Bienvenue dans la base de données-recherche

Pathogenèse et le traitement des allergies alimentaires

La thématique du groupe est la recherche sur la pathogenèse et le traitement des allergies alimentaires. Notre projet principal bénéficie d'une subvention de recherche du FNRS et concerne le rôle des lymphocytes T du tractus digestif dans l'allergie alimentaire. Nous utilisons un modèle de souris présentant une anaphylaxie alimentaire comparable à l'allergie alimentaire chez l'humain. Nous comparons divers paramètres immunologiques (production de cytokines, d'anticorpsż) qui nous permettent de déterminer le rôle des divers sites immunitaires associés au tractus digestif, en fonction du status clinique. En utilisant ce modèle, nous avons découvert que les lymphocytes T des plaques de Peyer, plus particulièrement par la sécrétion de l'interleukin 10, permettent de moduler la réponse allergique en instaurant une tolérance.
Aucun traitement actif de l'allergie alimentaire n'est disponible actuellement. En appliquant nos découvertes sur la pathogenèse de la maladie, nous utilisons des agents infectieux permettant par la production de cytokines tels l'IL-10 de moduler la réponse immunitaire spécifique à des antigènes alimentaires majeurs. D'autres substances immunomodulatrices sont également testées en collaboration avec des partenaires de l'industrie.

Publications du groupe

Snack seeds allergy in children.
ALLERGY
2010 vol. 65(1) pp. 136-137
CAUBET JC, HOFER M, EIGENMANN P, WASSENBERG J

State of the art and new horizons in the diagnosis and management of egg allergy.
ALLERGY
2010 vol. 65(3) pp. 283-289
BENHAMOU AH, CAUBET JC, EIGENMANN PA, NOWAK A, MARCOS CP, RECHE M, URISU A

Allergic triggers in atopic dermatitis.
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
2010 vol. 30(3) pp. 289-307
CAUBET JC, EIGENMANN P

Intestinal lamina propria TcRgammadelta+ lymphocytes selectively express IL-10 and IL-17.
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY : OFFICIAL ORGAN OF THE INTERNATIONAL ASSOCIATION OF ASTHMOLOGY (INTERASMA) AND SOCIEDAD LATINOAMERICANA DE ALERGIA E INMUNOLOGIA
2010 vol. 20(5) pp. 391-401
ASIGBETSE KE, EIGENMANN P, FROSSARD CP

Built environment, parents' perception, and children's vigorous outdoor play.
PREVENTIVE MEDICINE
2010 vol. 50(5-6) pp. 251-256
BRINGOLF-ISLER B. AND AL.

New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses.
EMERGING INFECTIOUS DISEASES (PRINT)
2009 vol. 15(5) pp. 719-726
TAPPAREL C AND AL.

Sublingual immunotherapy is not always a safe alternative to subcutaneous immunotherapy.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2009 vol. 124(2) pp. 378-379
COCHARD MM, EIGENMANN P

Mechanisms of food allergy
PEDIATRIC ALLERGY AND IMMUNOLOGY
2009 vol. 20(1) pp. 5-11
EIGENMANN P

The ImmunoCAP (R) Rapid Wheeze/Rhinitis Child test is useful in the initial allergy diagnosis of children with respiratory symptoms
PEDIATRIC ALLERGY AND IMMUNOLOGY
2009 vol. 20(8) pp. 772-779
EIGENMANN P, KUENZLI M, D'APUZZO V, KEHRT R, JOERG W, REINHARDT M, RUDENGREN M, BORRES MP, LAUENER RP

Component-resolved diagnosis in food allergy, are micro-array assays helpful to the clinician?
ALLERGY
2008 vol. 63(11) pp. 1519-1520
EIGENMANN P

Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report.
ALLERGY
2008 vol. 63(1) pp. 5-34
BACHARIER LB AND AL.

