiolitis EUROPEAN JOURNAL OF PEDIATRICS 2006 vol. 165(7) pp. 505- DA CRUZ EDUARDO, AGGOUN YACINE, TISSOT-DAGUETTE CECILE, BEGHETTI MAURICE Coarctation of the aorta: pre and postoperative evaluation with MRI and MR angiography; correlation with echocardiography and surgery INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING 2006 vol. 22 pp. 457-475 DIDIER D, SAINT-MARTIN C, LAPIERRE C, TRINDADE PT, LAHALAIDI N, VALLEE JP, KALANGOS A, FRIEDLI B, BEGHETTI M Operative correction of cor triatriatum sinister with systemic venous return anomaly (inferior vena cava-left atrium) JOURNAL OF CARDIAC SURGERY 2006 vol. 21 pp. 578-579 CIKIRIKCIOGLU M, TATAR T, ANTAL AD, CRUZ EDA, DIDIER D, KALANGOS A Comparison of classifications for heart failure in children undergoing valvular surgery JOURNAL OF PEDIATRICS 2006 vol. 149 pp. 210-215 TISSIERES P, AGGOUN Y, DA CRUZ E, SIERRA J, MENSI N, KALANGOS A, BEGHETTI M Long-term outcome after surgical intervention and interventional procedures for the management of Takayasu's arteritis in children JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 2006 vol. 132 pp. 656-664 KALANGOS A, CHRISTENSON JT, CIKIRIKCIOGLU M, VALA D, BUERGE A, SIMONET F, DIDIER D, BEGHETTI M, JAEGGI E Nitric oxide precursors and congenital cardiac surgery: a randomized controlled trial of oral citrulline. Definition of pulmonary hypertension in Fontan circulation? JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY 2006 vol. 32(6) pp. 1501-1502 BEGHETTI MAURICE, AGGOUN YACINE, DA CRUZ EDUARDO Intravenous adenosine for refractory pulmonary hypertension in a low-weight premature newborn: a potential new drug for rescue therapy PEDIATRIC CRITICAL CARE MEDICINE : A JOURNAL OF THE SOCIETY OF CRITICAL CARE MEDICINE AND THE WORLD FEDERATION OF PEDIATRIC INTENSIVE AND CRITICAL CARE SOCIETIES 2006 vol. 7(4) pp. 380-382 MOTTI ALESSANDRO, TISSOT CECILE, RIMENSBERGER PETER C., PRINA-ROUSSO ALINE, AGGOUN YACINE, BERNER MICHEL, BEGHETTI MAURICE, DA CRUZ EDUARDO The role of endothelin-I in hyperoxia-induced lung injury in mice RESPIRATORY RESEARCH 2006 vol. 7(1) pp. 45-0 HABRE W, PETAK F, RUCHONNET-METRAILLER I, DONATI Y, TOLSA JF, LELE E, ALBU G, BEGHETTI M, BARAZZONE-ARGIROFFO C Hypertension artérielle pulmonaire des cardiopathies congénitales REVUE DES MALADIES RESPIRATOIRES 2006 vol. 23(4 Suppl) pp. 49-59 BEGHETTI MAURICE Evolution après dérivation cavo-pulmonaire partielle : l'expérience genevoise de 1985 à 2000 ARCHIVES DES MALADIES DU COEUR ET DES VAISSEAUX 2003 vol. 96 pp. 92-99 STAUFFER ETTLIN M, FAIDUTTI B, FRIEDLI B Effects of inhaled nitric oxide and intravenous magnesium sulphate, alone and in combination, in a porcine model of hypoxic pulmonary hypertension MEDICAL SCIENCE MONITOR : INTERNATIONAL MEDICAL JOURNAL OF EXPERIMENTAL AND CLINICAL RESEARCH 2003 vol. 9 pp. 193-198 BEGHETTI MAURICE, SPAHR-SCHOPFER ISABELLE, MENSI NOURY, MOREL DENIS, RIMENSBERGER PETER How to diminish reoperation rates after initial repair of Tetralogy of Fallot ANNALS OF THORACIC SURGERY 2002 vol. 73 pp. 96-101 FAIDUTTI B, CHRISTENSON JT, BEGHETTI M, FRIEDLI B, KALANGOS A Aerosolized iloprost induces a mild but sustained inhibition of platelet aggregation EUROPEAN RESPIRATORY JOURNAL 2002 vol. 19 pp. 518-524 BEGHETTI M, REBER G, DE MOERLOOSE P, VADAS L, CHIAPPE A, SPAHR-SCHOPFER I, RIMENSBERGER PC Images in cardiology. Thoraco-omphalagus twins : heart to heart HEART 2002 vol. 87 pp. 278- BEGHETTI M, ABDEL-MASSIH T, BONHOEFFER P Domaines de recherche |