Late side-effects during systemic immunotherapy in children.
ALLERGY
2008 vol. ;63(11) pp. 1561-1562
CAUBET JC, EIGENMANN P

Avirulant Salmonella typhimurium strains prevent food allergy in mice.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
2008 vol. 151(3) pp. 546-553
EIGENMANN P, ASIGBETSE KE, FROSSARD CP

The role of IL-10 in preventing food-induced anaphylaxis.
EXPERT OPINION ON BIOLOGICAL THERAPY
2008 vol. ;8(9) pp. 1309-1317
FROSSARD CHRISTOPHE, EIGENMANN P

Early identification of atopy in the prediction of persistent asthma in children.
LANCET
2008 vol. 372(9643) pp. 1100-1106
SLY PD AND AL.

iPAC: an initiative to fight the burden of allergies in children.
PEDIATRIC ALLERGY AND IMMUNOLOGY
2008 vol. 19 pp. 1-3
EIGENMANN P, MURARO A, SAMPSON HA, WAHN U

Correlation between specific immunoglobulin E levels and the severity of reactions in egg allergic patients.
PEDIATRIC ALLERGY AND IMMUNOLOGY : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF PEDIATRIC ALLERGY AND IMMUNOLOGY
2008 vol. 19(2) pp. 173-179
BENHAMOU AH, ZAMORA SA, EIGENMANN P

Dietary prevention of allergic diseases in infants and small children.
PEDIATRIC ALLERGY AND IMMUNOLOGY : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF PEDIATRIC ALLERGY AND IMMUNOLOGY
2008 vol. 19(1) pp. 1-4
HOST A AND AL.

New visions for food allergy: an iPAC summary and future trends.
PEDIATRIC ALLERGY AND IMMUNOLOGY : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF PEDIATRIC ALLERGY AND IMMUNOLOGY
2008 vol. 19 pp. 26-39
EIGENMANN P, BEYER K, BURKS AW, LACK G, LIACOURAS CA, HOURIHANE JO'B, SODERGREN E

Antihistamine and sodium cromoglycate medication for food cold water exercise-induced anaphylaxis
ALLERGY
2007 vol. 62 pp. 1471-1472
BENHAMOU AH, VANINI G, LANTIN JP, EIGENMANN PA

Eczematous reactions to food in atopic eczema: position paper of the EAACI and GA(2)LEN
ALLERGY
2007 vol. 62 pp. 723-728
WERFEL T, BALLMER-WEBER B, EIGENMANN PA, NIGGEMANN B, RANCE F, TURJANMAA K, WORM M

The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology.
ALLERGY
2007 vol. 62(8) pp. 857-871
MURARO A, ROBERTS G, CLARK A, EIGENMANN PA, HALKEN S, LACK G, MONERET-VAUTRIN A, NIGGEMANN B, RANCÉ F

Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
2007 vol. 119 pp. 952-959
FROSSARD CP, STEIDLER L, EIGENMANN PA

Food colourings, preservatives, and hyperactivity.
LANCET
2007 vol. 370(9598) pp. 1524-1525
EIGENMANN PA, HAENGGELI CA

The spectrum of cow's milk allergy
PEDIATRIC ALLERGY AND IMMUNOLOGY
2007 vol. 18 pp. 265-271
EIGENMANN P

The spectrum of cow's milk allergy.
PEDIATRIC ALLERGY AND IMMUNOLOGY : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF PEDIATRIC ALLERGY AND IMMUNOLOGY
2007 vol. 18(3) pp. 265-271
EIGENMANN PA

Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Repor t
ALLERGY
2006 vol. 61(8) pp. 969-987
AKDIS CA ET AL.

Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Repor t.
ALLERGY
2006 vol. 61(8) pp. 969-987
AKDIS C.A. ET AL.

Trends in prevalence of asthma, allergic rhinitis and atopic dermatitis in 5-7-year old Swiss children from 1992 to 2001
ALLERGY
2006 vol. 61(5) pp. 556-562
GRIZE L. ET AL.

Continuing food-avoidance diets after negative food challenges
PEDIATRIC ALLERGY AND IMMUNOLOGY
2006 vol. 17 pp. 601-605
EIGENMANN PA, CAUBET JC, ZAMORA SA

T lymphocytes in food allergy : overview of an intricate network of circulating and organ-resident cells
PEDIATRIC ALLERGY AND IMMUNOLOGY : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF PEDIATRIC ALLERGY AND IMMUNOLOGY
2002 vol. 13 pp. 162-171
EIGENMANN PA

Oral carrageenan induces antigen-dependent oral tolerance : prevention of anaphylaxis and induction of lymphocyte anergy in a murine model of food allergy
PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION
2001 vol. 49 pp. 417-422
FROSSARD CP, HAUSER C, EIGENMANN PA

Allergenicity of major cow's milk and peanut proteins determined by IgE and IgG immunoblotting
ALLERGY
2000 vol. 55 pp. 43-49
SZABO ISABELLE, EIGENMANN PHILIPPE

The mucosal adhesion receptor alpha 4 beta 7 integrin is selectively increased in lymphocytes stimulated with beta-lactoblobulin in children allergic to cow's milk
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
1999 vol. 103 pp. 931-936
EIGENMANN PA, TROPIA L, HAUSER C

Domaines de recherche

MODELE MURIN
ALLERGIES ALIMENTAIRES




BASE DE DONNÉES-RECHERCHE	GROUPE DE RECHERCHE CLINIQUE ORIENTEE PATIENTS

Philippe EIGENMANN	CV du Chef de Groupe	Sujet de Recherche	Composition du Groupe


	Coordonnées du groupe Dr Ch. FROSSARD HUG/ Dpt Pédiatrie Bât. A Rue Gabrielle-Perret-Gentil 4 1211 Genève 14 Suisse Christophe.Frossard@unige.ch Tél.: 022/372.93.86 Fax: 022/372.93.69 Commentaires Pages générées le 17.11.2015		Sujet de recherche \| Publications du groupe \| Domaines de recherche Pathogenèse et le traitement des allergies alimentaires La thématique du groupe est la recherche sur la pathogenèse et le traitement des allergies alimentaires. Notre projet principal bénéficie d'une subvention de recherche du FNRS et concerne le rôle des lymphocytes T du tractus digestif dans l'allergie alimentaire. Nous utilisons un modèle de souris présentant une anaphylaxie alimentaire comparable à l'allergie alimentaire chez l'humain. Nous comparons divers paramètres immunologiques (production de cytokines, d'anticorpsż) qui nous permettent de déterminer le rôle des divers sites immunitaires associés au tractus digestif, en fonction du status clinique. En utilisant ce modèle, nous avons découvert que les lymphocytes T des plaques de Peyer, plus particulièrement par la sécrétion de l'interleukin 10, permettent de moduler la réponse allergique en instaurant une tolérance. Aucun traitement actif de l'allergie alimentaire n'est disponible actuellement. En appliquant nos découvertes sur la pathogenèse de la maladie, nous utilisons des agents infectieux permettant par la production de cytokines tels l'IL-10 de moduler la réponse immunitaire spécifique à des antigènes alimentaires majeurs. D'autres substances immunomodulatrices sont également testées en collaboration avec des partenaires de l'industrie. Publications du groupe Snack seeds allergy in children. ALLERGY 2010 vol. 65(1) pp. 136-137 CAUBET JC, HOFER M, EIGENMANN P, WASSENBERG J State of the art and new horizons in the diagnosis and management of egg allergy. ALLERGY 2010 vol. 65(3) pp. 283-289 BENHAMOU AH, CAUBET JC, EIGENMANN PA, NOWAK A, MARCOS CP, RECHE M, URISU A Allergic triggers in atopic dermatitis. IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA 2010 vol. 30(3) pp. 289-307 CAUBET JC, EIGENMANN P Intestinal lamina propria TcRgammadelta+ lymphocytes selectively express IL-10 and IL-17. JOURNAL OF INVESTIGATIONAL ALLERGOLOGY & CLINICAL IMMUNOLOGY : OFFICIAL ORGAN OF THE INTERNATIONAL ASSOCIATION OF ASTHMOLOGY (INTERASMA) AND SOCIEDAD LATINOAMERICANA DE ALERGIA E INMUNOLOGIA 2010 vol. 20(5) pp. 391-401 ASIGBETSE KE, EIGENMANN P, FROSSARD CP Built environment, parents' perception, and children's vigorous outdoor play. PREVENTIVE MEDICINE 2010 vol. 50(5-6) pp. 251-256 BRINGOLF-ISLER B. AND AL. New respiratory enterovirus and recombinant rhinoviruses among circulating picornaviruses. EMERGING INFECTIOUS DISEASES (PRINT) 2009 vol. 15(5) pp. 719-726 TAPPAREL C AND AL. Sublingual immunotherapy is not always a safe alternative to subcutaneous immunotherapy. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2009 vol. 124(2) pp. 378-379 COCHARD MM, EIGENMANN P Mechanisms of food allergy PEDIATRIC ALLERGY AND IMMUNOLOGY 2009 vol. 20(1) pp. 5-11 EIGENMANN P The ImmunoCAP (R) Rapid Wheeze/Rhinitis Child test is useful in the initial allergy diagnosis of children with respiratory symptoms PEDIATRIC ALLERGY AND IMMUNOLOGY 2009 vol. 20(8) pp. 772-779 EIGENMANN P, KUENZLI M, D'APUZZO V, KEHRT R, JOERG W, REINHARDT M, RUDENGREN M, BORRES MP, LAUENER RP Component-resolved diagnosis in food allergy, are micro-array assays helpful to the clinician? ALLERGY 2008 vol. 63(11) pp. 1519-1520 EIGENMANN P Diagnosis and treatment of asthma in childhood: a PRACTALL consensus report. ALLERGY 2008 vol. 63(1) pp. 5-34 BACHARIER LB AND AL. Late side-effects during systemic immunotherapy in children. ALLERGY 2008 vol. ;63(11) pp. 1561-1562 CAUBET JC, EIGENMANN P Avirulant Salmonella typhimurium strains prevent food allergy in mice. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 2008 vol. 151(3) pp. 546-553 EIGENMANN P, ASIGBETSE KE, FROSSARD CP The role of IL-10 in preventing food-induced anaphylaxis. EXPERT OPINION ON BIOLOGICAL THERAPY 2008 vol. ;8(9) pp. 1309-1317 FROSSARD CHRISTOPHE, EIGENMANN P Early identification of atopy in the prediction of persistent asthma in children. LANCET 2008 vol. 372(9643) pp. 1100-1106 SLY PD AND AL. iPAC: an initiative to fight the burden of allergies in children. PEDIATRIC ALLERGY AND IMMUNOLOGY 2008 vol. 19 pp. 1-3 EIGENMANN P, MURARO A, SAMPSON HA, WAHN U Correlation between specific immunoglobulin E levels and the severity of reactions in egg allergic patients. PEDIATRIC ALLERGY AND IMMUNOLOGY : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF PEDIATRIC ALLERGY AND IMMUNOLOGY 2008 vol. 19(2) pp. 173-179 BENHAMOU AH, ZAMORA SA, EIGENMANN P Dietary prevention of allergic diseases in infants and small children. PEDIATRIC ALLERGY AND IMMUNOLOGY : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF PEDIATRIC ALLERGY AND IMMUNOLOGY 2008 vol. 19(1) pp. 1-4 HOST A AND AL. New visions for food allergy: an iPAC summary and future trends. PEDIATRIC ALLERGY AND IMMUNOLOGY : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF PEDIATRIC ALLERGY AND IMMUNOLOGY 2008 vol. 19 pp. 26-39 EIGENMANN P, BEYER K, BURKS AW, LACK G, LIACOURAS CA, HOURIHANE JO'B, SODERGREN E Antihistamine and sodium cromoglycate medication for food cold water exercise-induced anaphylaxis ALLERGY 2007 vol. 62 pp. 1471-1472 BENHAMOU AH, VANINI G, LANTIN JP, EIGENMANN PA Eczematous reactions to food in atopic eczema: position paper of the EAACI and GA(2)LEN ALLERGY 2007 vol. 62 pp. 723-728 WERFEL T, BALLMER-WEBER B, EIGENMANN PA, NIGGEMANN B, RANCE F, TURJANMAA K, WORM M The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology. ALLERGY 2007 vol. 62(8) pp. 857-871 MURARO A, ROBERTS G, CLARK A, EIGENMANN PA, HALKEN S, LACK G, MONERET-VAUTRIN A, NIGGEMANN B, RANCÉ F Oral administration of an IL-10-secreting Lactococcus lactis strain prevents food-induced IgE sensitization JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2007 vol. 119 pp. 952-959 FROSSARD CP, STEIDLER L, EIGENMANN PA Food colourings, preservatives, and hyperactivity. LANCET 2007 vol. 370(9598) pp. 1524-1525 EIGENMANN PA, HAENGGELI CA The spectrum of cow's milk allergy PEDIATRIC ALLERGY AND IMMUNOLOGY 2007 vol. 18 pp. 265-271 EIGENMANN P The spectrum of cow's milk allergy. PEDIATRIC ALLERGY AND IMMUNOLOGY : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF PEDIATRIC ALLERGY AND IMMUNOLOGY 2007 vol. 18(3) pp. 265-271 EIGENMANN PA Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Repor t ALLERGY 2006 vol. 61(8) pp. 969-987 AKDIS CA ET AL. Diagnosis and treatment of atopic dermatitis in children and adults: European Academy of Allergology and Clinical Immunology/American Academy of Allergy, Asthma and Immunology/PRACTALL Consensus Repor t. ALLERGY 2006 vol. 61(8) pp. 969-987 AKDIS C.A. ET AL. Trends in prevalence of asthma, allergic rhinitis and atopic dermatitis in 5-7-year old Swiss children from 1992 to 2001 ALLERGY 2006 vol. 61(5) pp. 556-562 GRIZE L. ET AL. Continuing food-avoidance diets after negative food challenges PEDIATRIC ALLERGY AND IMMUNOLOGY 2006 vol. 17 pp. 601-605 EIGENMANN PA, CAUBET JC, ZAMORA SA T lymphocytes in food allergy : overview of an intricate network of circulating and organ-resident cells PEDIATRIC ALLERGY AND IMMUNOLOGY : OFFICIAL PUBLICATION OF THE EUROPEAN SOCIETY OF PEDIATRIC ALLERGY AND IMMUNOLOGY 2002 vol. 13 pp. 162-171 EIGENMANN PA Oral carrageenan induces antigen-dependent oral tolerance : prevention of anaphylaxis and induction of lymphocyte anergy in a murine model of food allergy PEDIATRIC RESEARCH : AN INTERNATIONAL JOURNAL OF CLINICAL, LABORATORY AND DEVELOPMENTAL INVESTIGATION 2001 vol. 49 pp. 417-422 FROSSARD CP, HAUSER C, EIGENMANN PA Allergenicity of major cow's milk and peanut proteins determined by IgE and IgG immunoblotting ALLERGY 2000 vol. 55 pp. 43-49 SZABO ISABELLE, EIGENMANN PHILIPPE The mucosal adhesion receptor alpha 4 beta 7 integrin is selectively increased in lymphocytes stimulated with beta-lactoblobulin in children allergic to cow's milk JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 1999 vol. 103 pp. 931-936 EIGENMANN PA, TROPIA L, HAUSER C Domaines de recherche MODELE MURIN ALLERGIES ALIMENTAIRES